Long-term clinical outcome of paraneoplastic cerebellar degeneration and anti-Yo antibodies

The outcome of 34 women with anti-Yo-associated paraneoplastic cerebellar degeneration was reviewed. Three patients had not developed cancer after more than 4 years of follow-up. The only independent predictor for survival was the type of associated tumor (risk ratio, 1.79; 95% CI, 1.02 to 3.12). Me...

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Detalles Bibliográficos
Autores: Rojas-Marcos, Iñigo, Graus Ribas, Francesc, Keine-Guibert, Florence, Reñé Ramírez, Ramon, Delattre, Jean Yves, Ramon Torrell, Josep M. (Josep Maria), Dalmau Obrador, Josep, Posner, Jerome B.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2000
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/178218
Acceso en línea:https://hdl.handle.net/2445/178218
Access Level:acceso abierto
Palabra clave:Fisiologia
Patologia
Cerebel
Degeneració (Patologia)
Physiology
Pathology
Cerebellum
Degeneration (Pathology)
Descripción
Sumario:The outcome of 34 women with anti-Yo-associated paraneoplastic cerebellar degeneration was reviewed. Three patients had not developed cancer after more than 4 years of follow-up. The only independent predictor for survival was the type of associated tumor (risk ratio, 1.79; 95% CI, 1.02 to 3.12). Median survival was 100 months for patients with breast cancer and 22 for those with gynecologic cancer. Although paraneoplastic cerebellar degeneration leads to the diagnosis of cancer in 63% of the patients, cancer progression was the cause of death in 52%.