Importance of a deficiency in S-adenosyl-L-methionine synthesis in the pathogenesis of liver injury
One of the features of liver cirrhosis is an abnormal metabolism of methionine--a characteristic that was described more than a half a century ago. Thus, after an oral load of methionine, the rate of clearance of this amino acid from the blood is markedly impaired in cirrhotic patients compared with...
| Autores: | , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2002 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/21479 |
| Acceso en línea: | https://hdl.handle.net/10171/21479 |
| Access Level: | acceso abierto |
| Palabra clave: | Methionine S-adenosyl-l-methionine SAMe Methionine adenosyltransferase Liver injury Liver regeneration Cirrhosis Oxidative stress Protein S-nitrosylation |
| id |
ES_39e63bc52c2e6714385fbbcdf4fd7aaa |
|---|---|
| oai_identifier_str |
oai:dadun.unav.edu:10171/21479 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
Importance of a deficiency in S-adenosyl-L-methionine synthesis in the pathogenesis of liver injuryMartinez-Chantar, M.L. (María Luz)|||/items/df06120b-2a53-4074-a155-638f899b2ce5Ruiz Garcia-Trevijano, E. (Elena)|||/items/bc37b3f6-83de-42b9-bb68-e90d1296c35cLatasa, M.U. (María Ujué)|||/items/e1e74596-1598-4722-a96a-7bdd7cdec356Perez-Mato, I. (Isabel)|||/items/1bd17cf0-14ff-44d1-9cf5-4ec7e08251d8Sanchez-del-Pino, M.M. (Manuel M.)|||/items/ebbc885a-5036-4bc0-b697-16ada2926964Corrales, F.J. (Fernando José)|||/items/96b34843-1185-4837-be4b-d1d63e688ec2Avila, M.A. (Matías Antonio)|||/items/3ad9abbb-c18d-445b-86cf-cb76be15419fMato, J.M. (José María)|||/items/302dc624-b0d3-4703-90cf-1a97690ebc79MethionineS-adenosyl-l-methionineSAMeMethionine adenosyltransferaseLiver injuryLiver regenerationCirrhosisOxidative stressProtein S-nitrosylationOne of the features of liver cirrhosis is an abnormal metabolism of methionine--a characteristic that was described more than a half a century ago. Thus, after an oral load of methionine, the rate of clearance of this amino acid from the blood is markedly impaired in cirrhotic patients compared with that in control subjects. Almost 15 y ago we observed that the failure to metabolize methionine in cirrhosis was due to an abnormally low activity of the enzyme methionine adenosyltransferase (EC 2.5.1.6). This enzyme converts methionine, in the presence of ATP, to S-adenosyl-L-methionine (SAMe), the main biological methyl donor. Since then, it has been suspected that a deficiency in hepatic SAMe may contribute to the pathogenesis of the liver in cirrhosis. The studies reviewed here are consistent with this hypothesis.American Society for NutritionDadun. Depósito Académico Digital Universidad de Navarra20122012-04-0220022002-01-0120022002-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/21479reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/214792026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Importance of a deficiency in S-adenosyl-L-methionine synthesis in the pathogenesis of liver injury |
| title |
Importance of a deficiency in S-adenosyl-L-methionine synthesis in the pathogenesis of liver injury |
| spellingShingle |
Importance of a deficiency in S-adenosyl-L-methionine synthesis in the pathogenesis of liver injury Martinez-Chantar, M.L. (María Luz)|||/items/df06120b-2a53-4074-a155-638f899b2ce5 Methionine S-adenosyl-l-methionine SAMe Methionine adenosyltransferase Liver injury Liver regeneration Cirrhosis Oxidative stress Protein S-nitrosylation |
| title_short |
Importance of a deficiency in S-adenosyl-L-methionine synthesis in the pathogenesis of liver injury |
| title_full |
Importance of a deficiency in S-adenosyl-L-methionine synthesis in the pathogenesis of liver injury |
| title_fullStr |
Importance of a deficiency in S-adenosyl-L-methionine synthesis in the pathogenesis of liver injury |
| title_full_unstemmed |
Importance of a deficiency in S-adenosyl-L-methionine synthesis in the pathogenesis of liver injury |
| title_sort |
Importance of a deficiency in S-adenosyl-L-methionine synthesis in the pathogenesis of liver injury |
| dc.creator.none.fl_str_mv |
Martinez-Chantar, M.L. (María Luz)|||/items/df06120b-2a53-4074-a155-638f899b2ce5 Ruiz Garcia-Trevijano, E. (Elena)|||/items/bc37b3f6-83de-42b9-bb68-e90d1296c35c Latasa, M.U. (María Ujué)|||/items/e1e74596-1598-4722-a96a-7bdd7cdec356 Perez-Mato, I. (Isabel)|||/items/1bd17cf0-14ff-44d1-9cf5-4ec7e08251d8 Sanchez-del-Pino, M.M. (Manuel M.)|||/items/ebbc885a-5036-4bc0-b697-16ada2926964 Corrales, F.J. (Fernando José)|||/items/96b34843-1185-4837-be4b-d1d63e688ec2 Avila, M.A. (Matías Antonio)|||/items/3ad9abbb-c18d-445b-86cf-cb76be15419f Mato, J.M. (José María)|||/items/302dc624-b0d3-4703-90cf-1a97690ebc79 |
| author |
Martinez-Chantar, M.L. (María Luz)|||/items/df06120b-2a53-4074-a155-638f899b2ce5 |
| author_facet |
Martinez-Chantar, M.L. (María Luz)|||/items/df06120b-2a53-4074-a155-638f899b2ce5 Ruiz Garcia-Trevijano, E. (Elena)|||/items/bc37b3f6-83de-42b9-bb68-e90d1296c35c Latasa, M.U. (María Ujué)|||/items/e1e74596-1598-4722-a96a-7bdd7cdec356 Perez-Mato, I. (Isabel)|||/items/1bd17cf0-14ff-44d1-9cf5-4ec7e08251d8 Sanchez-del-Pino, M.M. (Manuel M.)|||/items/ebbc885a-5036-4bc0-b697-16ada2926964 Corrales, F.J. (Fernando José)|||/items/96b34843-1185-4837-be4b-d1d63e688ec2 Avila, M.A. (Matías Antonio)|||/items/3ad9abbb-c18d-445b-86cf-cb76be15419f Mato, J.M. (José María)|||/items/302dc624-b0d3-4703-90cf-1a97690ebc79 |
| author_role |
author |
| author2 |
Ruiz Garcia-Trevijano, E. (Elena)|||/items/bc37b3f6-83de-42b9-bb68-e90d1296c35c Latasa, M.U. (María Ujué)|||/items/e1e74596-1598-4722-a96a-7bdd7cdec356 Perez-Mato, I. (Isabel)|||/items/1bd17cf0-14ff-44d1-9cf5-4ec7e08251d8 Sanchez-del-Pino, M.M. (Manuel M.)|||/items/ebbc885a-5036-4bc0-b697-16ada2926964 Corrales, F.J. (Fernando José)|||/items/96b34843-1185-4837-be4b-d1d63e688ec2 Avila, M.A. (Matías Antonio)|||/items/3ad9abbb-c18d-445b-86cf-cb76be15419f Mato, J.M. (José María)|||/items/302dc624-b0d3-4703-90cf-1a97690ebc79 |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Methionine S-adenosyl-l-methionine SAMe Methionine adenosyltransferase Liver injury Liver regeneration Cirrhosis Oxidative stress Protein S-nitrosylation |
| topic |
Methionine S-adenosyl-l-methionine SAMe Methionine adenosyltransferase Liver injury Liver regeneration Cirrhosis Oxidative stress Protein S-nitrosylation |
| description |
One of the features of liver cirrhosis is an abnormal metabolism of methionine--a characteristic that was described more than a half a century ago. Thus, after an oral load of methionine, the rate of clearance of this amino acid from the blood is markedly impaired in cirrhotic patients compared with that in control subjects. Almost 15 y ago we observed that the failure to metabolize methionine in cirrhosis was due to an abnormally low activity of the enzyme methionine adenosyltransferase (EC 2.5.1.6). This enzyme converts methionine, in the presence of ATP, to S-adenosyl-L-methionine (SAMe), the main biological methyl donor. Since then, it has been suspected that a deficiency in hepatic SAMe may contribute to the pathogenesis of the liver in cirrhosis. The studies reviewed here are consistent with this hypothesis. |
| publishDate |
2002 |
| dc.date.none.fl_str_mv |
2002 2002-01-01 2002 2002-01-01 2012 2012-04-02 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/21479 |
| url |
https://hdl.handle.net/10171/21479 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
American Society for Nutrition |
| publisher.none.fl_str_mv |
American Society for Nutrition |
| dc.source.none.fl_str_mv |
reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
| instname_str |
Universidad de Navarra |
| reponame_str |
Dadun. Depósito Académico Digital de la Universidad de Navarra |
| collection |
Dadun. Depósito Académico Digital de la Universidad de Navarra |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869406200260460544 |
| score |
15.300719 |