Ag-presenting CpG-activated pDCs prime Th17 cells that induce tumor regression

Guéry, L. (Leslie)|||/items/0eb28b69-6340-4de0-91f8-3e32e8fbf810; Dubrot-Armendáriz, J. (Juan)|||/items/b42afe78-7095-4682-8c2c-0904580d8d53; Lippens, C. (Carla)|||/items/f617161c-2862-4140-bf35-1405955cc044; Brighouse, D. (Dale)|||/items/b526e470-5918-4ec1-9ef6-cc47fb647515; Malinge, P. (Pauline)|||/items/28e5d332-fbbb-47e9-a532-093d990d3da7; Irla, M. (Magali)|||/items/a7654a7e-fd1c-42d5-a55d-31f76a63957f; Pot, C. (Caroline)|||/items/c727e7e1-19dc-41d7-be5d-ee51d4127059; Reith, W. (Walter)|||/items/ddc6cd9b-c893-4e92-ac21-46e826cefea7; Waldburger, J.M. (Jean-Marc)|||/items/edea8c66-e9a7-4b2a-8c39-8a6d3bd2fcdc; Hugues, S. (Stéphanie)|||/items/437178cd-54c9-41db-b5c9-fa25dea04152

Ag-presenting CpG-activated pDCs prime Th17 cells that induce tumor regression

Plasmacytoid dendritic cells (pDC) rapidly and massively produce type I IFN and other inflammatory cytokines in response to foreign nucleic acids, thereby indirectly influencing T-cell responses. Moreover, antigen (Ag)-presenting pDCs directly regulate T-cell differentiation. Depending on the immune...

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Detalles Bibliográficos
Autores:	Guéry, L. (Leslie)\|\|\|/items/0eb28b69-6340-4de0-91f8-3e32e8fbf810, Dubrot-Armendáriz, J. (Juan)\|\|\|/items/b42afe78-7095-4682-8c2c-0904580d8d53, Lippens, C. (Carla)\|\|\|/items/f617161c-2862-4140-bf35-1405955cc044, Brighouse, D. (Dale)\|\|\|/items/b526e470-5918-4ec1-9ef6-cc47fb647515, Malinge, P. (Pauline)\|\|\|/items/28e5d332-fbbb-47e9-a532-093d990d3da7, Irla, M. (Magali)\|\|\|/items/a7654a7e-fd1c-42d5-a55d-31f76a63957f, Pot, C. (Caroline)\|\|\|/items/c727e7e1-19dc-41d7-be5d-ee51d4127059, Reith, W. (Walter)\|\|\|/items/ddc6cd9b-c893-4e92-ac21-46e826cefea7, Waldburger, J.M. (Jean-Marc)\|\|\|/items/edea8c66-e9a7-4b2a-8c39-8a6d3bd2fcdc, Hugues, S. (Stéphanie)\|\|\|/items/437178cd-54c9-41db-b5c9-fa25dea04152
Tipo de recurso:	artículo
Fecha de publicación:	2014
País:	España
Institución:	Universidad de Navarra
Repositorio:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:	inglés
OAI Identifier:	oai:dadun.unav.edu:10171/122980
Acceso en línea:	https://hdl.handle.net/10171/122980
Access Level:	acceso abierto
Palabra clave:	Plasmacytoid dendritic cells Interferon type I Antigen presentation Major histocompatibility complex class II T helper 17 cells Tumor-infiltrating lymphocytes Cytotoxic T lymphocytes CpG oligodeoxynucleotides Antitumor immunity

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spelling	Ag-presenting CpG-activated pDCs prime Th17 cells that induce tumor regressionGuéry, L. (Leslie)\|\|\|/items/0eb28b69-6340-4de0-91f8-3e32e8fbf810Dubrot-Armendáriz, J. (Juan)\|\|\|/items/b42afe78-7095-4682-8c2c-0904580d8d53Lippens, C. (Carla)\|\|\|/items/f617161c-2862-4140-bf35-1405955cc044Brighouse, D. (Dale)\|\|\|/items/b526e470-5918-4ec1-9ef6-cc47fb647515Malinge, P. (Pauline)\|\|\|/items/28e5d332-fbbb-47e9-a532-093d990d3da7Irla, M. (Magali)\|\|\|/items/a7654a7e-fd1c-42d5-a55d-31f76a63957fPot, C. (Caroline)\|\|\|/items/c727e7e1-19dc-41d7-be5d-ee51d4127059Reith, W. (Walter)\|\|\|/items/ddc6cd9b-c893-4e92-ac21-46e826cefea7Waldburger, J.M. (Jean-Marc)\|\|\|/items/edea8c66-e9a7-4b2a-8c39-8a6d3bd2fcdcHugues, S. (Stéphanie)\|\|\|/items/437178cd-54c9-41db-b5c9-fa25dea04152Plasmacytoid dendritic cellsInterferon type IAntigen presentationMajor histocompatibility complex class IIT helper 17 cellsTumor-infiltrating lymphocytesCytotoxic T lymphocytesCpG oligodeoxynucleotidesAntitumor immunityPlasmacytoid dendritic cells (pDC) rapidly and massively produce type I IFN and other inflammatory cytokines in response to foreign nucleic acids, thereby indirectly influencing T-cell responses. Moreover, antigen (Ag)-presenting pDCs directly regulate T-cell differentiation. Depending on the immune environment, pDCs exhibit either tolerogenic or immunogenic properties. Here, we show that CpG-activated pDCs promote efficient Th17 differentiation. Indeed, Th17 responses are defective in mice selectively lacking MHCII on pDCs upon antigenic challenge. Importantly, in those mice, the frequency of Th17 cells infiltrating solid tumors is impaired. As a result, the recruitment of infiltrating leukocytes in tumors, including tumor-specific cytotoxic T lymphocytes (CTL), is altered and results in increased tumor growth. Importantly, following immunization with tumor Ag and CpG-B, MHCII-restricted Ag presentation by pDCs promotes the differentiation of antitumor Th17 cells that induce intratumor CTL recruitment and subsequent regression of established tumors. Our results highlight a new role for Ag presenting activated pDCs in promoting the development of Th17 cells and impacting on antitumor immunity.American Association for Cancer ResearchDadun. Depósito Académico Digital Universidad de Navarra20142014-01-0120142014-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/122980reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/1229802026-06-21T12:47:57Z
dc.title.none.fl_str_mv	Ag-presenting CpG-activated pDCs prime Th17 cells that induce tumor regression
title	Ag-presenting CpG-activated pDCs prime Th17 cells that induce tumor regression
spellingShingle	Ag-presenting CpG-activated pDCs prime Th17 cells that induce tumor regression Guéry, L. (Leslie)\|\|\|/items/0eb28b69-6340-4de0-91f8-3e32e8fbf810 Plasmacytoid dendritic cells Interferon type I Antigen presentation Major histocompatibility complex class II T helper 17 cells Tumor-infiltrating lymphocytes Cytotoxic T lymphocytes CpG oligodeoxynucleotides Antitumor immunity
title_short	Ag-presenting CpG-activated pDCs prime Th17 cells that induce tumor regression
title_full	Ag-presenting CpG-activated pDCs prime Th17 cells that induce tumor regression
title_fullStr	Ag-presenting CpG-activated pDCs prime Th17 cells that induce tumor regression
title_full_unstemmed	Ag-presenting CpG-activated pDCs prime Th17 cells that induce tumor regression
title_sort	Ag-presenting CpG-activated pDCs prime Th17 cells that induce tumor regression
dc.creator.none.fl_str_mv	Guéry, L. (Leslie)\|\|\|/items/0eb28b69-6340-4de0-91f8-3e32e8fbf810 Dubrot-Armendáriz, J. (Juan)\|\|\|/items/b42afe78-7095-4682-8c2c-0904580d8d53 Lippens, C. (Carla)\|\|\|/items/f617161c-2862-4140-bf35-1405955cc044 Brighouse, D. (Dale)\|\|\|/items/b526e470-5918-4ec1-9ef6-cc47fb647515 Malinge, P. (Pauline)\|\|\|/items/28e5d332-fbbb-47e9-a532-093d990d3da7 Irla, M. (Magali)\|\|\|/items/a7654a7e-fd1c-42d5-a55d-31f76a63957f Pot, C. (Caroline)\|\|\|/items/c727e7e1-19dc-41d7-be5d-ee51d4127059 Reith, W. (Walter)\|\|\|/items/ddc6cd9b-c893-4e92-ac21-46e826cefea7 Waldburger, J.M. (Jean-Marc)\|\|\|/items/edea8c66-e9a7-4b2a-8c39-8a6d3bd2fcdc Hugues, S. (Stéphanie)\|\|\|/items/437178cd-54c9-41db-b5c9-fa25dea04152
author	Guéry, L. (Leslie)\|\|\|/items/0eb28b69-6340-4de0-91f8-3e32e8fbf810
author_facet	Guéry, L. (Leslie)\|\|\|/items/0eb28b69-6340-4de0-91f8-3e32e8fbf810 Dubrot-Armendáriz, J. (Juan)\|\|\|/items/b42afe78-7095-4682-8c2c-0904580d8d53 Lippens, C. (Carla)\|\|\|/items/f617161c-2862-4140-bf35-1405955cc044 Brighouse, D. (Dale)\|\|\|/items/b526e470-5918-4ec1-9ef6-cc47fb647515 Malinge, P. (Pauline)\|\|\|/items/28e5d332-fbbb-47e9-a532-093d990d3da7 Irla, M. (Magali)\|\|\|/items/a7654a7e-fd1c-42d5-a55d-31f76a63957f Pot, C. (Caroline)\|\|\|/items/c727e7e1-19dc-41d7-be5d-ee51d4127059 Reith, W. (Walter)\|\|\|/items/ddc6cd9b-c893-4e92-ac21-46e826cefea7 Waldburger, J.M. (Jean-Marc)\|\|\|/items/edea8c66-e9a7-4b2a-8c39-8a6d3bd2fcdc Hugues, S. (Stéphanie)\|\|\|/items/437178cd-54c9-41db-b5c9-fa25dea04152
author_role	author
author2	Dubrot-Armendáriz, J. (Juan)\|\|\|/items/b42afe78-7095-4682-8c2c-0904580d8d53 Lippens, C. (Carla)\|\|\|/items/f617161c-2862-4140-bf35-1405955cc044 Brighouse, D. (Dale)\|\|\|/items/b526e470-5918-4ec1-9ef6-cc47fb647515 Malinge, P. (Pauline)\|\|\|/items/28e5d332-fbbb-47e9-a532-093d990d3da7 Irla, M. (Magali)\|\|\|/items/a7654a7e-fd1c-42d5-a55d-31f76a63957f Pot, C. (Caroline)\|\|\|/items/c727e7e1-19dc-41d7-be5d-ee51d4127059 Reith, W. (Walter)\|\|\|/items/ddc6cd9b-c893-4e92-ac21-46e826cefea7 Waldburger, J.M. (Jean-Marc)\|\|\|/items/edea8c66-e9a7-4b2a-8c39-8a6d3bd2fcdc Hugues, S. (Stéphanie)\|\|\|/items/437178cd-54c9-41db-b5c9-fa25dea04152
author2_role	author author author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	Plasmacytoid dendritic cells Interferon type I Antigen presentation Major histocompatibility complex class II T helper 17 cells Tumor-infiltrating lymphocytes Cytotoxic T lymphocytes CpG oligodeoxynucleotides Antitumor immunity
topic	Plasmacytoid dendritic cells Interferon type I Antigen presentation Major histocompatibility complex class II T helper 17 cells Tumor-infiltrating lymphocytes Cytotoxic T lymphocytes CpG oligodeoxynucleotides Antitumor immunity
description	Plasmacytoid dendritic cells (pDC) rapidly and massively produce type I IFN and other inflammatory cytokines in response to foreign nucleic acids, thereby indirectly influencing T-cell responses. Moreover, antigen (Ag)-presenting pDCs directly regulate T-cell differentiation. Depending on the immune environment, pDCs exhibit either tolerogenic or immunogenic properties. Here, we show that CpG-activated pDCs promote efficient Th17 differentiation. Indeed, Th17 responses are defective in mice selectively lacking MHCII on pDCs upon antigenic challenge. Importantly, in those mice, the frequency of Th17 cells infiltrating solid tumors is impaired. As a result, the recruitment of infiltrating leukocytes in tumors, including tumor-specific cytotoxic T lymphocytes (CTL), is altered and results in increased tumor growth. Importantly, following immunization with tumor Ag and CpG-B, MHCII-restricted Ag presentation by pDCs promotes the differentiation of antitumor Th17 cells that induce intratumor CTL recruitment and subsequent regression of established tumors. Our results highlight a new role for Ag presenting activated pDCs in promoting the development of Th17 cells and impacting on antitumor immunity.
publishDate	2014
dc.date.none.fl_str_mv	2014 2014-01-01 2014 2014-01-01
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/122980
url	https://hdl.handle.net/10171/122980
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	American Association for Cancer Research
publisher.none.fl_str_mv	American Association for Cancer Research
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra
instname_str	Universidad de Navarra
reponame_str	Dadun. Depósito Académico Digital de la Universidad de Navarra
collection	Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,812429

Ag-presenting CpG-activated pDCs prime Th17 cells that induce tumor regression

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