The altered serum lipidome and its diagnostic potential for Non-Alcoholic Fatty Liver (NAFL)-associated hepatocellular carcinoma

[Background] Non-alcoholic fatty liver disease (NAFLD) is affecting more people globally. Indeed, NAFLD is a spectrum of metabolic dysfunctions that can progress to hepatocellular carcinoma (NAFLD-HCC). This development can occur in a non-cirrhotic liver and thus, often lack clinical surveillance. T...

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Detalles Bibliográficos
Autores: Lewinska, Monika, Santos-Laso, Álvaro, Arretxe, Enara, Alonso, Cristina, Zhuravleva, Ekaterina, Jiménez-Agüero, Raúl, Eizaguirre, Emma, Pareja, María Jesús, Romero-Gómez, Manuel, Arrese, Marco, Suppli, Malte P., Knop, Filip K., Karlsen Oversoe, Stine, Villadsen, Gerda Elisabeth, Decaens, Thomas, Carrilho, Flair Jose, Oliveira, Claudia P., Sangro, Bruno, Macías, Rocío I. R., Banales, Jesús M., Andersen, Jesper B.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/269841
Acceso en línea:http://hdl.handle.net/10261/269841
Access Level:acceso abierto
Palabra clave:NAFLD
HCC
Metabolomics
Lipidomics
Biomarker discovery
Descripción
Sumario:[Background] Non-alcoholic fatty liver disease (NAFLD) is affecting more people globally. Indeed, NAFLD is a spectrum of metabolic dysfunctions that can progress to hepatocellular carcinoma (NAFLD-HCC). This development can occur in a non-cirrhotic liver and thus, often lack clinical surveillance. The aim of this study was to develop non-invasive surveillance method for NAFLD-HCC.

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