Platelet miRNA Biosignature Discriminates between Dementia with Lewy Bodies and Alzheimer’s Disease

Dementia with Lewy bodies (DLB) is one of the most common causes of degenerative dementia, after Alzheimer's disease (AD), and presents pathological and clinical overlap with both AD and Parkinson's disease (PD). Consequently, only one in three DLB cases is diagnosed correctly. Platelets,...

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Autores: Gámez Valero, Ana, Campdelacreu i Fumadó, Jaume, Vilas, Dolores, Ispierto, Lourdes, Gascón-Bayarri, Jordi, Reñé Ramírez, Ramon, Álvarez, Ramiro, Armengol, Maria P., Borràs i Serres, Francesc Enric, Beyer, Katrin
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/180503
Acceso en línea:https://hdl.handle.net/2445/180503
Access Level:acceso abierto
Palabra clave:Micro RNAs
Demència senil
Malaltia d'Alzheimer
Senile dementia
Alzheimer's disease
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spelling Platelet miRNA Biosignature Discriminates between Dementia with Lewy Bodies and Alzheimer’s DiseaseGámez Valero, AnaCampdelacreu i Fumadó, JaumeVilas, DoloresIspierto, LourdesGascón-Bayarri, JordiReñé Ramírez, RamonÁlvarez, RamiroArmengol, Maria P.Borràs i Serres, Francesc EnricBeyer, KatrinMicro RNAsDemència senilMalaltia d'AlzheimerMicro RNAsSenile dementiaAlzheimer's diseaseDementia with Lewy bodies (DLB) is one of the most common causes of degenerative dementia, after Alzheimer's disease (AD), and presents pathological and clinical overlap with both AD and Parkinson's disease (PD). Consequently, only one in three DLB cases is diagnosed correctly. Platelets, previously related to neurodegeneration, contain microRNAs (miRNAs) whose analysis may provide disease biomarkers. Here, we profiled the whole platelet miRNA transcriptome from DLB patients and healthy controls. Differentially expressed miRNAs were further validated in three consecutive studies from 2017 to 2019 enrolling 162 individuals, including DLB, AD, and PD patients, and healthy controls. Results comprised a seven-miRNA biosignature, showing the highest diagnostic potential for the differentiation between DLB and AD. Additionally, compared to controls, two miRNAs were down-regulated in DLB, four miRNAs were up-regulated in AD, and two miRNAs were down-regulated in PD. Predictive target analysis identified three disease-specific clusters of pathways as a result of platelet-miRNA deregulation. Our cross-sectional study assesses the identification of a novel, highly specific and sensitive platelet-associated miRNA-based biosignature, which distinguishes DLB from AD.MDPI AG2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/180503Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/biomedicines9091272Biomedicines, 2021, vol. 9, num. 9, p. 1272https://doi.org/10.3390/biomedicines9091272cc by (c) Gámez Valero, Ana et al, 2021http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1805032026-05-27T06:46:51Z
dc.title.none.fl_str_mv Platelet miRNA Biosignature Discriminates between Dementia with Lewy Bodies and Alzheimer’s Disease
title Platelet miRNA Biosignature Discriminates between Dementia with Lewy Bodies and Alzheimer’s Disease
spellingShingle Platelet miRNA Biosignature Discriminates between Dementia with Lewy Bodies and Alzheimer’s Disease
Gámez Valero, Ana
Micro RNAs
Demència senil
Malaltia d'Alzheimer
Micro RNAs
Senile dementia
Alzheimer's disease
title_short Platelet miRNA Biosignature Discriminates between Dementia with Lewy Bodies and Alzheimer’s Disease
title_full Platelet miRNA Biosignature Discriminates between Dementia with Lewy Bodies and Alzheimer’s Disease
title_fullStr Platelet miRNA Biosignature Discriminates between Dementia with Lewy Bodies and Alzheimer’s Disease
title_full_unstemmed Platelet miRNA Biosignature Discriminates between Dementia with Lewy Bodies and Alzheimer’s Disease
title_sort Platelet miRNA Biosignature Discriminates between Dementia with Lewy Bodies and Alzheimer’s Disease
dc.creator.none.fl_str_mv Gámez Valero, Ana
Campdelacreu i Fumadó, Jaume
Vilas, Dolores
Ispierto, Lourdes
Gascón-Bayarri, Jordi
Reñé Ramírez, Ramon
Álvarez, Ramiro
Armengol, Maria P.
Borràs i Serres, Francesc Enric
Beyer, Katrin
author Gámez Valero, Ana
author_facet Gámez Valero, Ana
Campdelacreu i Fumadó, Jaume
Vilas, Dolores
Ispierto, Lourdes
Gascón-Bayarri, Jordi
Reñé Ramírez, Ramon
Álvarez, Ramiro
Armengol, Maria P.
Borràs i Serres, Francesc Enric
Beyer, Katrin
author_role author
author2 Campdelacreu i Fumadó, Jaume
Vilas, Dolores
Ispierto, Lourdes
Gascón-Bayarri, Jordi
Reñé Ramírez, Ramon
Álvarez, Ramiro
Armengol, Maria P.
Borràs i Serres, Francesc Enric
Beyer, Katrin
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Micro RNAs
Demència senil
Malaltia d'Alzheimer
Micro RNAs
Senile dementia
Alzheimer's disease
topic Micro RNAs
Demència senil
Malaltia d'Alzheimer
Micro RNAs
Senile dementia
Alzheimer's disease
description Dementia with Lewy bodies (DLB) is one of the most common causes of degenerative dementia, after Alzheimer's disease (AD), and presents pathological and clinical overlap with both AD and Parkinson's disease (PD). Consequently, only one in three DLB cases is diagnosed correctly. Platelets, previously related to neurodegeneration, contain microRNAs (miRNAs) whose analysis may provide disease biomarkers. Here, we profiled the whole platelet miRNA transcriptome from DLB patients and healthy controls. Differentially expressed miRNAs were further validated in three consecutive studies from 2017 to 2019 enrolling 162 individuals, including DLB, AD, and PD patients, and healthy controls. Results comprised a seven-miRNA biosignature, showing the highest diagnostic potential for the differentiation between DLB and AD. Additionally, compared to controls, two miRNAs were down-regulated in DLB, four miRNAs were up-regulated in AD, and two miRNAs were down-regulated in PD. Predictive target analysis identified three disease-specific clusters of pathways as a result of platelet-miRNA deregulation. Our cross-sectional study assesses the identification of a novel, highly specific and sensitive platelet-associated miRNA-based biosignature, which distinguishes DLB from AD.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/180503
url https://hdl.handle.net/2445/180503
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/biomedicines9091272
Biomedicines, 2021, vol. 9, num. 9, p. 1272
https://doi.org/10.3390/biomedicines9091272
dc.rights.none.fl_str_mv cc by (c) Gámez Valero, Ana et al, 2021
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Gámez Valero, Ana et al, 2021
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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