Post-Translational Modifications of Cytochrome c in Cell Life and Disease

Mitochondria are the powerhouses of the cell, whilst their malfunction is related to several human pathologies, including neurodegenerative diseases, cardiovascular diseases, and various types of cancer. In mitochondrial metabolism, cytochrome c is a small soluble heme protein that acts as an essent...

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Autores: Guerra Castellano, Alejandra, Márquez Escudero, Inmaculada, Pérez Mejías, Gonzalo, Díaz Quintana, Antonio Jesús, Rosa Acosta, Miguel Ángel de la, Díaz Moreno, Irene
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/107282
Acceso en línea:https://hdl.handle.net/11441/107282
https://doi.org/10.3390/ijms21228483
Access Level:acceso abierto
Palabra clave:cytochrome c
mitochondrial diseases
post-translational modifications
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spelling Post-Translational Modifications of Cytochrome c in Cell Life and DiseaseGuerra Castellano, AlejandraMárquez Escudero, InmaculadaPérez Mejías, GonzaloDíaz Quintana, Antonio JesúsRosa Acosta, Miguel Ángel de laDíaz Moreno, Irenecytochrome cmitochondrial diseasespost-translational modificationsMitochondria are the powerhouses of the cell, whilst their malfunction is related to several human pathologies, including neurodegenerative diseases, cardiovascular diseases, and various types of cancer. In mitochondrial metabolism, cytochrome c is a small soluble heme protein that acts as an essential redox carrier in the respiratory electron transport chain. However, cytochrome c is likewise an essential protein in the cytoplasm acting as an activator of programmed cell death. Such a dual role of cytochrome c in cell life and death is indeed fine-regulated by a wide variety of protein post-translational modifications. In this work, we show how these modifications can alter cytochrome c structure and functionality, thus emerging as a control mechanism of cell metabolism but also as a key element in development and prevention of pathologiesEuropa, FEDER [PGC2018-096049-B-I00)España Junta de Andalucía [BIO-198, US-1254317, US-1257019 and P18-FR-3487),MDPIBioquímica Vegetal y Biología MolecularEuropean Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER)Junta de Andalucía2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/107282https://doi.org/10.3390/ijms21228483reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésInternational Journal of Molecular Science, 21 (22), 8483.PGC2018-096049-B-I00BIO-198, US-1254317, US-1257019 and P18-FR-3487http://dx.doi.org/10.3390/ijms21228483info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1072822026-06-17T12:51:07Z
dc.title.none.fl_str_mv Post-Translational Modifications of Cytochrome c in Cell Life and Disease
title Post-Translational Modifications of Cytochrome c in Cell Life and Disease
spellingShingle Post-Translational Modifications of Cytochrome c in Cell Life and Disease
Guerra Castellano, Alejandra
cytochrome c
mitochondrial diseases
post-translational modifications
title_short Post-Translational Modifications of Cytochrome c in Cell Life and Disease
title_full Post-Translational Modifications of Cytochrome c in Cell Life and Disease
title_fullStr Post-Translational Modifications of Cytochrome c in Cell Life and Disease
title_full_unstemmed Post-Translational Modifications of Cytochrome c in Cell Life and Disease
title_sort Post-Translational Modifications of Cytochrome c in Cell Life and Disease
dc.creator.none.fl_str_mv Guerra Castellano, Alejandra
Márquez Escudero, Inmaculada
Pérez Mejías, Gonzalo
Díaz Quintana, Antonio Jesús
Rosa Acosta, Miguel Ángel de la
Díaz Moreno, Irene
author Guerra Castellano, Alejandra
author_facet Guerra Castellano, Alejandra
Márquez Escudero, Inmaculada
Pérez Mejías, Gonzalo
Díaz Quintana, Antonio Jesús
Rosa Acosta, Miguel Ángel de la
Díaz Moreno, Irene
author_role author
author2 Márquez Escudero, Inmaculada
Pérez Mejías, Gonzalo
Díaz Quintana, Antonio Jesús
Rosa Acosta, Miguel Ángel de la
Díaz Moreno, Irene
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Bioquímica Vegetal y Biología Molecular
European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER)
Junta de Andalucía
dc.subject.none.fl_str_mv cytochrome c
mitochondrial diseases
post-translational modifications
topic cytochrome c
mitochondrial diseases
post-translational modifications
description Mitochondria are the powerhouses of the cell, whilst their malfunction is related to several human pathologies, including neurodegenerative diseases, cardiovascular diseases, and various types of cancer. In mitochondrial metabolism, cytochrome c is a small soluble heme protein that acts as an essential redox carrier in the respiratory electron transport chain. However, cytochrome c is likewise an essential protein in the cytoplasm acting as an activator of programmed cell death. Such a dual role of cytochrome c in cell life and death is indeed fine-regulated by a wide variety of protein post-translational modifications. In this work, we show how these modifications can alter cytochrome c structure and functionality, thus emerging as a control mechanism of cell metabolism but also as a key element in development and prevention of pathologies
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/107282
https://doi.org/10.3390/ijms21228483
url https://hdl.handle.net/11441/107282
https://doi.org/10.3390/ijms21228483
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International Journal of Molecular Science, 21 (22), 8483.
PGC2018-096049-B-I00
BIO-198, US-1254317, US-1257019 and P18-FR-3487
http://dx.doi.org/10.3390/ijms21228483
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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