In vitro-in vivo correlation of drug release profiles from medicated contact lenses using an in vitro eye blink model

There is still a paucity of information on how in vitro release profiles from drug-loaded contact lenses (CLs) recorded in 3D printed eye models correlate with in vivo profiles. This work aims to evaluate the release profiles of two drug-loaded CLs in a 3D in vitro eye blink model and compare the ob...

Descripción completa

Detalles Bibliográficos
Autores: Pereira-da-Mota, A.F., Vivero-Lopez, M., Garg, P., Phan, C.-M., Concheiro Nine, Ángel, Jones, L., Alvarez-Lorenzo, C.
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Servizo Galego de Saúde (SERGAS)
Repositorio:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/21623
Acceso en línea:https://portalcientifico.sergas.gal//documentos/63b0d9710f8bcd1826d03203
http://hdl.handle.net/20.500.11940/21623
Access Level:acceso abierto
Palabra clave:Animals
Contact Lenses, Hydrophilic
Drug Liberation
Pravastatin
Resveratrol
Eye
Drug Delivery Systems
id ES_39aaa85358e2a0b888bc22abc0af0a7f
oai_identifier_str oai:runa.sergas.gal:20.500.11940/21623
network_acronym_str ES
network_name_str España
repository_id_str
spelling In vitro-in vivo correlation of drug release profiles from medicated contact lenses using an in vitro eye blink modelPereira-da-Mota, A.F.Vivero-Lopez, M.Garg, P.Phan, C.-M.Concheiro Nine, ÁngelJones, L.Alvarez-Lorenzo, C.AnimalsContact Lenses, HydrophilicDrug LiberationPravastatinResveratrolEyeDrug Delivery SystemsThere is still a paucity of information on how in vitro release profiles from drug-loaded contact lenses (CLs) recorded in 3D printed eye models correlate with in vivo profiles. This work aims to evaluate the release profiles of two drug-loaded CLs in a 3D in vitro eye blink model and compare the obtained results with the release in a vial and the drug levels in tear fluid previously obtained from an animal in vivo study. In vitro release in the eye model was tested at two different flow rates (5 and 10 µL/min) and a blink speed of 1 blink/10 s. Model CLs were loaded with two different drugs, hydrophilic pravastatin and hydrophobic resveratrol. The release of both drugs was more sustained and lower in the 3D eye model compared to the in vitro release in vials. Interestingly, both drugs presented similar release patterns in the eye model and in vivo, although the total amount of drugs released in the eye model was significantly lower, especially for resveratrol. Strong correlations between percentages of pravastatin released in the eye model and in vivo were found. These findings suggest that the current 3D printed eye blink model could be a useful tool to measure the release of ophthalmic drugs from medicated CLs. Nevertheless, physiological parameters such as the composition of the tear fluid and eyeball surface, tear flow rates, and temperature should be optimized in further studies. Graphical abstract: [Figure not available: see fulltext.].2023info:eu-repo/semantics/articlehttps://portalcientifico.sergas.gal//documentos/63b0d9710f8bcd1826d03203http://hdl.handle.net/20.500.11940/21623reponame:RUNA. Repositorio da Consellería de Sanidade e Sergasinstname:Servizo Galego de Saúde (SERGAS)Ingléshttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:runa.sergas.gal:20.500.11940/216232026-06-12T08:40:47Z
dc.title.none.fl_str_mv In vitro-in vivo correlation of drug release profiles from medicated contact lenses using an in vitro eye blink model
title In vitro-in vivo correlation of drug release profiles from medicated contact lenses using an in vitro eye blink model
spellingShingle In vitro-in vivo correlation of drug release profiles from medicated contact lenses using an in vitro eye blink model
Pereira-da-Mota, A.F.
Animals
Contact Lenses, Hydrophilic
Drug Liberation
Pravastatin
Resveratrol
Eye
Drug Delivery Systems
title_short In vitro-in vivo correlation of drug release profiles from medicated contact lenses using an in vitro eye blink model
title_full In vitro-in vivo correlation of drug release profiles from medicated contact lenses using an in vitro eye blink model
title_fullStr In vitro-in vivo correlation of drug release profiles from medicated contact lenses using an in vitro eye blink model
title_full_unstemmed In vitro-in vivo correlation of drug release profiles from medicated contact lenses using an in vitro eye blink model
title_sort In vitro-in vivo correlation of drug release profiles from medicated contact lenses using an in vitro eye blink model
dc.creator.none.fl_str_mv Pereira-da-Mota, A.F.
Vivero-Lopez, M.
Garg, P.
Phan, C.-M.
Concheiro Nine, Ángel
Jones, L.
Alvarez-Lorenzo, C.
author Pereira-da-Mota, A.F.
author_facet Pereira-da-Mota, A.F.
Vivero-Lopez, M.
Garg, P.
Phan, C.-M.
Concheiro Nine, Ángel
Jones, L.
Alvarez-Lorenzo, C.
author_role author
author2 Vivero-Lopez, M.
Garg, P.
Phan, C.-M.
Concheiro Nine, Ángel
Jones, L.
Alvarez-Lorenzo, C.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Animals
Contact Lenses, Hydrophilic
Drug Liberation
Pravastatin
Resveratrol
Eye
Drug Delivery Systems
topic Animals
Contact Lenses, Hydrophilic
Drug Liberation
Pravastatin
Resveratrol
Eye
Drug Delivery Systems
description There is still a paucity of information on how in vitro release profiles from drug-loaded contact lenses (CLs) recorded in 3D printed eye models correlate with in vivo profiles. This work aims to evaluate the release profiles of two drug-loaded CLs in a 3D in vitro eye blink model and compare the obtained results with the release in a vial and the drug levels in tear fluid previously obtained from an animal in vivo study. In vitro release in the eye model was tested at two different flow rates (5 and 10 µL/min) and a blink speed of 1 blink/10 s. Model CLs were loaded with two different drugs, hydrophilic pravastatin and hydrophobic resveratrol. The release of both drugs was more sustained and lower in the 3D eye model compared to the in vitro release in vials. Interestingly, both drugs presented similar release patterns in the eye model and in vivo, although the total amount of drugs released in the eye model was significantly lower, especially for resveratrol. Strong correlations between percentages of pravastatin released in the eye model and in vivo were found. These findings suggest that the current 3D printed eye blink model could be a useful tool to measure the release of ophthalmic drugs from medicated CLs. Nevertheless, physiological parameters such as the composition of the tear fluid and eyeball surface, tear flow rates, and temperature should be optimized in further studies. Graphical abstract: [Figure not available: see fulltext.].
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://portalcientifico.sergas.gal//documentos/63b0d9710f8bcd1826d03203
http://hdl.handle.net/20.500.11940/21623
url https://portalcientifico.sergas.gal//documentos/63b0d9710f8bcd1826d03203
http://hdl.handle.net/20.500.11940/21623
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:RUNA. Repositorio da Consellería de Sanidade e Sergas
instname:Servizo Galego de Saúde (SERGAS)
instname_str Servizo Galego de Saúde (SERGAS)
reponame_str RUNA. Repositorio da Consellería de Sanidade e Sergas
collection RUNA. Repositorio da Consellería de Sanidade e Sergas
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869406184932376576
score 15,812429

Similares en LA Referencia