Production of copper loaded lipid microparticles by PGSS® (particles from gas saturated solutions) process

Production of lipid particles loaded with metal nanoparticles by supercritical fluids based processes has been barely studied. In this work, copper nanoparticles were loaded into glyceryl palmitostearate microparticles by PGSS® (Particles from Gas Saturated Solutions). The effect of different variab...

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Detalles Bibliográficos
Autores: Martín, Victor, Gonçalves, Vanessa Santos Silva, Rodríguez Rojo, Soraya, Nunes, Daniela, Fortunato, Elvira, Martins, Rodrigo, Cocero Alonso, María José, Duarte, Catarina M.M.
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/31443
Acceso en línea:https://doi.org/10.1016/j.supflu.2017.09.001
http://uvadoc.uva.es/handle/10324/31443
Access Level:acceso abierto
Palabra clave:PGSS
Copper nanoparticles encapsulation
Lipid microparticles
Dispersion
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spelling Production of copper loaded lipid microparticles by PGSS® (particles from gas saturated solutions) processMartín, VictorGonçalves, Vanessa Santos SilvaRodríguez Rojo, SorayaNunes, DanielaFortunato, ElviraMartins, RodrigoCocero Alonso, María JoséDuarte, Catarina M.M.PGSSCopper nanoparticles encapsulationLipid microparticlesDispersionProduction of lipid particles loaded with metal nanoparticles by supercritical fluids based processes has been barely studied. In this work, copper nanoparticles were loaded into glyceryl palmitostearate microparticles by PGSS® (Particles from Gas Saturated Solutions). The effect of different variables, temperature (60-80 ºC), copper load (0.2-5%w/w) and water addition (0 – 40%w/w), in particle size and encapsulation efficiency has been studied. The dispersion of metal nanoparticles in the lipid has been determined by SEM-FIB coupled with EDS mapping. In all cases, mean particle size values lower than 70 μm have been obtained, and encapsulation efficiencies around 60% have been achieved. The addition of water has no negative effect in encapsulation efficiency nor in nanoparticles dispersion within the lipid microparticle, being important since nanoparticles are commonly synthetized in aqueous medium.2020-01-102020-01-10Ministerio de Ciencia e Innovación and the University of Valladolid (JCI-2012-14992)Fundação para a Ciência e a Tecnologia (FCT) (Grant PEst-OE/EQB/LA0004/2011: SFRH/BD/77350/2011)Fundação para a Ciência e a Tecnologia (FCT) and FEDER 2014-2020 iNOVA4Health – UID/Multi/04462/2013 and UID/Multi/04551/2013 (GreenIT)Elsevier B.V.2018info:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.1016/j.supflu.2017.09.001http://uvadoc.uva.es/handle/10324/31443reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://www.sciencedirect.com/science/article/pii/S0896844617303790info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:uvadoc.uva.es:10324/314432026-06-13T12:44:47Z
dc.title.none.fl_str_mv Production of copper loaded lipid microparticles by PGSS® (particles from gas saturated solutions) process
title Production of copper loaded lipid microparticles by PGSS® (particles from gas saturated solutions) process
spellingShingle Production of copper loaded lipid microparticles by PGSS® (particles from gas saturated solutions) process
Martín, Victor
PGSS
Copper nanoparticles encapsulation
Lipid microparticles
Dispersion
title_short Production of copper loaded lipid microparticles by PGSS® (particles from gas saturated solutions) process
title_full Production of copper loaded lipid microparticles by PGSS® (particles from gas saturated solutions) process
title_fullStr Production of copper loaded lipid microparticles by PGSS® (particles from gas saturated solutions) process
title_full_unstemmed Production of copper loaded lipid microparticles by PGSS® (particles from gas saturated solutions) process
title_sort Production of copper loaded lipid microparticles by PGSS® (particles from gas saturated solutions) process
dc.creator.none.fl_str_mv Martín, Victor
Gonçalves, Vanessa Santos Silva
Rodríguez Rojo, Soraya
Nunes, Daniela
Fortunato, Elvira
Martins, Rodrigo
Cocero Alonso, María José
Duarte, Catarina M.M.
author Martín, Victor
author_facet Martín, Victor
Gonçalves, Vanessa Santos Silva
Rodríguez Rojo, Soraya
Nunes, Daniela
Fortunato, Elvira
Martins, Rodrigo
Cocero Alonso, María José
Duarte, Catarina M.M.
author_role author
author2 Gonçalves, Vanessa Santos Silva
Rodríguez Rojo, Soraya
Nunes, Daniela
Fortunato, Elvira
Martins, Rodrigo
Cocero Alonso, María José
Duarte, Catarina M.M.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv PGSS
Copper nanoparticles encapsulation
Lipid microparticles
Dispersion
topic PGSS
Copper nanoparticles encapsulation
Lipid microparticles
Dispersion
description Production of lipid particles loaded with metal nanoparticles by supercritical fluids based processes has been barely studied. In this work, copper nanoparticles were loaded into glyceryl palmitostearate microparticles by PGSS® (Particles from Gas Saturated Solutions). The effect of different variables, temperature (60-80 ºC), copper load (0.2-5%w/w) and water addition (0 – 40%w/w), in particle size and encapsulation efficiency has been studied. The dispersion of metal nanoparticles in the lipid has been determined by SEM-FIB coupled with EDS mapping. In all cases, mean particle size values lower than 70 μm have been obtained, and encapsulation efficiencies around 60% have been achieved. The addition of water has no negative effect in encapsulation efficiency nor in nanoparticles dispersion within the lipid microparticle, being important since nanoparticles are commonly synthetized in aqueous medium.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://doi.org/10.1016/j.supflu.2017.09.001
http://uvadoc.uva.es/handle/10324/31443
url https://doi.org/10.1016/j.supflu.2017.09.001
http://uvadoc.uva.es/handle/10324/31443
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.sciencedirect.com/science/article/pii/S0896844617303790
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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