Routing of Kv7.1 to endoplasmic reticulum plasma membrane junctions

[Aim]]: The voltage-gated Kv7.1 channel, in association with the regulatory subunit KCNE1, contributes to the IKs current in the heart. However, both proteins travel to the plasma membrane using different routes. While KCNE1 follows a classical Golgi-mediated anterograde pathway, Kv7.1 is located in...

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Detalles Bibliográficos
Autores: Serrano-Novillo, Clara, Estadella, Irene, Navarro-Pérez, María, Oliveras, Anna, Benito-Bueno, Ángela de, Socuéllamos, Paula G., Bosch, Manel, Coronado, María José, Sastre, Daniel, Valenzuela, Carmen, Soeller, Christian, Felipe, Antonio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/363839
Acceso en línea:http://hdl.handle.net/10261/363839
Access Level:acceso abierto
Palabra clave:Adaptors
Cell surface targeting
ERPMj inducers
Potassium channels
Descripción
Sumario:[Aim]]: The voltage-gated Kv7.1 channel, in association with the regulatory subunit KCNE1, contributes to the IKs current in the heart. However, both proteins travel to the plasma membrane using different routes. While KCNE1 follows a classical Golgi-mediated anterograde pathway, Kv7.1 is located in endoplasmic reticulum-plasma membrane junctions (ER-PMjs), where it associates with KCNE1 before being delivered to the plasma membrane.

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