Conversion of Hydroxyproline “Doubly Customizable Units” to Hexahydropyrimidines: Access to Conformationally Constrained Peptides
The efficient transformation of hydroxyproline “doubly customizable units” into rigid hexahydropyrimidine units takes place in good global yields and generates compounds of pharmaceutical interest. In particular, the process can readily provide access to peptidomimetics and peptides with reversed se...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/331618 |
| Acceso en línea: | http://hdl.handle.net/10261/331618 |
| Access Level: | acceso abierto |
| Palabra clave: | Hydroxyproline doubly customizable units hexahydropyrimidines conformationally constrained peptides |
| Sumario: | The efficient transformation of hydroxyproline “doubly customizable units” into rigid hexahydropyrimidine units takes place in good global yields and generates compounds of pharmaceutical interest. In particular, the process can readily provide access to peptidomimetics and peptides with reversed sequences or with valuable turns. |
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