Improving the sensitivity of liquid chromatography-tandem mass spectrometry analysis of hexabromocyclododecanes by chlorine adduct generation

8 pages, 4 figures, 4 tables

Detalles Bibliográficos
Autores: Galindo-Iranzo, Plácido, Quintanilla-López, Jesús Eduardo, Lebrón-Aguilar, Rosa, Gómara, Belén
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2009
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/415344
Acceso en línea:http://hdl.handle.net/10261/415344
https://api.elsevier.com/content/abstract/scopus_id/63449129900
Access Level:acceso abierto
Palabra clave:Adduct formation
Hexabromocyclododecane
Liquid chromatography
Tandem mass spectrometry
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spelling Improving the sensitivity of liquid chromatography-tandem mass spectrometry analysis of hexabromocyclododecanes by chlorine adduct generationGalindo-Iranzo, PlácidoQuintanilla-López, Jesús EduardoLebrón-Aguilar, RosaGómara, BelénAdduct formationHexabromocyclododecaneLiquid chromatographyTandem mass spectrometry8 pages, 4 figures, 4 tablesIt is well documented and experimentally confirmed that hexabromocyclododecanes (HBCDs) tend to associate with several anions forming different adducts that can affect the sensitivity and the accuracy of the determinations. In the present work, two different approaches for HBCD determination have been optimised and characterised based on their repeatability and intermediate precision, linear calibration ranges, sensitivity, limits of detection and quantification and application to commercial food samples. Both methods involve the use of a triple quadrupole mass spectrometer coupled to a liquid chromatograph and the addition of different ammonium salts to the mobile phase, i.e. ammonium chloride or ammonium acetate, in order to encourage (Cl method) or try to inhibit (Ac method), respectively, the formation of the chlorine adducts of the molecular ion. Precision of the two methods investigated was similar and both approaches presented a comparable behaviour for the analysis of food samples. However, the Cl method showed higher sensitivity and the limits of detection (0.23-0.41 pg on column) and quantification (0.77-1.35 pg on column) were up to 14 times lower than those obtained applying the Ac method. All these facts make the Cl method the best choice for the quantification of HBCDs in food samples with low concentration levels.B.G. wishes to thank I3P program (CSIC) for her post-doctoral grant. Authors thank Laura Herrero for sample treatment and the staff of CEDEX (Madrid, Spain) for making possible the use of their LC–MS instrument. Financial support was obtained from projects CM (S-AGR-000312-0505) and CM-CSIC (CCG07-CSIC/PPQ-2135).Peer reviewedElsevierConsejo Superior de Investigaciones Científicas (España)Comunidad de Madrid#NODATA##NODATA##NODATA##NODATA#Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202620262009info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/415344https://api.elsevier.com/content/abstract/scopus_id/63449129900reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1016/j.chroma.2009.02.086Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4153442026-05-22T06:33:51Z
dc.title.none.fl_str_mv Improving the sensitivity of liquid chromatography-tandem mass spectrometry analysis of hexabromocyclododecanes by chlorine adduct generation
title Improving the sensitivity of liquid chromatography-tandem mass spectrometry analysis of hexabromocyclododecanes by chlorine adduct generation
spellingShingle Improving the sensitivity of liquid chromatography-tandem mass spectrometry analysis of hexabromocyclododecanes by chlorine adduct generation
Galindo-Iranzo, Plácido
Adduct formation
Hexabromocyclododecane
Liquid chromatography
Tandem mass spectrometry
title_short Improving the sensitivity of liquid chromatography-tandem mass spectrometry analysis of hexabromocyclododecanes by chlorine adduct generation
title_full Improving the sensitivity of liquid chromatography-tandem mass spectrometry analysis of hexabromocyclododecanes by chlorine adduct generation
title_fullStr Improving the sensitivity of liquid chromatography-tandem mass spectrometry analysis of hexabromocyclododecanes by chlorine adduct generation
title_full_unstemmed Improving the sensitivity of liquid chromatography-tandem mass spectrometry analysis of hexabromocyclododecanes by chlorine adduct generation
title_sort Improving the sensitivity of liquid chromatography-tandem mass spectrometry analysis of hexabromocyclododecanes by chlorine adduct generation
dc.creator.none.fl_str_mv Galindo-Iranzo, Plácido
Quintanilla-López, Jesús Eduardo
Lebrón-Aguilar, Rosa
Gómara, Belén
author Galindo-Iranzo, Plácido
author_facet Galindo-Iranzo, Plácido
Quintanilla-López, Jesús Eduardo
Lebrón-Aguilar, Rosa
Gómara, Belén
author_role author
author2 Quintanilla-López, Jesús Eduardo
Lebrón-Aguilar, Rosa
Gómara, Belén
author2_role author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas (España)
Comunidad de Madrid
#NODATA#
#NODATA#
#NODATA#
#NODATA#
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Adduct formation
Hexabromocyclododecane
Liquid chromatography
Tandem mass spectrometry
topic Adduct formation
Hexabromocyclododecane
Liquid chromatography
Tandem mass spectrometry
description 8 pages, 4 figures, 4 tables
publishDate 2009
dc.date.none.fl_str_mv 2009
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/415344
https://api.elsevier.com/content/abstract/scopus_id/63449129900
url http://hdl.handle.net/10261/415344
https://api.elsevier.com/content/abstract/scopus_id/63449129900
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1016/j.chroma.2009.02.086
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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