Association between free thyroxine levels and clinical phenotype in first-episode psychosis

To determine whether thyroid hormone levels are associated with a specific clinical phenotype in patients with first-episode psychosis (FEP). Ninety-eight inpatients experiencing FEP and with less than 6 weeks of antipsychotic treatment were included in the study and were followed up for one year. B...

ver descrição completa

Detalhes bibliográficos
Autores: Giné Serven, Eloi|||0000-0002-3130-5566, Martinez-Ramirez, Maria|||0000-0003-0754-4011, Boix-Quintana, Ester|||0000-0002-5542-2871, Davi-Loscos, Eva|||0000-0001-8478-9229, Guanyabens Busca, Nicolau|||0000-0002-2074-2744, Casado, Virginia|||0000-0002-3079-8776, Muriana, Desiree|||0000-0002-8919-7238, Torres-Rivas, Cristina|||0000-0001-9173-5843, Cuesta, M.J., Labad, Javier|||0000-0003-2214-1886
Formato: artículo
Fecha de publicación:2023
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:307985
Acesso em linha:https://ddd.uab.cat/record/307985
https://dx.doi.org/urn:doi:10.7717/peerj.15347
Access Level:acceso abierto
Palavra-chave:Biomarkers
First episode
Psychosis
Thyroid
TSH
FT4
Thyroxine
Schizophrenia
Schizoaffective
Bipolar disorder
id ES_391b3382f4e23bbc94080d33e7e6967a
oai_identifier_str oai:ddd.uab.cat:307985
network_acronym_str ES
network_name_str España
repository_id_str
spelling Association between free thyroxine levels and clinical phenotype in first-episode psychosisa prospective observational studyGiné Serven, Eloi|||0000-0002-3130-5566Martinez-Ramirez, Maria|||0000-0003-0754-4011Boix-Quintana, Ester|||0000-0002-5542-2871Davi-Loscos, Eva|||0000-0001-8478-9229Guanyabens Busca, Nicolau|||0000-0002-2074-2744Casado, Virginia|||0000-0002-3079-8776Muriana, Desiree|||0000-0002-8919-7238Torres-Rivas, Cristina|||0000-0001-9173-5843Cuesta, M.J.Labad, Javier|||0000-0003-2214-1886BiomarkersFirst episodePsychosisThyroidTSHFT4ThyroxineSchizophreniaSchizoaffectiveBipolar disorderTo determine whether thyroid hormone levels are associated with a specific clinical phenotype in patients with first-episode psychosis (FEP). Ninety-eight inpatients experiencing FEP and with less than 6 weeks of antipsychotic treatment were included in the study and were followed up for one year. Baseline psychiatric evaluation included assessment of prodromal symptoms, positive and negative symptoms, depressive symptoms, stressful life events and cycloid psychosis criteria. Thyroid function (thyroid-stimulating hormone (TSH) and free thyroxin (FT4)) was determined at admission. Partial correlation analysis was conducted to analyse the correlation between levels of TSH/FT4 and symptoms. Logistic regression was performed to explore the association between psychopathological symptoms, 12-month diagnoses and thyroid hormones while adjusting for covariates. Patients with prodromal symptomatology showed lower baseline FT4 levels (OR = 0.06; p = 0.018). The duration of untreated psychosis (DUP) was inversely associated with FT4 concentrations (r = - 0.243; p = 0.039). FEP patients with sudden onset of psychotic symptoms (criteria B, cycloid psychosis) showed higher FT4 levels at admission (OR = 10.49; p = 0.040). Patients diagnosed with affective psychotic disorders (BD or MDD) at the 12-month follow-up showed higher FT4 levels at admission than patients diagnosed with nonaffective psychosis (schizophrenia, schizoaffective) (OR = 8.57; p = 0.042). Our study suggests that higher free-thyroxine levels are associated with a specific clinical phenotype of FEP patients (fewer prodromal symptoms, shorter DUP duration and sudden onset of psychosis) and with affective psychosis diagnoses at the 12-month follow-up.Universitat Autònoma de Barcelona 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/307985https://dx.doi.org/urn:doi:10.7717/peerj.15347reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3079852026-06-06T12:50:31Z
dc.title.none.fl_str_mv Association between free thyroxine levels and clinical phenotype in first-episode psychosis
a prospective observational study
title Association between free thyroxine levels and clinical phenotype in first-episode psychosis
spellingShingle Association between free thyroxine levels and clinical phenotype in first-episode psychosis
Giné Serven, Eloi|||0000-0002-3130-5566
Biomarkers
First episode
Psychosis
Thyroid
TSH
FT4
Thyroxine
Schizophrenia
Schizoaffective
Bipolar disorder
title_short Association between free thyroxine levels and clinical phenotype in first-episode psychosis
title_full Association between free thyroxine levels and clinical phenotype in first-episode psychosis
title_fullStr Association between free thyroxine levels and clinical phenotype in first-episode psychosis
title_full_unstemmed Association between free thyroxine levels and clinical phenotype in first-episode psychosis
title_sort Association between free thyroxine levels and clinical phenotype in first-episode psychosis
dc.creator.none.fl_str_mv Giné Serven, Eloi|||0000-0002-3130-5566
Martinez-Ramirez, Maria|||0000-0003-0754-4011
Boix-Quintana, Ester|||0000-0002-5542-2871
Davi-Loscos, Eva|||0000-0001-8478-9229
Guanyabens Busca, Nicolau|||0000-0002-2074-2744
Casado, Virginia|||0000-0002-3079-8776
Muriana, Desiree|||0000-0002-8919-7238
Torres-Rivas, Cristina|||0000-0001-9173-5843
Cuesta, M.J.
Labad, Javier|||0000-0003-2214-1886
author Giné Serven, Eloi|||0000-0002-3130-5566
author_facet Giné Serven, Eloi|||0000-0002-3130-5566
Martinez-Ramirez, Maria|||0000-0003-0754-4011
Boix-Quintana, Ester|||0000-0002-5542-2871
Davi-Loscos, Eva|||0000-0001-8478-9229
Guanyabens Busca, Nicolau|||0000-0002-2074-2744
Casado, Virginia|||0000-0002-3079-8776
Muriana, Desiree|||0000-0002-8919-7238
Torres-Rivas, Cristina|||0000-0001-9173-5843
Cuesta, M.J.
Labad, Javier|||0000-0003-2214-1886
author_role author
author2 Martinez-Ramirez, Maria|||0000-0003-0754-4011
Boix-Quintana, Ester|||0000-0002-5542-2871
Davi-Loscos, Eva|||0000-0001-8478-9229
Guanyabens Busca, Nicolau|||0000-0002-2074-2744
Casado, Virginia|||0000-0002-3079-8776
Muriana, Desiree|||0000-0002-8919-7238
Torres-Rivas, Cristina|||0000-0001-9173-5843
Cuesta, M.J.
Labad, Javier|||0000-0003-2214-1886
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Biomarkers
First episode
Psychosis
Thyroid
TSH
FT4
Thyroxine
Schizophrenia
Schizoaffective
Bipolar disorder
topic Biomarkers
First episode
Psychosis
Thyroid
TSH
FT4
Thyroxine
Schizophrenia
Schizoaffective
Bipolar disorder
description To determine whether thyroid hormone levels are associated with a specific clinical phenotype in patients with first-episode psychosis (FEP). Ninety-eight inpatients experiencing FEP and with less than 6 weeks of antipsychotic treatment were included in the study and were followed up for one year. Baseline psychiatric evaluation included assessment of prodromal symptoms, positive and negative symptoms, depressive symptoms, stressful life events and cycloid psychosis criteria. Thyroid function (thyroid-stimulating hormone (TSH) and free thyroxin (FT4)) was determined at admission. Partial correlation analysis was conducted to analyse the correlation between levels of TSH/FT4 and symptoms. Logistic regression was performed to explore the association between psychopathological symptoms, 12-month diagnoses and thyroid hormones while adjusting for covariates. Patients with prodromal symptomatology showed lower baseline FT4 levels (OR = 0.06; p = 0.018). The duration of untreated psychosis (DUP) was inversely associated with FT4 concentrations (r = - 0.243; p = 0.039). FEP patients with sudden onset of psychotic symptoms (criteria B, cycloid psychosis) showed higher FT4 levels at admission (OR = 10.49; p = 0.040). Patients diagnosed with affective psychotic disorders (BD or MDD) at the 12-month follow-up showed higher FT4 levels at admission than patients diagnosed with nonaffective psychosis (schizophrenia, schizoaffective) (OR = 8.57; p = 0.042). Our study suggests that higher free-thyroxine levels are associated with a specific clinical phenotype of FEP patients (fewer prodromal symptoms, shorter DUP duration and sudden onset of psychosis) and with affective psychosis diagnoses at the 12-month follow-up.
publishDate 2023
dc.date.none.fl_str_mv 2
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/307985
https://dx.doi.org/urn:doi:10.7717/peerj.15347
url https://ddd.uab.cat/record/307985
https://dx.doi.org/urn:doi:10.7717/peerj.15347
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869406143695028224
score 15,811543

Registos relacionados