Relationship between propofol pharmacokinetic variation and haemodynamic changes during anaesthesia induction and knee-chest positioning in surgical patients with propofol TCI anaesthesia

Tesis por compendio de publicaciones

Detalles Bibliográficos
Autor: Mascarenhas Chaló, Daniela De
Tipo de recurso: tesis doctoral
Fecha de publicación:2020
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/145434
Acceso en línea:http://hdl.handle.net/10366/145434
Access Level:acceso abierto
Palabra clave:Tesis y disertaciones académicas
Universidad de Salamanca (España)
Tesis Doctoral
Academic dissertations
Farmacocinética
Propofol
Hemodinámica
Anestesia
Pharmacokinetics
3208 Farmacodinámica
3213.03 Anestesiología
farmacocinética
propofol
hemodinámica
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network_name_str España
repository_id_str
spelling Relationship between propofol pharmacokinetic variation and haemodynamic changes during anaesthesia induction and knee-chest positioning in surgical patients with propofol TCI anaesthesiaRelación entre la farmacocinética y los cambios hemodinámicos durante la inducción y posicionamiento en pacientes quirúgicos anestesiados con propofolMascarenhas Chaló, Daniela DeTesis y disertaciones académicasUniversidad de Salamanca (España)Tesis DoctoralAcademic dissertationsFarmacocinéticaPropofolHemodinámicaAnestesiaPharmacokineticsPropofol3208 Farmacodinámica3213.03 AnestesiologíafarmacocinéticapropofolhemodinámicaTesis por compendio de publicaciones[EN]For long years, it was thought that anaesthetic management did not influence patient’s outcome. Surgical morbidity and long-term mortality were attributed to patient’s comorbidity, malignance of the disease, risk infection and type of surgery. Nowadays, there is an increasing evidence that intraoperative anaesthetic management can influence long-term patient outcomes. In the last two decades, surgical mortality rates have been falling and, in part, this is due to a huge improvement in anaesthesia related factors and safety. For an anaesthesiologist, perioperative care is no longer the simple fact of administrating the anaesthetic drug and maintaining the patient “asleep”. Direct-guided fluid therapy, maintaining intraoperative normothermia, minimizing blood transfusion and avoiding low mean arterial pressure and deep hypnotic level are additional procedures the anaesthesiologist is responsible for and that will probably improve patient’s outcome and decrease surgical mortality. Hypotension after induction of anaesthesia is quite common and more prevalent during the late post-induction period and before skin incision (5-10 minutes after), generally thought to be clinically irrelevant. Nowadays, there is some evidence that small haemodynamic changes, such as hypotension, even for small periods, are associated with poor patient outcomes, because they have the potential to cause an ischemia–reperfusion injury which may be manifested as dysfunction of any vital organ, like acute kidney and myocardial injury. Intra-operative management of hypotension is usually guided by conventional monitoring (systolic blood pressure and MAP) but these parameters could mask low levels of blood flow and oxygen delivery, even for short periods, leading to major surgical complications and longer hospital stays.Sancho Sánchez, ConsueloÁlvarez-Morujo Suárez, Antonio Jesús202120212020info:eu-repo/semantics/doctoralThesishttp://hdl.handle.net/10366/145434reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1454342026-06-07T06:28:51Z
dc.title.none.fl_str_mv Relationship between propofol pharmacokinetic variation and haemodynamic changes during anaesthesia induction and knee-chest positioning in surgical patients with propofol TCI anaesthesia
Relación entre la farmacocinética y los cambios hemodinámicos durante la inducción y posicionamiento en pacientes quirúgicos anestesiados con propofol
title Relationship between propofol pharmacokinetic variation and haemodynamic changes during anaesthesia induction and knee-chest positioning in surgical patients with propofol TCI anaesthesia
spellingShingle Relationship between propofol pharmacokinetic variation and haemodynamic changes during anaesthesia induction and knee-chest positioning in surgical patients with propofol TCI anaesthesia
Mascarenhas Chaló, Daniela De
Tesis y disertaciones académicas
Universidad de Salamanca (España)
Tesis Doctoral
Academic dissertations
Farmacocinética
Propofol
Hemodinámica
Anestesia
Pharmacokinetics
Propofol
3208 Farmacodinámica
3213.03 Anestesiología
farmacocinética
propofol
hemodinámica
title_short Relationship between propofol pharmacokinetic variation and haemodynamic changes during anaesthesia induction and knee-chest positioning in surgical patients with propofol TCI anaesthesia
title_full Relationship between propofol pharmacokinetic variation and haemodynamic changes during anaesthesia induction and knee-chest positioning in surgical patients with propofol TCI anaesthesia
title_fullStr Relationship between propofol pharmacokinetic variation and haemodynamic changes during anaesthesia induction and knee-chest positioning in surgical patients with propofol TCI anaesthesia
title_full_unstemmed Relationship between propofol pharmacokinetic variation and haemodynamic changes during anaesthesia induction and knee-chest positioning in surgical patients with propofol TCI anaesthesia
title_sort Relationship between propofol pharmacokinetic variation and haemodynamic changes during anaesthesia induction and knee-chest positioning in surgical patients with propofol TCI anaesthesia
dc.creator.none.fl_str_mv Mascarenhas Chaló, Daniela De
author Mascarenhas Chaló, Daniela De
author_facet Mascarenhas Chaló, Daniela De
author_role author
dc.contributor.none.fl_str_mv Sancho Sánchez, Consuelo
Álvarez-Morujo Suárez, Antonio Jesús
dc.subject.none.fl_str_mv Tesis y disertaciones académicas
Universidad de Salamanca (España)
Tesis Doctoral
Academic dissertations
Farmacocinética
Propofol
Hemodinámica
Anestesia
Pharmacokinetics
Propofol
3208 Farmacodinámica
3213.03 Anestesiología
farmacocinética
propofol
hemodinámica
topic Tesis y disertaciones académicas
Universidad de Salamanca (España)
Tesis Doctoral
Academic dissertations
Farmacocinética
Propofol
Hemodinámica
Anestesia
Pharmacokinetics
Propofol
3208 Farmacodinámica
3213.03 Anestesiología
farmacocinética
propofol
hemodinámica
description Tesis por compendio de publicaciones
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/145434
url http://hdl.handle.net/10366/145434
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869406143201148928
score 15,300719

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