On the use of the healthy lifestyle index to investigate specific disease outcomes

The healthy lifestyle index (HLI), defined as the unweighted sum of individual lifestyle components, was used to investigate the combined role of lifestyle factors on health-related outcomes. We introduced weighted outcome-specific versions of the HLI, where individual lifestyle components were weig...

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Detalles Bibliográficos
Autores: Viallon, Vivian, Freisling, Heinz, Matta, Komodo, Nannsen, Anne Østergaard, Dahm, Christina C., Tjønneland, Anne, Eriksen, Anne Kirstine, Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B., Masala, Giovanna, Tagliabue, Giovanna, Simeon, Vittorio, Tumino, Rosario, Milani, Lorenzo, Derksen, Jeroen W. G., Van Der Schouw, Yvonne T., Nøst, Therese Haugdahl, Borch, Kristin Benjaminsen, Sandanger, Torkjel M., Quirós, José Ramón, Rodriguez-Barranco, Miguel, Bonet, Catalina, Aizpurua Atxega, Amaia, Cirera, Lluís, Guevara, Marcela, Sundström, Björn, Winkvist, Anna, Heath, Alicia K., Gunter, Marc J., Weiderpass, Elisabete, Johansson, Mattias, Ferrari, Pietro
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/215176
Acceso en línea:https://hdl.handle.net/2445/215176
Access Level:acceso abierto
Palabra clave:Malalties cardiovasculars
Diabetis no-insulinodependent
Cardiovascular diseases
Non-insulin-dependent diabetes
Descripción
Sumario:The healthy lifestyle index (HLI), defined as the unweighted sum of individual lifestyle components, was used to investigate the combined role of lifestyle factors on health-related outcomes. We introduced weighted outcome-specific versions of the HLI, where individual lifestyle components were weighted according to their associations with disease outcomes. Within the European Prospective Investigation into Cancer and Nutrition (EPIC), we examined the association between the standard and the outcome-specific HLIs and the risk of T2D, CVD, cancer, and all-cause premature mortality. Estimates of the hazard ratios (HRs), the Harrell's C-index and the population attributable fractions (PAFs) were compared. For T2D, the HR for 1-SD increase of the standard and T2D-specific HLI were 0.66 (95% CI: 0.64, 0.67) and 0.43 (0.42, 0.44), respectively, and the C-index were 0.63 (0.62, 0.64) and 0.72 (0.72, 0.73). Similar, yet less pronounced differences in HR and C-index were observed for standard and outcome-specific estimates for cancer, CVD and all-cause mortality. PAF estimates for mortality before age 80 were 57% (55%, 58%) and 33% (32%, 34%) for standard and mortality-specific HLI, respectively. The use of outcome-specific HLI could improve the assessment of the role of lifestyle factors on disease outcomes, thus enhancing the definition of public health recommendations.

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