Mirabegron induces selective changes in the faecal microbiota of HFHFr rats without altering bile acid composition
In the present work, we analyse stored liver, adipose tissue (perigonadal</p><p>and brown), serum and faecal samples from our previous study and present new</p><p>biochemical, faecal metabolomic and microbiome data.</p><p>We show that oral administration of mirabe...
| Autores: | , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/225599 |
| Acceso en línea: | https://hdl.handle.net/2445/225599 |
| Access Level: | acceso abierto |
| Palabra clave: | Metabolisme Malalties del fetge Teixit adipós Metabolism Liver diseases Adipose tissues |
| Sumario: | In the present work, we analyse stored liver, adipose tissue (perigonadal</p><p>and brown), serum and faecal samples from our previous study and present new</p><p>biochemical, faecal metabolomic and microbiome data.</p><p>We show that oral administration of mirabegron</p><p>significantly increases the expression of uncoupling protein 1 in brown</p><p>adipose tissue and β3-Adrenergic receptor protein in perigonadal white</p><p>adipose and liver tissues. Furthermore, mirabegron treatment changes the</p><p>relative abundance of several genus and families of rat faecal microbiota,</p><p>albeit without restoring the global biodiversity and evenness indexes observed</p><p>in control rats, as well as faecal bile acids composition. These changes are</p><p>probably due to a direct effect of mirabegron on the gut microbiome, rather</p><p>than being mediated by changes in bile acid induced by drug treatment. |
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