An updated overview on the relationship between human gut microbiome dysbiosis and psychiatric and psychological disorders

There is a lot of evidence establishing that nervous system development is related to the composition and functions of the gut microbiome. In addition, the central nervous system (CNS) controls the imbalance of the intestinal microbiota, constituting a bidirectional communication network. At present...

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Authors: Borrego García, Juan José, Borrego Ruiz, Alejandro
Format: article
Publication Date:2024
Country:España
Institution:Universidad Nacional de Educación a Distancia
Repository:e-spacio. Repositorio Institucional de la UNED
Language:English
OAI Identifier:oai:e-spacio.uned.es:20.500.14468/23800
Online Access:https://hdl.handle.net/20.500.14468/23800
Access Level:Open access
Keyword:61 Psicología
24 Ciencias de la Vida::2490 Neurociencias
Human microbiome
Gut microbiota
Dysbiosis
Neuropsychiatric diseases
Psychological disorders
Gut microbiota-CNS axis
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spelling An updated overview on the relationship between human gut microbiome dysbiosis and psychiatric and psychological disordersBorrego García, Juan JoséBorrego Ruiz, Alejandro61 Psicología24 Ciencias de la Vida::2490 NeurocienciasHuman microbiomeGut microbiotaDysbiosisNeuropsychiatric diseasesPsychological disordersGut microbiota-CNS axisThere is a lot of evidence establishing that nervous system development is related to the composition and functions of the gut microbiome. In addition, the central nervous system (CNS) controls the imbalance of the intestinal microbiota, constituting a bidirectional communication network. At present, various gut-brain crosstalk routes have been described, including immune, endocrine and neural circuits via the vagal pathway. Several empirical data have associated gut microbiota alterations (dysbiosis) with neuropsychiatric diseases, such as Alzheimer's disease, autism and Parkinson's disease, and with other psychological disorders, like anxiety and depression. Fecal microbiota transplantation (FMT) therapy has shown that the gut microbiota can transfer behavioral features to recipient animals, which provides strong evidence to establish a cause-effect relationship. Interventions, based on prebiotics, probiotics or synbiotics, have demonstrated an important influence of microbiota on neurological disorders by the synthesis of neuroactive compounds that interact with the nervous system and by the regulation of inflammatory and endocrine processes. Further research is needed to demonstrate the influence of gut microbiota dysbiosis on psychiatric and psychological disorders, and how microbiota-based interventions may be used as potential therapeutic tools.Elseviere-Spacio UNED20242024-09-1920242024-01-0120242024-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14468/23800reponame:e-spacio. Repositorio Institucional de la UNEDinstname:Universidad Nacional de Educación a DistanciaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.esoai:e-spacio.uned.es:20.500.14468/238002026-06-06T12:38:31Z
dc.title.none.fl_str_mv An updated overview on the relationship between human gut microbiome dysbiosis and psychiatric and psychological disorders
title An updated overview on the relationship between human gut microbiome dysbiosis and psychiatric and psychological disorders
spellingShingle An updated overview on the relationship between human gut microbiome dysbiosis and psychiatric and psychological disorders
Borrego García, Juan José
61 Psicología
24 Ciencias de la Vida::2490 Neurociencias
Human microbiome
Gut microbiota
Dysbiosis
Neuropsychiatric diseases
Psychological disorders
Gut microbiota-CNS axis
title_short An updated overview on the relationship between human gut microbiome dysbiosis and psychiatric and psychological disorders
title_full An updated overview on the relationship between human gut microbiome dysbiosis and psychiatric and psychological disorders
title_fullStr An updated overview on the relationship between human gut microbiome dysbiosis and psychiatric and psychological disorders
title_full_unstemmed An updated overview on the relationship between human gut microbiome dysbiosis and psychiatric and psychological disorders
title_sort An updated overview on the relationship between human gut microbiome dysbiosis and psychiatric and psychological disorders
dc.creator.none.fl_str_mv Borrego García, Juan José
Borrego Ruiz, Alejandro
author Borrego García, Juan José
author_facet Borrego García, Juan José
Borrego Ruiz, Alejandro
author_role author
author2 Borrego Ruiz, Alejandro
author2_role author
dc.contributor.none.fl_str_mv e-Spacio UNED
dc.subject.none.fl_str_mv 61 Psicología
24 Ciencias de la Vida::2490 Neurociencias
Human microbiome
Gut microbiota
Dysbiosis
Neuropsychiatric diseases
Psychological disorders
Gut microbiota-CNS axis
topic 61 Psicología
24 Ciencias de la Vida::2490 Neurociencias
Human microbiome
Gut microbiota
Dysbiosis
Neuropsychiatric diseases
Psychological disorders
Gut microbiota-CNS axis
description There is a lot of evidence establishing that nervous system development is related to the composition and functions of the gut microbiome. In addition, the central nervous system (CNS) controls the imbalance of the intestinal microbiota, constituting a bidirectional communication network. At present, various gut-brain crosstalk routes have been described, including immune, endocrine and neural circuits via the vagal pathway. Several empirical data have associated gut microbiota alterations (dysbiosis) with neuropsychiatric diseases, such as Alzheimer's disease, autism and Parkinson's disease, and with other psychological disorders, like anxiety and depression. Fecal microbiota transplantation (FMT) therapy has shown that the gut microbiota can transfer behavioral features to recipient animals, which provides strong evidence to establish a cause-effect relationship. Interventions, based on prebiotics, probiotics or synbiotics, have demonstrated an important influence of microbiota on neurological disorders by the synthesis of neuroactive compounds that interact with the nervous system and by the regulation of inflammatory and endocrine processes. Further research is needed to demonstrate the influence of gut microbiota dysbiosis on psychiatric and psychological disorders, and how microbiota-based interventions may be used as potential therapeutic tools.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-09-19
2024
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14468/23800
url https://hdl.handle.net/20.500.14468/23800
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:e-spacio. Repositorio Institucional de la UNED
instname:Universidad Nacional de Educación a Distancia
instname_str Universidad Nacional de Educación a Distancia
reponame_str e-spacio. Repositorio Institucional de la UNED
collection e-spacio. Repositorio Institucional de la UNED
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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