Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A Multi-Centre Population-Based Birth Cohort Study in Spain

Background: There are few studies that look at the intake of all types of omega-3 polyunsaturated fatty acids (n-3 PUFAs) during the different stages of pregnancy along with a long-term neuropsychological follow-up of the child. This study aims to explore the association between maternal n-3 PUFA in...

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Autores: Tahaei, Hana, Gignac, Florence, Pinar, Ariadna, Fernandez-Barres, Silvia, Romaguera, Dora, Vioque, Jesus, Santa-Marina, Loreto, Subiza-Perez, Mikel, Llop, Sabrina, Soler-Blasco, Raquel, Arija, Victoria, Salas-Salvado, Jordi, Tardon, Adonina, Riano-Galan, Isolina, Sunyer, Jordi, Guxens, Monica, Julvez, Jordi
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/23490
Acceso en línea:https://hdl.handle.net/20.500.12105/23490
Access Level:acceso abierto
Palabra clave:Maternal diet
Children
Neurodevelopment
Omega-3 fatty acids
Population-based cohort
Estudios de Cohortes
Preescolar
Humanos
Ácidos Grasos Omega-3
Estudios Prospectivos
Embarazo
Desarrollo Infantil
Femenino
Niño
Lactante
Efectos Tardíos de la Exposición Prenatal
España
Child
Pregnancy
Fatty Acids, Omega-3
Prospective Studies
Spain
Child Development
Female
Humans
Child, Preschool
Cohort Studies
Prenatal Exposure Delayed Effects
Infant
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spelling Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A Multi-Centre Population-Based Birth Cohort Study in SpainTahaei, HanaGignac, FlorencePinar, AriadnaFernandez-Barres, SilviaRomaguera, DoraVioque, JesusSanta-Marina, LoretoSubiza-Perez, MikelLlop, SabrinaSoler-Blasco, RaquelArija, VictoriaSalas-Salvado, JordiTardon, AdoninaRiano-Galan, IsolinaSunyer, JordiGuxens, MonicaJulvez, JordiMaternal dietChildrenNeurodevelopmentOmega-3 fatty acidsPopulation-based cohortEstudios de CohortesPreescolarHumanosÁcidos Grasos Omega-3Estudios ProspectivosEmbarazoDesarrollo InfantilFemeninoNiñoLactanteEfectos Tardíos de la Exposición PrenatalEspañaChildPregnancyFatty Acids, Omega-3Prospective StudiesSpainChild DevelopmentFemaleHumansChild, PreschoolCohort StudiesPrenatal Exposure Delayed EffectsInfantBackground: There are few studies that look at the intake of all types of omega-3 polyunsaturated fatty acids (n-3 PUFAs) during the different stages of pregnancy along with a long-term neuropsychological follow-up of the child. This study aims to explore the association between maternal n-3 PUFA intake during two periods of pregnancy and the child's neuropsychological scores at different ages. Methods: Prospective data were obtained for 2644 pregnant women recruited between 2004 and 2008 in population-based birth cohorts in Spain. Maternal n-3 PUFA intake during the first and third trimester of pregnancy was estimated using validated food frequency questionnaires. Child neuropsychological functions were assessed using Bayley Scales of Infant Development version one (BSID) at 1 year old, the McCarthy Scale of Children's Abilities (MSCA) at 4 years old, and the Attention Network Test (ANT) at 7 years old. Data were analysed using multivariate linear regression models and adjusted for potential covariates, such as maternal social class, education, cohort location, alcohol consumption, smoking, breastfeeding duration, and energy intake. Results: Compared to participants in the lowest quartile (<1.262 g/day) of n-3 PUFA consumption during the first trimester, those in the highest quartile (>1.657 g/day) had a 2.26 points (95% confidence interval (CI): 0.41, 4.11) higher MSCA general cognitive score, a 2.48 points (95% CI: 0.53, 4.43) higher MSCA verbal score, and a 2.06 points (95% CI: 0.166, 3.95) higher MSCA executive function score, and a 11.52 milliseconds (95% CI: -22.95, -0.09) lower ANT hit reaction time standard error. In the third pregnancy trimester, the associations were weaker. Conclusions: Positive associations between n-3 PUFA intake during early pregnancy and child neuropsychological functions at 4 and 7 years of age were found, and further clinical research is needed to confirm these findings.Multidisciplinary Digital Publishing Institute (MDPI)20242024-10-0420222022-02-0120222022-02-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttps://hdl.handle.net/20.500.12105/23490reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/234902026-06-12T12:43:37Z
dc.title.none.fl_str_mv Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A Multi-Centre Population-Based Birth Cohort Study in Spain
title Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A Multi-Centre Population-Based Birth Cohort Study in Spain
spellingShingle Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A Multi-Centre Population-Based Birth Cohort Study in Spain
Tahaei, Hana
Maternal diet
Children
Neurodevelopment
Omega-3 fatty acids
Population-based cohort
Estudios de Cohortes
Preescolar
Humanos
Ácidos Grasos Omega-3
Estudios Prospectivos
Embarazo
Desarrollo Infantil
Femenino
Niño
Lactante
Efectos Tardíos de la Exposición Prenatal
España
Child
Pregnancy
Fatty Acids, Omega-3
Prospective Studies
Spain
Child Development
Female
Humans
Child, Preschool
Cohort Studies
Prenatal Exposure Delayed Effects
Infant
title_short Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A Multi-Centre Population-Based Birth Cohort Study in Spain
title_full Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A Multi-Centre Population-Based Birth Cohort Study in Spain
title_fullStr Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A Multi-Centre Population-Based Birth Cohort Study in Spain
title_full_unstemmed Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A Multi-Centre Population-Based Birth Cohort Study in Spain
title_sort Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A Multi-Centre Population-Based Birth Cohort Study in Spain
dc.creator.none.fl_str_mv Tahaei, Hana
Gignac, Florence
Pinar, Ariadna
Fernandez-Barres, Silvia
Romaguera, Dora
Vioque, Jesus
Santa-Marina, Loreto
Subiza-Perez, Mikel
Llop, Sabrina
Soler-Blasco, Raquel
Arija, Victoria
Salas-Salvado, Jordi
Tardon, Adonina
Riano-Galan, Isolina
Sunyer, Jordi
Guxens, Monica
Julvez, Jordi
author Tahaei, Hana
author_facet Tahaei, Hana
Gignac, Florence
Pinar, Ariadna
Fernandez-Barres, Silvia
Romaguera, Dora
Vioque, Jesus
Santa-Marina, Loreto
Subiza-Perez, Mikel
Llop, Sabrina
Soler-Blasco, Raquel
Arija, Victoria
Salas-Salvado, Jordi
Tardon, Adonina
Riano-Galan, Isolina
Sunyer, Jordi
Guxens, Monica
Julvez, Jordi
author_role author
author2 Gignac, Florence
Pinar, Ariadna
Fernandez-Barres, Silvia
Romaguera, Dora
Vioque, Jesus
Santa-Marina, Loreto
Subiza-Perez, Mikel
Llop, Sabrina
Soler-Blasco, Raquel
Arija, Victoria
Salas-Salvado, Jordi
Tardon, Adonina
Riano-Galan, Isolina
Sunyer, Jordi
Guxens, Monica
Julvez, Jordi
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Maternal diet
Children
Neurodevelopment
Omega-3 fatty acids
Population-based cohort
Estudios de Cohortes
Preescolar
Humanos
Ácidos Grasos Omega-3
Estudios Prospectivos
Embarazo
Desarrollo Infantil
Femenino
Niño
Lactante
Efectos Tardíos de la Exposición Prenatal
España
Child
Pregnancy
Fatty Acids, Omega-3
Prospective Studies
Spain
Child Development
Female
Humans
Child, Preschool
Cohort Studies
Prenatal Exposure Delayed Effects
Infant
topic Maternal diet
Children
Neurodevelopment
Omega-3 fatty acids
Population-based cohort
Estudios de Cohortes
Preescolar
Humanos
Ácidos Grasos Omega-3
Estudios Prospectivos
Embarazo
Desarrollo Infantil
Femenino
Niño
Lactante
Efectos Tardíos de la Exposición Prenatal
España
Child
Pregnancy
Fatty Acids, Omega-3
Prospective Studies
Spain
Child Development
Female
Humans
Child, Preschool
Cohort Studies
Prenatal Exposure Delayed Effects
Infant
description Background: There are few studies that look at the intake of all types of omega-3 polyunsaturated fatty acids (n-3 PUFAs) during the different stages of pregnancy along with a long-term neuropsychological follow-up of the child. This study aims to explore the association between maternal n-3 PUFA intake during two periods of pregnancy and the child's neuropsychological scores at different ages. Methods: Prospective data were obtained for 2644 pregnant women recruited between 2004 and 2008 in population-based birth cohorts in Spain. Maternal n-3 PUFA intake during the first and third trimester of pregnancy was estimated using validated food frequency questionnaires. Child neuropsychological functions were assessed using Bayley Scales of Infant Development version one (BSID) at 1 year old, the McCarthy Scale of Children's Abilities (MSCA) at 4 years old, and the Attention Network Test (ANT) at 7 years old. Data were analysed using multivariate linear regression models and adjusted for potential covariates, such as maternal social class, education, cohort location, alcohol consumption, smoking, breastfeeding duration, and energy intake. Results: Compared to participants in the lowest quartile (<1.262 g/day) of n-3 PUFA consumption during the first trimester, those in the highest quartile (>1.657 g/day) had a 2.26 points (95% confidence interval (CI): 0.41, 4.11) higher MSCA general cognitive score, a 2.48 points (95% CI: 0.53, 4.43) higher MSCA verbal score, and a 2.06 points (95% CI: 0.166, 3.95) higher MSCA executive function score, and a 11.52 milliseconds (95% CI: -22.95, -0.09) lower ANT hit reaction time standard error. In the third pregnancy trimester, the associations were weaker. Conclusions: Positive associations between n-3 PUFA intake during early pregnancy and child neuropsychological functions at 4 and 7 years of age were found, and further clinical research is needed to confirm these findings.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-02-01
2022
2022-02-01
2024
2024-10-04
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12105/23490
url https://hdl.handle.net/20.500.12105/23490
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869406109281812480
score 15.198674

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