Microdosimetry in low energy proton beam at therapeutic-equivalent fluence rate with silicon 3D-cylindrical microdetectors
In this work we show the first microdosimetry measurements on a low energy proton beam with therapeutic-equivalent fluence rates by using the second generation of 3D-cylindrical microdetectors. The sensors belong to an improved version of a novel silicon-based 3D-microdetector design with electrodes...
| Autores: | , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad de Sevilla (US) |
| Repositorio: | idUS. Depósito de Investigación de la Universidad de Sevilla |
| OAI Identifier: | oai:idus.us.es:11441/135703 |
| Acceso en línea: | https://hdl.handle.net/11441/135703 https://doi.org/10.1088/1361-6560/abf811 |
| Access Level: | acceso abierto |
| Palabra clave: | Microdosimetry Proton therapy Silicon 3D microdetectors |
| id |
ES_3868de50a7ce2cdb83ebefd9d90d0c39 |
|---|---|
| oai_identifier_str |
oai:idus.us.es:11441/135703 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
Microdosimetry in low energy proton beam at therapeutic-equivalent fluence rate with silicon 3D-cylindrical microdetectorsGuardiola, ConsueloBachiller Perea, DianaPrieto Pena, JuanJiménez Ramos, María del CarmenGarcía López, Francisco JavierEsnault, CedricFleta Corral, María CelesteQuirión, DavidGómez Rodríguez, FaustinoMicrodosimetryProton therapySilicon 3D microdetectorsIn this work we show the first microdosimetry measurements on a low energy proton beam with therapeutic-equivalent fluence rates by using the second generation of 3D-cylindrical microdetectors. The sensors belong to an improved version of a novel silicon-based 3D-microdetector design with electrodes etched inside silicon, which were manufactured at the National Microelectronics Centre (IMB-CNM, CSIC) in Spain. A new microtechnology has been employed using quasi-toroid electrodes of 25μm diameter and a depth of 20μm within the silicon bulk, resulting in a well-defined cylindrical radiation sensitive volume. These detectors were tested at the 18 MeV proton beamline of the cyclotron at the National Accelerator Centre (CNA, Spain). They were assembled into an in-house low-noise readout electronics to assess their performance at a therapeutic-equivalent fluence rate. Microdosimetry spectra of lineal energy were recorded at several proton energies starting from 18 MeV by adding 50μm thick tungsten foils gradually at the exit-window of the cyclotron external beamline, which corresponds to different depths along the Bragg curve. The experimentalyF¯values in silicon cover from (5.7 ± 0.9) to (8.5 ± 0.4) keV μm-1in the entrance to (27.4 ± 2.3) keV μm-1in the distal edge. Pulse height energy spectra were crosschecked with Monte Carlo simulations and an excellent agreement was obtained. This work demonstrates the capability of the second generation 3D-microdetectors to assess accurate microdosimetric distributions at fluence rates as high as those used in clinical centers in proton therapy.IOP PublishingFísica Aplicada IIFísica Atómica, Molecular y NuclearRNM138: Física Nuclear AplicadaMICIN2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/135703https://doi.org/10.1088/1361-6560/abf811reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésPhysics in Medicine & Biology, 66 (11(114001))RTI2018-098117-B-C2https://iopscience.iop.org/article/10.1088/1361-6560/abf811/pdfinfo:eu-repo/semantics/openAccessoai:idus.us.es:11441/1357032026-06-17T12:51:07Z |
| dc.title.none.fl_str_mv |
Microdosimetry in low energy proton beam at therapeutic-equivalent fluence rate with silicon 3D-cylindrical microdetectors |
| title |
Microdosimetry in low energy proton beam at therapeutic-equivalent fluence rate with silicon 3D-cylindrical microdetectors |
| spellingShingle |
Microdosimetry in low energy proton beam at therapeutic-equivalent fluence rate with silicon 3D-cylindrical microdetectors Guardiola, Consuelo Microdosimetry Proton therapy Silicon 3D microdetectors |
| title_short |
Microdosimetry in low energy proton beam at therapeutic-equivalent fluence rate with silicon 3D-cylindrical microdetectors |
| title_full |
Microdosimetry in low energy proton beam at therapeutic-equivalent fluence rate with silicon 3D-cylindrical microdetectors |
| title_fullStr |
Microdosimetry in low energy proton beam at therapeutic-equivalent fluence rate with silicon 3D-cylindrical microdetectors |
| title_full_unstemmed |
Microdosimetry in low energy proton beam at therapeutic-equivalent fluence rate with silicon 3D-cylindrical microdetectors |
| title_sort |
Microdosimetry in low energy proton beam at therapeutic-equivalent fluence rate with silicon 3D-cylindrical microdetectors |
| dc.creator.none.fl_str_mv |
Guardiola, Consuelo Bachiller Perea, Diana Prieto Pena, Juan Jiménez Ramos, María del Carmen García López, Francisco Javier Esnault, Cedric Fleta Corral, María Celeste Quirión, David Gómez Rodríguez, Faustino |
| author |
Guardiola, Consuelo |
| author_facet |
Guardiola, Consuelo Bachiller Perea, Diana Prieto Pena, Juan Jiménez Ramos, María del Carmen García López, Francisco Javier Esnault, Cedric Fleta Corral, María Celeste Quirión, David Gómez Rodríguez, Faustino |
| author_role |
author |
| author2 |
Bachiller Perea, Diana Prieto Pena, Juan Jiménez Ramos, María del Carmen García López, Francisco Javier Esnault, Cedric Fleta Corral, María Celeste Quirión, David Gómez Rodríguez, Faustino |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Física Aplicada II Física Atómica, Molecular y Nuclear RNM138: Física Nuclear Aplicada MICIN |
| dc.subject.none.fl_str_mv |
Microdosimetry Proton therapy Silicon 3D microdetectors |
| topic |
Microdosimetry Proton therapy Silicon 3D microdetectors |
| description |
In this work we show the first microdosimetry measurements on a low energy proton beam with therapeutic-equivalent fluence rates by using the second generation of 3D-cylindrical microdetectors. The sensors belong to an improved version of a novel silicon-based 3D-microdetector design with electrodes etched inside silicon, which were manufactured at the National Microelectronics Centre (IMB-CNM, CSIC) in Spain. A new microtechnology has been employed using quasi-toroid electrodes of 25μm diameter and a depth of 20μm within the silicon bulk, resulting in a well-defined cylindrical radiation sensitive volume. These detectors were tested at the 18 MeV proton beamline of the cyclotron at the National Accelerator Centre (CNA, Spain). They were assembled into an in-house low-noise readout electronics to assess their performance at a therapeutic-equivalent fluence rate. Microdosimetry spectra of lineal energy were recorded at several proton energies starting from 18 MeV by adding 50μm thick tungsten foils gradually at the exit-window of the cyclotron external beamline, which corresponds to different depths along the Bragg curve. The experimentalyF¯values in silicon cover from (5.7 ± 0.9) to (8.5 ± 0.4) keV μm-1in the entrance to (27.4 ± 2.3) keV μm-1in the distal edge. Pulse height energy spectra were crosschecked with Monte Carlo simulations and an excellent agreement was obtained. This work demonstrates the capability of the second generation 3D-microdetectors to assess accurate microdosimetric distributions at fluence rates as high as those used in clinical centers in proton therapy. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/11441/135703 https://doi.org/10.1088/1361-6560/abf811 |
| url |
https://hdl.handle.net/11441/135703 https://doi.org/10.1088/1361-6560/abf811 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Physics in Medicine & Biology, 66 (11(114001)) RTI2018-098117-B-C2 https://iopscience.iop.org/article/10.1088/1361-6560/abf811/pdf |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
IOP Publishing |
| publisher.none.fl_str_mv |
IOP Publishing |
| dc.source.none.fl_str_mv |
reponame:idUS. Depósito de Investigación de la Universidad de Sevilla instname:Universidad de Sevilla (US) |
| instname_str |
Universidad de Sevilla (US) |
| reponame_str |
idUS. Depósito de Investigación de la Universidad de Sevilla |
| collection |
idUS. Depósito de Investigación de la Universidad de Sevilla |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869406100273496064 |
| score |
15.300724 |