Gestational exercise and intergenerational inheritance. Metabolic and functional outcomes in rat liver and skeletal muscle

Programa de Doctorat en Biomedicina

Detalles Bibliográficos
Autor: Beleza, Jorge
Tipo de recurso: tesis doctoral
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:CBUC, CESCA
Repositorio:TDR. Tesis Doctorales en Red
OAI Identifier:oai:www.tdx.cat:10803/674461
Acceso en línea:http://hdl.handle.net/10803/674461
Access Level:acceso abierto
Palabra clave:Fisiologia de l'exercici
Fisiología del ejercicio
Exercise physiology
Epigenètica
Epigenética
Epigenetics
Múscul estriat
Músculo estriado
Striated muscle
Fetge
Hígado
Liver
Ciències de la Salut
612
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spelling Gestational exercise and intergenerational inheritance. Metabolic and functional outcomes in rat liver and skeletal muscleBeleza, JorgeFisiologia de l'exerciciFisiología del ejercicioExercise physiologyEpigenèticaEpigenéticaEpigeneticsMúscul estriatMúsculo estriadoStriated muscleFetgeHígadoLiverCiències de la Salut612Programa de Doctorat en BiomedicinaMaternal environmental exposure during gestational period may affect offspring risk for chronic diseases. Accordingly, maternal metabolic disturbances induced by high-fat high-sucrose (HFHS) diets can have a negative impact on offspring liver and skeletal muscle (SM) tissue phenotypes. In contrast, gestational exercise (GE) seems to favorably modulate deleterious stimuli induced by HFHS- diet consumption, not only in mothers but also in their offspring. However, the mechanisms associated to intergenerational inheritance of favorable metabolic outcomes in the offspring are far to be understood, as well as the role of epigenetic regulation in the offspring program. In order to contribute to increase the scientific knowledge in this field, the present PhD thesis comprises two literature review publications and three animal-based experimental papers that were developed using a gestational diabetes mellitus (GDM) model. Therefore, the goal was to analyze the potential role of an exercised model that combines voluntary free-running wheel (FRW) with forced endurance exercise, against liver and SM offspring metabolic and functional impairments. Our data revealed that GE counteracted the negative impact of HFHS maternal diet and sedentarism in offspring liver and SM morphology. Moreover, offspring from HFHS exercised mothers exhibited an improvement in liver and SM parameters of mitochondrial biogenesis, oxidative phosphorylation subunits protein content and respiratory capacity, associated to improvements in maximal exercise performance. Additionally, improvements in biomarkers of mitochondrial performance seems to be regulated, at least in part, by the role of miRNAs through epigenetic modifications inhered by the offspring generation. Ultimately, these findings shed light on the importance of maternal lifestyle, specifically the relevance of GE, on the phenotypic programming of the offspring against GDM-associated metabolic impairments and ultimately to an enhanced functional performance. Hopefully, evidence from the present PhD thesis can contribute to encourage mothers to engage in an active lifestyle before and during pregnancy aiming positive outcomes in their offspring.Universitat de BarcelonaMagalhäes, JoséTorrella Guio, Joan RamonTorrella Guio, Joan RamonUniversitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia202220222022info:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/publishedVersion181 p.application/pdfapplication/pdfhttp://hdl.handle.net/10803/674461TDX (Tesis Doctorals en Xarxa)reponame:TDR. Tesis Doctorales en Redinstname:CBUC, CESCAInglésADVERTIMENT. Tots els drets reservats. L'accés als continguts d'aquesta tesi doctoral i la seva utilització ha de respectar els drets de la persona autora. Pot ser utilitzada per a consulta o estudi personal, així com en activitats o materials d'investigació i docència en els termes establerts a l'art. 32 del Text Refós de la Llei de Propietat Intel·lectual (RDL 1/1996). Per altres utilitzacions es requereix l'autorització prèvia i expressa de la persona autora. En qualsevol cas, en la utilització dels seus continguts caldrà indicar de forma clara el nom i cognoms de la persona autora i el títol de la tesi doctoral. No s'autoritza la seva reproducció o altres formes d'explotació efectuades amb finalitats de lucre ni la seva comunicació pública des d'un lloc aliè al servei TDX. Tampoc s'autoritza la presentació del seu contingut en una finestra o marc aliè a TDX (framing). Aquesta reserva de drets afecta tant als continguts de la tesi com als seus resums i índexs.info:eu-repo/semantics/openAccessoai:www.tdx.cat:10803/6744612026-06-14T12:46:07Z
dc.title.none.fl_str_mv Gestational exercise and intergenerational inheritance. Metabolic and functional outcomes in rat liver and skeletal muscle
title Gestational exercise and intergenerational inheritance. Metabolic and functional outcomes in rat liver and skeletal muscle
spellingShingle Gestational exercise and intergenerational inheritance. Metabolic and functional outcomes in rat liver and skeletal muscle
Beleza, Jorge
Fisiologia de l'exercici
Fisiología del ejercicio
Exercise physiology
Epigenètica
Epigenética
Epigenetics
Múscul estriat
Músculo estriado
Striated muscle
Fetge
Hígado
Liver
Ciències de la Salut
612
title_short Gestational exercise and intergenerational inheritance. Metabolic and functional outcomes in rat liver and skeletal muscle
title_full Gestational exercise and intergenerational inheritance. Metabolic and functional outcomes in rat liver and skeletal muscle
title_fullStr Gestational exercise and intergenerational inheritance. Metabolic and functional outcomes in rat liver and skeletal muscle
title_full_unstemmed Gestational exercise and intergenerational inheritance. Metabolic and functional outcomes in rat liver and skeletal muscle
title_sort Gestational exercise and intergenerational inheritance. Metabolic and functional outcomes in rat liver and skeletal muscle
dc.creator.none.fl_str_mv Beleza, Jorge
author Beleza, Jorge
author_facet Beleza, Jorge
author_role author
dc.contributor.none.fl_str_mv Magalhäes, José
Torrella Guio, Joan Ramon
Torrella Guio, Joan Ramon
Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia
dc.subject.none.fl_str_mv Fisiologia de l'exercici
Fisiología del ejercicio
Exercise physiology
Epigenètica
Epigenética
Epigenetics
Múscul estriat
Músculo estriado
Striated muscle
Fetge
Hígado
Liver
Ciències de la Salut
612
topic Fisiologia de l'exercici
Fisiología del ejercicio
Exercise physiology
Epigenètica
Epigenética
Epigenetics
Múscul estriat
Músculo estriado
Striated muscle
Fetge
Hígado
Liver
Ciències de la Salut
612
description Programa de Doctorat en Biomedicina
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/doctoralThesis
info:eu-repo/semantics/publishedVersion
format doctoralThesis
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10803/674461
url http://hdl.handle.net/10803/674461
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 181 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Universitat de Barcelona
publisher.none.fl_str_mv Universitat de Barcelona
dc.source.none.fl_str_mv TDX (Tesis Doctorals en Xarxa)
reponame:TDR. Tesis Doctorales en Red
instname:CBUC, CESCA
instname_str CBUC, CESCA
reponame_str TDR. Tesis Doctorales en Red
collection TDR. Tesis Doctorales en Red
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869406092131303424
score 15,300724

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