Reduction of Spasticity With Repetitive Transcranial Magnetic Stimulation in Patients With Spinal Cord Injury

Objective. Spasticity with increased tone and spasms is frequent in patients after spinal cord injury (SCI). Damage to descending corticospinal pathways that normally exert spinal segmental control is thought to play an important causal role in spasticity. The authors examined whether the modulation...

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Autores: Kumru, Hatice, Murillo, Narda, Vidal Sanso, Joan, Valls Sole, Josep, Edwards, Dylan, Pelayo, Raúl, Valero Cabre, Antoni, Tormos Muñoz, José María, Pascual Leone, Álvaro
Tipo de recurso: artículo
Fecha de publicación:2010
País:España
Institución:Universidad Católica de Valencia San Vicente Mártir
Repositorio:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
Idioma:inglés
OAI Identifier:oai:riucv.ucv.es:20.500.12466/3320
Acceso en línea:http://hdl.handle.net/20.500.12466/3320
Access Level:acceso abierto
Palabra clave:Spasticity
Repetitive TMS
Spinal cord injury
Neurophysiological examination
2411.11 Neurofisiología
2490 Neurociencias
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spelling Reduction of Spasticity With Repetitive Transcranial Magnetic Stimulation in Patients With Spinal Cord InjuryKumru, HaticeMurillo, NardaVidal Sanso, JoanValls Sole, JosepEdwards, DylanPelayo, RaúlValero Cabre, AntoniTormos Muñoz, José MaríaPascual Leone, ÁlvaroSpasticityRepetitive TMSSpinal cord injuryNeurophysiological examination2411.11 Neurofisiología2490 NeurocienciasObjective. Spasticity with increased tone and spasms is frequent in patients after spinal cord injury (SCI). Damage to descending corticospinal pathways that normally exert spinal segmental control is thought to play an important causal role in spasticity. The authors examined whether the modulation of excitability of the primary motor cortex with highfrequency repetitive transcranial magnetic stimulation (rTMS) could modify lower limb spasticity in patients with incomplete SCI. Methods. Patients were assessed by the Modified Ashworth Scale, Visual Analogue Scale, and the Spinal Cord Injury Spasticity Evaluation Tool (SCI-SET) and neurophysiologically with measures of corticospinal and segmental excitability by the Hmax/Mmax, T reflex, and withdrawal reflex. Fifteen patients received 5 days of daily sessions of active (n = 14) or sham (n = 7) rTMS to the leg motor area (20 trains of 40 pulses at 20 Hz and an intensity of 90% of resting motor threshold for the biceps brachii muscle). Result. A significant clinical improvement in lower limb spasticity was observed in patients following active rTMS but not after sham stimulation. This improvement lasted for at least 1 week following the intervention. Neurophysiological studies did not change. Conclusions. High-frequency rTMS over the leg motor area can improve aspects of spasticity in patients with incomplete SCI.20232023-12-1820102010-01-0620102010-01-06journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12466/3320reponame:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártirinstname:Universidad Católica de Valencia San Vicente MártirInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:riucv.ucv.es:20.500.12466/33202026-06-19T08:32:07Z
dc.title.none.fl_str_mv Reduction of Spasticity With Repetitive Transcranial Magnetic Stimulation in Patients With Spinal Cord Injury
title Reduction of Spasticity With Repetitive Transcranial Magnetic Stimulation in Patients With Spinal Cord Injury
spellingShingle Reduction of Spasticity With Repetitive Transcranial Magnetic Stimulation in Patients With Spinal Cord Injury
Kumru, Hatice
Spasticity
Repetitive TMS
Spinal cord injury
Neurophysiological examination
2411.11 Neurofisiología
2490 Neurociencias
title_short Reduction of Spasticity With Repetitive Transcranial Magnetic Stimulation in Patients With Spinal Cord Injury
title_full Reduction of Spasticity With Repetitive Transcranial Magnetic Stimulation in Patients With Spinal Cord Injury
title_fullStr Reduction of Spasticity With Repetitive Transcranial Magnetic Stimulation in Patients With Spinal Cord Injury
title_full_unstemmed Reduction of Spasticity With Repetitive Transcranial Magnetic Stimulation in Patients With Spinal Cord Injury
title_sort Reduction of Spasticity With Repetitive Transcranial Magnetic Stimulation in Patients With Spinal Cord Injury
dc.creator.none.fl_str_mv Kumru, Hatice
Murillo, Narda
Vidal Sanso, Joan
Valls Sole, Josep
Edwards, Dylan
Pelayo, Raúl
Valero Cabre, Antoni
Tormos Muñoz, José María
Pascual Leone, Álvaro
author Kumru, Hatice
author_facet Kumru, Hatice
Murillo, Narda
Vidal Sanso, Joan
Valls Sole, Josep
Edwards, Dylan
Pelayo, Raúl
Valero Cabre, Antoni
Tormos Muñoz, José María
Pascual Leone, Álvaro
author_role author
author2 Murillo, Narda
Vidal Sanso, Joan
Valls Sole, Josep
Edwards, Dylan
Pelayo, Raúl
Valero Cabre, Antoni
Tormos Muñoz, José María
Pascual Leone, Álvaro
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Spasticity
Repetitive TMS
Spinal cord injury
Neurophysiological examination
2411.11 Neurofisiología
2490 Neurociencias
topic Spasticity
Repetitive TMS
Spinal cord injury
Neurophysiological examination
2411.11 Neurofisiología
2490 Neurociencias
description Objective. Spasticity with increased tone and spasms is frequent in patients after spinal cord injury (SCI). Damage to descending corticospinal pathways that normally exert spinal segmental control is thought to play an important causal role in spasticity. The authors examined whether the modulation of excitability of the primary motor cortex with highfrequency repetitive transcranial magnetic stimulation (rTMS) could modify lower limb spasticity in patients with incomplete SCI. Methods. Patients were assessed by the Modified Ashworth Scale, Visual Analogue Scale, and the Spinal Cord Injury Spasticity Evaluation Tool (SCI-SET) and neurophysiologically with measures of corticospinal and segmental excitability by the Hmax/Mmax, T reflex, and withdrawal reflex. Fifteen patients received 5 days of daily sessions of active (n = 14) or sham (n = 7) rTMS to the leg motor area (20 trains of 40 pulses at 20 Hz and an intensity of 90% of resting motor threshold for the biceps brachii muscle). Result. A significant clinical improvement in lower limb spasticity was observed in patients following active rTMS but not after sham stimulation. This improvement lasted for at least 1 week following the intervention. Neurophysiological studies did not change. Conclusions. High-frequency rTMS over the leg motor area can improve aspects of spasticity in patients with incomplete SCI.
publishDate 2010
dc.date.none.fl_str_mv 2010
2010-01-06
2010
2010-01-06
2023
2023-12-18
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12466/3320
url http://hdl.handle.net/20.500.12466/3320
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial 4.0 Internacional
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial 4.0 Internacional
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
instname:Universidad Católica de Valencia San Vicente Mártir
instname_str Universidad Católica de Valencia San Vicente Mártir
reponame_str RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
collection RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300724

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