Advances in precision medicine in recurrent reproductive failure of immunological cause
Recurrent reproductive failures include two distinct entities: recurrent pregnancy losses (RPL) and repeated implantation failures (RIF). Both conditions share some etiologies, such as anatomical, genetic, immunological and endocrine causes, among others. However, the origin of many cases remains un...
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| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/129903 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/129903 |
| Access Level: | acceso abierto |
| Palabra clave: | 618.39(043.2) Aborto espontáneo Miscarriage Ginecología y obstetricia 3201.08 Ginecología |
| Sumario: | Recurrent reproductive failures include two distinct entities: recurrent pregnancy losses (RPL) and repeated implantation failures (RIF). Both conditions share some etiologies, such as anatomical, genetic, immunological and endocrine causes, among others. However, the origin of many cases remains unknown, with up to 50% of RPL patients having an unexplained cause. In recent years, the immune system's role has become crucial in explaining many previously unexplained cases. The role of NK cells in these pathologies, both in terms of number and function, has been extensively studied over the past 20 years. Similarly, monocytes, which are also essential for pregnancy development, have gained more attention, although their study has mainly focused on their role in other conditions, especially preeclampsia. Initially, it was believed that a pro-inflammatory state during pregnancy could be harmful to its proper development... |
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