Hair cell toxicology: With the help of a little fish

Hearing or balance loss are disabling conditions that have a serious impact in those suffering them, especially when they appear in children. Their ultimate cause is frequently the loss of function of mechanosensory hair cells in the inner ear. Hair cells can be damaged by environmental insults, lik...

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Detalles Bibliográficos
Autores: Barrallo Gimeno, Alejandro, Llorens i Baucells, Jordi
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/192528
Acceso en línea:https://hdl.handle.net/2445/192528
Access Level:acceso abierto
Palabra clave:Peix zebra
Cisplatí
Cèl·lules acústiques
Antibiòtics
Zebra danio
Cisplatin
Hair cells
Antibiotics
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spelling Hair cell toxicology: With the help of a little fishBarrallo Gimeno, AlejandroLlorens i Baucells, JordiPeix zebraCisplatíCèl·lules acústiquesAntibiòticsZebra danioCisplatinHair cellsAntibioticsHearing or balance loss are disabling conditions that have a serious impact in those suffering them, especially when they appear in children. Their ultimate cause is frequently the loss of function of mechanosensory hair cells in the inner ear. Hair cells can be damaged by environmental insults, like noise or chemical agents, known as ototoxins. Two of the most common ototoxins are life-saving medications: cisplatin against solid tumors, and aminoglycoside antibiotics to treat infections. However, due to their localization inside the temporal bone, hair cells are difficult to study in mammals. As an alternative animal model, zebrafish larvae have hair cells similar to those in mammals, some of which are located in a fish specific organ on the surface of the skin, the lateral line. This makes them easy to observe in vivo and readily accessible for ototoxins or otoprotective substances. These features have made possible advances in the study of the mechanisms mediating ototoxicity or identifying new potential ototoxins. Most importantly, the small size of the zebrafish larvae has allowed screening thousands of molecules searching for otoprotective agents in a scale that would be highly impractical in rodent models. The positive hits found can then start the long road to reach clinical settings to prevent hearing or balance loss.Frontiers Media SA2023202320222023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/192528Articles publicats en revistes (Ciències Fisiològiques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3389/fcell.2022.1085225Frontiers in Cell and Developmental Biology, 2022, vol. 10https://doi.org/10.3389/fcell.2022.1085225cc by (c) Barrallo-Gimeno, Alejandro et al., 2022http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1925282026-05-29T05:05:01Z
dc.title.none.fl_str_mv Hair cell toxicology: With the help of a little fish
title Hair cell toxicology: With the help of a little fish
spellingShingle Hair cell toxicology: With the help of a little fish
Barrallo Gimeno, Alejandro
Peix zebra
Cisplatí
Cèl·lules acústiques
Antibiòtics
Zebra danio
Cisplatin
Hair cells
Antibiotics
title_short Hair cell toxicology: With the help of a little fish
title_full Hair cell toxicology: With the help of a little fish
title_fullStr Hair cell toxicology: With the help of a little fish
title_full_unstemmed Hair cell toxicology: With the help of a little fish
title_sort Hair cell toxicology: With the help of a little fish
dc.creator.none.fl_str_mv Barrallo Gimeno, Alejandro
Llorens i Baucells, Jordi
author Barrallo Gimeno, Alejandro
author_facet Barrallo Gimeno, Alejandro
Llorens i Baucells, Jordi
author_role author
author2 Llorens i Baucells, Jordi
author2_role author
dc.subject.none.fl_str_mv Peix zebra
Cisplatí
Cèl·lules acústiques
Antibiòtics
Zebra danio
Cisplatin
Hair cells
Antibiotics
topic Peix zebra
Cisplatí
Cèl·lules acústiques
Antibiòtics
Zebra danio
Cisplatin
Hair cells
Antibiotics
description Hearing or balance loss are disabling conditions that have a serious impact in those suffering them, especially when they appear in children. Their ultimate cause is frequently the loss of function of mechanosensory hair cells in the inner ear. Hair cells can be damaged by environmental insults, like noise or chemical agents, known as ototoxins. Two of the most common ototoxins are life-saving medications: cisplatin against solid tumors, and aminoglycoside antibiotics to treat infections. However, due to their localization inside the temporal bone, hair cells are difficult to study in mammals. As an alternative animal model, zebrafish larvae have hair cells similar to those in mammals, some of which are located in a fish specific organ on the surface of the skin, the lateral line. This makes them easy to observe in vivo and readily accessible for ototoxins or otoprotective substances. These features have made possible advances in the study of the mechanisms mediating ototoxicity or identifying new potential ototoxins. Most importantly, the small size of the zebrafish larvae has allowed screening thousands of molecules searching for otoprotective agents in a scale that would be highly impractical in rodent models. The positive hits found can then start the long road to reach clinical settings to prevent hearing or balance loss.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/192528
url https://hdl.handle.net/2445/192528
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fcell.2022.1085225
Frontiers in Cell and Developmental Biology, 2022, vol. 10
https://doi.org/10.3389/fcell.2022.1085225
dc.rights.none.fl_str_mv cc by (c) Barrallo-Gimeno, Alejandro et al., 2022
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Barrallo-Gimeno, Alejandro et al., 2022
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media SA
publisher.none.fl_str_mv Frontiers Media SA
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Fisiològiques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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