Senescence in tumours: evidence from mice and humans

The importance of cellular senescence, which is a stress response that stably blocks proliferation, is increasingly being recognized. Senescence is prevalent in pre-malignant tumours, and progression to malignancy requires evading senescence. Malignant tumours, however, may still undergo senescence...

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Detalles Bibliográficos
Autores: Collado, Manuel, Serrano, Manuel
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2010
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/345057
Acceso en línea:http://hdl.handle.net/10261/345057
Access Level:acceso abierto
Palabra clave:Oncogenes
Senescence
Tumour suppressors
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spelling Senescence in tumours: evidence from mice and humansCollado, ManuelSerrano, ManuelOncogenesSenescenceTumour suppressorsThe importance of cellular senescence, which is a stress response that stably blocks proliferation, is increasingly being recognized. Senescence is prevalent in pre-malignant tumours, and progression to malignancy requires evading senescence. Malignant tumours, however, may still undergo senescence owing to interventions that restore tumour suppressor function or inactivate oncogenes. Senescent tumour cells can be cleared by immune cells, which may result in efficient tumour regression. Standard chemotherapy also has the potential to induce senescence, which may partly underlie its therapeutic activity. Although these concepts are well supported in mouse models, translating them to clinical oncology remains a challenge.Work in the authors' laboratory is funded by the Spanish National Cancer Research Centre, the Spanish Ministry of Science, the Regional Government of Madrid, the European Union (PROTEOMAGE), the European Research Council and the Marcelino Botin Foundation.Peer reviewedMacmillan PublishersCentro Nacional de Investigaciones Oncológicas (España)Ministerio de Ciencia e Innovación (España)Comunidad de MadridEuropean Research Council202420242010info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttp://hdl.handle.net/10261/345057reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1038/nrc2772Noinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3450572026-05-22T06:33:51Z
dc.title.none.fl_str_mv Senescence in tumours: evidence from mice and humans
title Senescence in tumours: evidence from mice and humans
spellingShingle Senescence in tumours: evidence from mice and humans
Collado, Manuel
Oncogenes
Senescence
Tumour suppressors
title_short Senescence in tumours: evidence from mice and humans
title_full Senescence in tumours: evidence from mice and humans
title_fullStr Senescence in tumours: evidence from mice and humans
title_full_unstemmed Senescence in tumours: evidence from mice and humans
title_sort Senescence in tumours: evidence from mice and humans
dc.creator.none.fl_str_mv Collado, Manuel
Serrano, Manuel
author Collado, Manuel
author_facet Collado, Manuel
Serrano, Manuel
author_role author
author2 Serrano, Manuel
author2_role author
dc.contributor.none.fl_str_mv Centro Nacional de Investigaciones Oncológicas (España)
Ministerio de Ciencia e Innovación (España)
Comunidad de Madrid
European Research Council
dc.subject.none.fl_str_mv Oncogenes
Senescence
Tumour suppressors
topic Oncogenes
Senescence
Tumour suppressors
description The importance of cellular senescence, which is a stress response that stably blocks proliferation, is increasingly being recognized. Senescence is prevalent in pre-malignant tumours, and progression to malignancy requires evading senescence. Malignant tumours, however, may still undergo senescence owing to interventions that restore tumour suppressor function or inactivate oncogenes. Senescent tumour cells can be cleared by immune cells, which may result in efficient tumour regression. Standard chemotherapy also has the potential to induce senescence, which may partly underlie its therapeutic activity. Although these concepts are well supported in mouse models, translating them to clinical oncology remains a challenge.
publishDate 2010
dc.date.none.fl_str_mv 2010
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/345057
url http://hdl.handle.net/10261/345057
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1038/nrc2772
No
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Macmillan Publishers
publisher.none.fl_str_mv Macmillan Publishers
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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