Glycolysis - a key player in the inflammatory response

The inflammatory response involves the activation of several cell types to fight insults caused by a plethora of agents, and to maintain the tissue homoeostasis. On the one hand, cells involved in the pro-inflammatory response, such as inflammatory M1 macrophages, Th1 and Th17 lympho cytes or activa...

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Detalhes bibliográficos
Autores: Soto Heredero, Gonzalo, Gómez de las Heras, Manuel M., Gabandé Rodríguez, Enrique, Oller, Jorge, Mittelbrunn, María
Formato: artículo
Fecha de publicación:2020
País:España
Recursos:Universidad Alfonso X el Sabio
Repositorio:Repositorio Institucional de la Universidad Alfonso X el Sabio
Idioma:inglés
OAI Identifier:oai:archive.uax.com:20.500.12080/45176
Acesso em linha:https://hdl.handle.net/20.500.12080/45176
Access Level:acceso abierto
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spelling Glycolysis - a key player in the inflammatory responseSoto Heredero, GonzaloGómez de las Heras, Manuel M.Gabandé Rodríguez, EnriqueOller, JorgeMittelbrunn, MaríaThe inflammatory response involves the activation of several cell types to fight insults caused by a plethora of agents, and to maintain the tissue homoeostasis. On the one hand, cells involved in the pro-inflammatory response, such as inflammatory M1 macrophages, Th1 and Th17 lympho cytes or activated microglia, must rapidly provide energy to fuel inflamma tion, which is essentially accomplished by glycolysis and high lactate production. On the other hand, regulatory T cells or M2 macrophages, which are involved in immune regulation and resolution of inflammation, preferentially use fatty acid oxidation through the TCA cycle as a main source for energy production. Here, we discuss the impact of glycolytic metabolism at the different steps of the inflammatory response. Finally, we review a wide variety of molecular mechanisms which could explain the relationship between glycolytic metabolites and the pro-inflammatory phe notype, including signalling events, epigenetic remodelling, post-transcrip tional regulation and post-translational modifications. Inflammatory processes are a common feature of many age-associated diseases, such as cardiovascular and neurodegenerative disorders. The finding that immuno metabolism could be a master regulator of inflammation broadens the ave nue for treating inflammation-related pathologies through the manipulation of the vascular and immune cell metabolism.UAX Archive20202020-01-0120202020-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.12080/45176reponame:Repositorio Institucional de la Universidad Alfonso X el Sabioinstname:Universidad Alfonso X el SabioInglésengopen accesshttp://purl.org/coar/access_right/c_abf2CC-BYhttp://creativecommons.org/licenses/by/4.0/deed.esinfo:eu-repo/semantics/openAccessoai:archive.uax.com:20.500.12080/451762026-05-28T12:40:21Z
dc.title.none.fl_str_mv Glycolysis - a key player in the inflammatory response
title Glycolysis - a key player in the inflammatory response
spellingShingle Glycolysis - a key player in the inflammatory response
Soto Heredero, Gonzalo
title_short Glycolysis - a key player in the inflammatory response
title_full Glycolysis - a key player in the inflammatory response
title_fullStr Glycolysis - a key player in the inflammatory response
title_full_unstemmed Glycolysis - a key player in the inflammatory response
title_sort Glycolysis - a key player in the inflammatory response
dc.creator.none.fl_str_mv Soto Heredero, Gonzalo
Gómez de las Heras, Manuel M.
Gabandé Rodríguez, Enrique
Oller, Jorge
Mittelbrunn, María
author Soto Heredero, Gonzalo
author_facet Soto Heredero, Gonzalo
Gómez de las Heras, Manuel M.
Gabandé Rodríguez, Enrique
Oller, Jorge
Mittelbrunn, María
author_role author
author2 Gómez de las Heras, Manuel M.
Gabandé Rodríguez, Enrique
Oller, Jorge
Mittelbrunn, María
author2_role author
author
author
author
dc.contributor.none.fl_str_mv UAX Archive
description The inflammatory response involves the activation of several cell types to fight insults caused by a plethora of agents, and to maintain the tissue homoeostasis. On the one hand, cells involved in the pro-inflammatory response, such as inflammatory M1 macrophages, Th1 and Th17 lympho cytes or activated microglia, must rapidly provide energy to fuel inflamma tion, which is essentially accomplished by glycolysis and high lactate production. On the other hand, regulatory T cells or M2 macrophages, which are involved in immune regulation and resolution of inflammation, preferentially use fatty acid oxidation through the TCA cycle as a main source for energy production. Here, we discuss the impact of glycolytic metabolism at the different steps of the inflammatory response. Finally, we review a wide variety of molecular mechanisms which could explain the relationship between glycolytic metabolites and the pro-inflammatory phe notype, including signalling events, epigenetic remodelling, post-transcrip tional regulation and post-translational modifications. Inflammatory processes are a common feature of many age-associated diseases, such as cardiovascular and neurodegenerative disorders. The finding that immuno metabolism could be a master regulator of inflammation broadens the ave nue for treating inflammation-related pathologies through the manipulation of the vascular and immune cell metabolism.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01
2020
2020-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12080/45176
url https://hdl.handle.net/20.500.12080/45176
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
CC-BY
http://creativecommons.org/licenses/by/4.0/deed.es
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
CC-BY
http://creativecommons.org/licenses/by/4.0/deed.es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositorio Institucional de la Universidad Alfonso X el Sabio
instname:Universidad Alfonso X el Sabio
instname_str Universidad Alfonso X el Sabio
reponame_str Repositorio Institucional de la Universidad Alfonso X el Sabio
collection Repositorio Institucional de la Universidad Alfonso X el Sabio
repository.name.fl_str_mv
repository.mail.fl_str_mv
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