Clinical and neurophysiological effects of bilateral repetitive transcranial magnetic stimulation and EEG-guided neurofeedback in Parkinson’s disease: a randomized, four-arm controlled trial.

Romero Muñoz, Juan Pablo; Moreno Verdú, Marcos; Arroyo Ferrer, Aida; Serrano, J. Ignacio; Herreros-Rodríguez, Jaime; García-Caldentey, Juan; Rocon de Lima, Eduardo; Del Castillo, María Dolores

Clinical and neurophysiological effects of bilateral repetitive transcranial magnetic stimulation and EEG-guided neurofeedback in Parkinson’s disease: a randomized, four-arm controlled trial.

Background Repetitive Transcranial Magnetic Stimulation (rTMS) and EEG-guided neurofeedback techniques can reduce motor symptoms in Parkinson’s disease (PD). However, the effects of their combination are unknown. Our objective was to determine the immediate and short-term effects on motor and non-mo...

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Autores:	Romero Muñoz, Juan Pablo, Moreno Verdú, Marcos, Arroyo Ferrer, Aida, Serrano, J. Ignacio, Herreros-Rodríguez, Jaime, García-Caldentey, Juan, Rocon de Lima, Eduardo, Del Castillo, María Dolores
Tipo de recurso:	artículo
Fecha de publicación:	2024
País:	España
Institución:	Universidad Francisco de Vitoria
Repositorio:	DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
Idioma:	inglés
OAI Identifier:	oai:ddfv.ufv.es:10641/5491
Acceso en línea:	https://hdl.handle.net/10641/5491
Access Level:	acceso abierto
Palabra clave:	Parkinson’s disease Non-invasive neuromodulation Repetitive transcranial magnetic stimulation Neurofeedback Motor symptoms

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spelling	Clinical and neurophysiological effects of bilateral repetitive transcranial magnetic stimulation and EEG-guided neurofeedback in Parkinson’s disease: a randomized, four-arm controlled trial.Romero Muñoz, Juan PabloMoreno Verdú, MarcosArroyo Ferrer, AidaSerrano, J. IgnacioHerreros-Rodríguez, JaimeGarcía-Caldentey, JuanRocon de Lima, EduardoDel Castillo, María DoloresParkinson’s diseaseNon-invasive neuromodulationRepetitive transcranial magnetic stimulationNeurofeedbackMotor symptomsBackground Repetitive Transcranial Magnetic Stimulation (rTMS) and EEG-guided neurofeedback techniques can reduce motor symptoms in Parkinson’s disease (PD). However, the effects of their combination are unknown. Our objective was to determine the immediate and short-term effects on motor and non-motor symptoms, and neurophysiological measures, of rTMS and EEG-guided neurofeedback, alone or combined, compared to no intervention, in people with PD. Methods A randomized, single-blinded controlled trial with 4 arms was conducted. Group A received eight bilateral, high-frequency (10 Hz) rTMS sessions over the Primary Motor Cortices; Group B received eight 30-minute EEGguided neurofeedback sessions focused on reducing average bilateral alpha and beta bands; Group C received a combination of A and B; Group D did not receive any therapy. The primary outcome measure was the UPDRS-III at post-intervention and two weeks later. Secondary outcomes were functional mobility, limits of stability, depression, health-related quality-of-life and cortical silent periods. Treatment effects were obtained by longitudinal analysis of covariance mixed-effects models. Results Forty people with PD participated (27 males, age = 63 ± 8.26 years, baseline UPDRS-III = 15.63 ± 6.99 points, H&Y = 1–3). Group C showed the largest effect on motor symptoms, health-related quality-of-life and cortical silent periods, followed by Group A and Group B. Negligible differences between Groups A-C and Group D for functional mobility or limits of stability were found. Conclusions The combination of rTMS and EEG-guided neurofeedback diminished overall motor symptoms and increased quality-of-life, but this was not reflected by changes in functional mobility, postural stability or depression levels.BioMed Central20242024-01-0120242024-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10641/5491reponame:DDFV. Repositorio Institucional de la Universidad Francisco de Vitoriainstname:Universidad Francisco de VitoriaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddfv.ufv.es:10641/54912026-06-11T12:44:57Z
dc.title.none.fl_str_mv	Clinical and neurophysiological effects of bilateral repetitive transcranial magnetic stimulation and EEG-guided neurofeedback in Parkinson’s disease: a randomized, four-arm controlled trial.
title	Clinical and neurophysiological effects of bilateral repetitive transcranial magnetic stimulation and EEG-guided neurofeedback in Parkinson’s disease: a randomized, four-arm controlled trial.
spellingShingle	Clinical and neurophysiological effects of bilateral repetitive transcranial magnetic stimulation and EEG-guided neurofeedback in Parkinson’s disease: a randomized, four-arm controlled trial. Romero Muñoz, Juan Pablo Parkinson’s disease Non-invasive neuromodulation Repetitive transcranial magnetic stimulation Neurofeedback Motor symptoms
title_short	Clinical and neurophysiological effects of bilateral repetitive transcranial magnetic stimulation and EEG-guided neurofeedback in Parkinson’s disease: a randomized, four-arm controlled trial.
title_full	Clinical and neurophysiological effects of bilateral repetitive transcranial magnetic stimulation and EEG-guided neurofeedback in Parkinson’s disease: a randomized, four-arm controlled trial.
title_fullStr	Clinical and neurophysiological effects of bilateral repetitive transcranial magnetic stimulation and EEG-guided neurofeedback in Parkinson’s disease: a randomized, four-arm controlled trial.
title_full_unstemmed	Clinical and neurophysiological effects of bilateral repetitive transcranial magnetic stimulation and EEG-guided neurofeedback in Parkinson’s disease: a randomized, four-arm controlled trial.
title_sort	Clinical and neurophysiological effects of bilateral repetitive transcranial magnetic stimulation and EEG-guided neurofeedback in Parkinson’s disease: a randomized, four-arm controlled trial.
dc.creator.none.fl_str_mv	Romero Muñoz, Juan Pablo Moreno Verdú, Marcos Arroyo Ferrer, Aida Serrano, J. Ignacio Herreros-Rodríguez, Jaime García-Caldentey, Juan Rocon de Lima, Eduardo Del Castillo, María Dolores
author	Romero Muñoz, Juan Pablo
author_facet	Romero Muñoz, Juan Pablo Moreno Verdú, Marcos Arroyo Ferrer, Aida Serrano, J. Ignacio Herreros-Rodríguez, Jaime García-Caldentey, Juan Rocon de Lima, Eduardo Del Castillo, María Dolores
author_role	author
author2	Moreno Verdú, Marcos Arroyo Ferrer, Aida Serrano, J. Ignacio Herreros-Rodríguez, Jaime García-Caldentey, Juan Rocon de Lima, Eduardo Del Castillo, María Dolores
author2_role	author author author author author author author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv	Parkinson’s disease Non-invasive neuromodulation Repetitive transcranial magnetic stimulation Neurofeedback Motor symptoms
topic	Parkinson’s disease Non-invasive neuromodulation Repetitive transcranial magnetic stimulation Neurofeedback Motor symptoms
description	Background Repetitive Transcranial Magnetic Stimulation (rTMS) and EEG-guided neurofeedback techniques can reduce motor symptoms in Parkinson’s disease (PD). However, the effects of their combination are unknown. Our objective was to determine the immediate and short-term effects on motor and non-motor symptoms, and neurophysiological measures, of rTMS and EEG-guided neurofeedback, alone or combined, compared to no intervention, in people with PD. Methods A randomized, single-blinded controlled trial with 4 arms was conducted. Group A received eight bilateral, high-frequency (10 Hz) rTMS sessions over the Primary Motor Cortices; Group B received eight 30-minute EEGguided neurofeedback sessions focused on reducing average bilateral alpha and beta bands; Group C received a combination of A and B; Group D did not receive any therapy. The primary outcome measure was the UPDRS-III at post-intervention and two weeks later. Secondary outcomes were functional mobility, limits of stability, depression, health-related quality-of-life and cortical silent periods. Treatment effects were obtained by longitudinal analysis of covariance mixed-effects models. Results Forty people with PD participated (27 males, age = 63 ± 8.26 years, baseline UPDRS-III = 15.63 ± 6.99 points, H&Y = 1–3). Group C showed the largest effect on motor symptoms, health-related quality-of-life and cortical silent periods, followed by Group A and Group B. Negligible differences between Groups A-C and Group D for functional mobility or limits of stability were found. Conclusions The combination of rTMS and EEG-guided neurofeedback diminished overall motor symptoms and increased quality-of-life, but this was not reflected by changes in functional mobility, postural stability or depression levels.
publishDate	2024
dc.date.none.fl_str_mv	2024 2024-01-01 2024 2024-01-01
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10641/5491
url	https://hdl.handle.net/10641/5491
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	BioMed Central
publisher.none.fl_str_mv	BioMed Central
dc.source.none.fl_str_mv	reponame:DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria instname:Universidad Francisco de Vitoria
instname_str	Universidad Francisco de Vitoria
reponame_str	DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
collection	DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Clinical and neurophysiological effects of bilateral repetitive transcranial magnetic stimulation and EEG-guided neurofeedback in Parkinson’s disease: a randomized, four-arm controlled trial.

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