Variation in Nicotine Metabolization According to Biological Factors and Type of Nicotine Consumer

This study aims to describe the nicotine metabolite ratio among tobacco smokers and electronic cigarette (e-cigarette) users and nonusers. We analyzed pooled data from a longitudinal and a cross-sectional study of the adult population from the city of Barcelona. The final sample included information...

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Autores: Pérez Martín, Hipólito, Lidón Moyano, Cristina, González Marrón, Adrián, Fu Balboa, Marcela, Pérez Ortuño, Raúl, Ballbè i Gibernau, Montse, Martín Sánchez, Juan Carlos, Pascual, José Antonio, Fernández Muñoz, Esteve, Martínez Sánchez, Jose M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/192811
Acceso en línea:https://hdl.handle.net/2445/192811
Access Level:acceso abierto
Palabra clave:Nicotina
Metabolisme
Cigarretes electròniques
Hàbit de fumar
Nicotine
Metabolism
Electronic cigarettes
Smoking
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spelling Variation in Nicotine Metabolization According to Biological Factors and Type of Nicotine ConsumerPérez Martín, HipólitoLidón Moyano, CristinaGonzález Marrón, AdriánFu Balboa, MarcelaPérez Ortuño, RaúlBallbè i Gibernau, MontseMartín Sánchez, Juan CarlosPascual, José AntonioFernández Muñoz, EsteveMartínez Sánchez, Jose M.NicotinaMetabolismeCigarretes electròniquesHàbit de fumarNicotineMetabolismElectronic cigarettesSmokingThis study aims to describe the nicotine metabolite ratio among tobacco smokers and electronic cigarette (e-cigarette) users and nonusers. We analyzed pooled data from a longitudinal and a cross-sectional study of the adult population from the city of Barcelona. The final sample included information on 166 smokers, 164 e-cigarettes users with nicotine, 41 e-cigarette users without nicotine, 95 dual users (users of both products), and 508 nonusers. We used log-linear models to control for the potential confounding effect of the daily number of cigarettes smoked. Salivary nicotine metabolic rate assessment included the rate of nicotine metabolism (cotinine/nicotine) and the nicotine metabolite ratio (trans-3′-hydroxycotinine/cotinine). Exclusive users of e-cigarette without nicotine have the lowest rate of nicotine metabolism (Geometric mean: 0.08, p-values < 0.001) while cigarette smokers have the highest (Geometric mean: 2.08, p-values < 0.001). Nonusers have lower nicotine metabolic rate than cigarette smokers (Geometric means: 0.23 vs. 0.18, p-value < 0.05). Younger individuals (18–44 years) have a higher rate of nicotine metabolism than older individuals (45–64 years and 65–89) (Geometric means: 0.53 vs. 0.42 and 0.31, respectively, p-values < 0.01) and individuals with lower body mass index (21–25 kg/m2) have a higher rate of nicotine metabolism than the rest (26–30 kg/m2 and 31–60 kg/m2) (Geometric means: 0.52 vs. 0.35 and 0.36, respectively-values < 0.01). Nicotine metabolic rates are useful biomarkers when reporting smoking status and biological differences between individuals.MDPI AG2023202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfhttps://hdl.handle.net/2445/192811Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/healthcare11020179Healthcare, 2023, vol. 11, num. 2, p. 179https://doi.org/10.3390/healthcare11020179cc by (c) Pérez Martín, Hipólito et al., 2023http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1928112026-05-29T05:05:01Z
dc.title.none.fl_str_mv Variation in Nicotine Metabolization According to Biological Factors and Type of Nicotine Consumer
title Variation in Nicotine Metabolization According to Biological Factors and Type of Nicotine Consumer
spellingShingle Variation in Nicotine Metabolization According to Biological Factors and Type of Nicotine Consumer
Pérez Martín, Hipólito
Nicotina
Metabolisme
Cigarretes electròniques
Hàbit de fumar
Nicotine
Metabolism
Electronic cigarettes
Smoking
title_short Variation in Nicotine Metabolization According to Biological Factors and Type of Nicotine Consumer
title_full Variation in Nicotine Metabolization According to Biological Factors and Type of Nicotine Consumer
title_fullStr Variation in Nicotine Metabolization According to Biological Factors and Type of Nicotine Consumer
title_full_unstemmed Variation in Nicotine Metabolization According to Biological Factors and Type of Nicotine Consumer
title_sort Variation in Nicotine Metabolization According to Biological Factors and Type of Nicotine Consumer
dc.creator.none.fl_str_mv Pérez Martín, Hipólito
Lidón Moyano, Cristina
González Marrón, Adrián
Fu Balboa, Marcela
Pérez Ortuño, Raúl
Ballbè i Gibernau, Montse
Martín Sánchez, Juan Carlos
Pascual, José Antonio
Fernández Muñoz, Esteve
Martínez Sánchez, Jose M.
author Pérez Martín, Hipólito
author_facet Pérez Martín, Hipólito
Lidón Moyano, Cristina
González Marrón, Adrián
Fu Balboa, Marcela
Pérez Ortuño, Raúl
Ballbè i Gibernau, Montse
Martín Sánchez, Juan Carlos
Pascual, José Antonio
Fernández Muñoz, Esteve
Martínez Sánchez, Jose M.
author_role author
author2 Lidón Moyano, Cristina
González Marrón, Adrián
Fu Balboa, Marcela
Pérez Ortuño, Raúl
Ballbè i Gibernau, Montse
Martín Sánchez, Juan Carlos
Pascual, José Antonio
Fernández Muñoz, Esteve
Martínez Sánchez, Jose M.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Nicotina
Metabolisme
Cigarretes electròniques
Hàbit de fumar
Nicotine
Metabolism
Electronic cigarettes
Smoking
topic Nicotina
Metabolisme
Cigarretes electròniques
Hàbit de fumar
Nicotine
Metabolism
Electronic cigarettes
Smoking
description This study aims to describe the nicotine metabolite ratio among tobacco smokers and electronic cigarette (e-cigarette) users and nonusers. We analyzed pooled data from a longitudinal and a cross-sectional study of the adult population from the city of Barcelona. The final sample included information on 166 smokers, 164 e-cigarettes users with nicotine, 41 e-cigarette users without nicotine, 95 dual users (users of both products), and 508 nonusers. We used log-linear models to control for the potential confounding effect of the daily number of cigarettes smoked. Salivary nicotine metabolic rate assessment included the rate of nicotine metabolism (cotinine/nicotine) and the nicotine metabolite ratio (trans-3′-hydroxycotinine/cotinine). Exclusive users of e-cigarette without nicotine have the lowest rate of nicotine metabolism (Geometric mean: 0.08, p-values < 0.001) while cigarette smokers have the highest (Geometric mean: 2.08, p-values < 0.001). Nonusers have lower nicotine metabolic rate than cigarette smokers (Geometric means: 0.23 vs. 0.18, p-value < 0.05). Younger individuals (18–44 years) have a higher rate of nicotine metabolism than older individuals (45–64 years and 65–89) (Geometric means: 0.53 vs. 0.42 and 0.31, respectively, p-values < 0.01) and individuals with lower body mass index (21–25 kg/m2) have a higher rate of nicotine metabolism than the rest (26–30 kg/m2 and 31–60 kg/m2) (Geometric means: 0.52 vs. 0.35 and 0.36, respectively-values < 0.01). Nicotine metabolic rates are useful biomarkers when reporting smoking status and biological differences between individuals.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/192811
url https://hdl.handle.net/2445/192811
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/healthcare11020179
Healthcare, 2023, vol. 11, num. 2, p. 179
https://doi.org/10.3390/healthcare11020179
dc.rights.none.fl_str_mv cc by (c) Pérez Martín, Hipólito et al., 2023
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Pérez Martín, Hipólito et al., 2023
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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