Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis

10 páginas, 8 figuras. Material complementario del artículo esta disponible en http://dev.biologists.org/cgi/content/full/132/13/3093/DC1

Detalles Bibliográficos
Autores: Merabet, Samir, Castelli-Gair Hombría, James, Hu, Nan, Pradel, Jacques, Graba, Yacine
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2005
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/41257
Acceso en línea:http://hdl.handle.net/10261/41257
Access Level:acceso abierto
Palabra clave:Hox
Signalling
Organogenesis
Drosophila
id ES_3725e2b1ecb3121e41d782eaaebc8a8d
oai_identifier_str oai:digital.csic.es:10261/41257
network_acronym_str ES
network_name_str España
repository_id_str
spelling Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesisMerabet, SamirCastelli-Gair Hombría, JamesHu, NanPradel, JacquesGraba, YacineHoxSignallingOrganogenesisDrosophila10 páginas, 8 figuras. Material complementario del artículo esta disponible en http://dev.biologists.org/cgi/content/full/132/13/3093/DC1Hox proteins provide axial positional information and control segment morphology in development and evolution. Yet how they specify morphological traits that confer segment identity and how axial positional information interferes with intrasegmental patterning cues during organogenesis remain poorly understood. We have investigated the control of Drosophila posterior spiracle morphogenesis, a segment-specific structure that forms under Abdominal-B (AbdB) Hox control in the eighth abdominal segment (A8). We show that the Hedgehog (Hh), Wingless (Wg) and Epidermal Growth Factor Receptor (Egfr) pathways provide specific inputs for posterior spiracle morphogenesis and act in a genetic network made of multiple and rapidly evolving Hox/signalling interplays. A major function of AbdB during posterior spiracle organogenesis is to reset A8 intrasegmental patterning cues, first by reshaping wg and rhomboid expression patterns, then by reallocating the Hh signal and later by initiating de novo expression of the posterior compartment gene engrailed in anterior compartment cells. These changes in expression patterns confer axial specificity to otherwise reiteratively used segmental patterning cues, linking intrasegmental polarity and acquisition of segment identity.This work was supported by the `Centre National de la Recherche Scientifique' (CNRS), grants from `la Ligue Nationale Contre Le Cancer (équipe labellisée La Ligue)', `l'Association pour la Recherche contre le Cancer' (ARC), The Royal Society, The Welcome Trust, the `Minesterio de education y ciencia (BFU 2004 0 96) and ARC and EMBO long term fellowships to S. Merabet.Peer reviewedCompany of Biologists201120112005info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/41257reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1242/dev.01889info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/412572026-05-22T06:33:51Z
dc.title.none.fl_str_mv Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis
title Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis
spellingShingle Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis
Merabet, Samir
Hox
Signalling
Organogenesis
Drosophila
title_short Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis
title_full Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis
title_fullStr Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis
title_full_unstemmed Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis
title_sort Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis
dc.creator.none.fl_str_mv Merabet, Samir
Castelli-Gair Hombría, James
Hu, Nan
Pradel, Jacques
Graba, Yacine
author Merabet, Samir
author_facet Merabet, Samir
Castelli-Gair Hombría, James
Hu, Nan
Pradel, Jacques
Graba, Yacine
author_role author
author2 Castelli-Gair Hombría, James
Hu, Nan
Pradel, Jacques
Graba, Yacine
author2_role author
author
author
author
dc.subject.none.fl_str_mv Hox
Signalling
Organogenesis
Drosophila
topic Hox
Signalling
Organogenesis
Drosophila
description 10 páginas, 8 figuras. Material complementario del artículo esta disponible en http://dev.biologists.org/cgi/content/full/132/13/3093/DC1
publishDate 2005
dc.date.none.fl_str_mv 2005
2011
2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/41257
url http://hdl.handle.net/10261/41257
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1242/dev.01889
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Company of Biologists
publisher.none.fl_str_mv Company of Biologists
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869406012848472064
score 15.812429

Similares en LA Referencia