A structural perspective of compensatory evolution

The study of molecular evolution is important because it reveals how protein functions emerge and evolve. Recently, several types of studies indicated that substitutions in molecular evolution occur in a compensatory manner, whereby the occurrence of a substitution depends on the amino acid residues...

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Detalles Bibliográficos
Autores: Ivankov, Dmitry N., Finkelstein, Alexei V., Kondrashov, Fyodor A., 1979-
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/58840
Acceso en línea:http://hdl.handle.net/10230/58840
http://dx.doi.org/10.1016/j.sbi.2014.05.004
Access Level:acceso abierto
Palabra clave:Proteïnes
Molècules
Aminoàcids
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spelling A structural perspective of compensatory evolutionIvankov, Dmitry N.Finkelstein, Alexei V.Kondrashov, Fyodor A., 1979-ProteïnesMolèculesAminoàcidsThe study of molecular evolution is important because it reveals how protein functions emerge and evolve. Recently, several types of studies indicated that substitutions in molecular evolution occur in a compensatory manner, whereby the occurrence of a substitution depends on the amino acid residues at other sites. However, a molecular or structural basis behind the compensation often remains obscure. Here, we review studies on the interface of structural biology and molecular evolution that revealed novel aspects of compensatory evolution. In many cases structural studies benefit from evolutionary data while structural data often add a functional dimension to the study of molecular evolution.The work has been supported by a grant of the HHMI International Early Career Scientist Program (55007424), the Spanish Ministry of Economy and Competitiveness (EUI-EURYIP-2011-4320) as part of the EMBO YIP program, two grants from the Spanish Ministry of Economy and Competitiveness, ‘Centro de Excelencia Severo Ochoa 2013–2017 (Sev-2012-0208)’ and (BFU2012-31329), the European Union and the European Research Council grant (335980_EinME), RFBR (13-04-00253a), MCB RAS (01201358029) and MES RK Grants.Elsevier202420242014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/58840http://dx.doi.org/10.1016/j.sbi.2014.05.004reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésCurrent Opinion in Structural Biology. 2014 Jun;26:104-12info:eu-repo/grantAgreement/EC/FP7/335980info:eu-repo/grantAgreement/ES/3PN/BFU2012-31329© 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).http://creativecommons.org/licenses/by-nc-nd/3.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/588402026-06-12T07:21:37Z
dc.title.none.fl_str_mv A structural perspective of compensatory evolution
title A structural perspective of compensatory evolution
spellingShingle A structural perspective of compensatory evolution
Ivankov, Dmitry N.
Proteïnes
Molècules
Aminoàcids
title_short A structural perspective of compensatory evolution
title_full A structural perspective of compensatory evolution
title_fullStr A structural perspective of compensatory evolution
title_full_unstemmed A structural perspective of compensatory evolution
title_sort A structural perspective of compensatory evolution
dc.creator.none.fl_str_mv Ivankov, Dmitry N.
Finkelstein, Alexei V.
Kondrashov, Fyodor A., 1979-
author Ivankov, Dmitry N.
author_facet Ivankov, Dmitry N.
Finkelstein, Alexei V.
Kondrashov, Fyodor A., 1979-
author_role author
author2 Finkelstein, Alexei V.
Kondrashov, Fyodor A., 1979-
author2_role author
author
dc.subject.none.fl_str_mv Proteïnes
Molècules
Aminoàcids
topic Proteïnes
Molècules
Aminoàcids
description The study of molecular evolution is important because it reveals how protein functions emerge and evolve. Recently, several types of studies indicated that substitutions in molecular evolution occur in a compensatory manner, whereby the occurrence of a substitution depends on the amino acid residues at other sites. However, a molecular or structural basis behind the compensation often remains obscure. Here, we review studies on the interface of structural biology and molecular evolution that revealed novel aspects of compensatory evolution. In many cases structural studies benefit from evolutionary data while structural data often add a functional dimension to the study of molecular evolution.
publishDate 2014
dc.date.none.fl_str_mv 2014
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/58840
http://dx.doi.org/10.1016/j.sbi.2014.05.004
url http://hdl.handle.net/10230/58840
http://dx.doi.org/10.1016/j.sbi.2014.05.004
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Current Opinion in Structural Biology. 2014 Jun;26:104-12
info:eu-repo/grantAgreement/EC/FP7/335980
info:eu-repo/grantAgreement/ES/3PN/BFU2012-31329
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/3.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/3.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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