Nicotine-induced antinociception, rewarding effects and physical dependence are decreased in mice lacking the preproenkephalin gene

It has been shown previously that the endogenous opioid system may be involved in the behavioral effects of nicotine. In the present study, the participation of endogenous enkephalins on nicotine responses has been investigated by using preproenkephalin knock-out mice. Acute nicotine-induced hypoloc...

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Detalles Bibliográficos
Autores: Berrendero Díaz, Fernando, 1971-, Mendizábal, Victoria, Robledo, Patricia, 1958-, Galeote González, Lola, Bilkei Gorzo, Andras, Zimmer, Andreas, Maldonado, Rafael, 1961-
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2005
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/16662
Acceso en línea:http://hdl.handle.net/10230/16662
http://dx.doi.org/10.1523/JNEUROSCI.3008-04.2005
Access Level:acceso abierto
Palabra clave:Nicotina -- Addicció
Nicotina -- Efectes fisiològics
Receptors nicotínics
Nicotine
Antinociception
Reward
Dependence
Enkephalin
Knock-out mice
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spelling Nicotine-induced antinociception, rewarding effects and physical dependence are decreased in mice lacking the preproenkephalin geneBerrendero Díaz, Fernando, 1971-Mendizábal, VictoriaRobledo, Patricia, 1958-Galeote González, LolaBilkei Gorzo, AndrasZimmer, AndreasMaldonado, Rafael, 1961-Nicotina -- AddiccióNicotina -- Efectes fisiològicsReceptors nicotínicsNicotineAntinociceptionRewardDependenceEnkephalinKnock-out miceIt has been shown previously that the endogenous opioid system may be involved in the behavioral effects of nicotine. In the present study, the participation of endogenous enkephalins on nicotine responses has been investigated by using preproenkephalin knock-out mice. Acute nicotine-induced hypolocomotion remained unaffected in these mice. In contrast, antinociception elicited in the tail-immersion and hot-plate tests by acute nicotine administration was reduced in mutant animals. The rewarding properties of nicotine were then investigated using the place-conditioning paradigm. Nicotine induced a conditioned place preference in wild-type animals, but this effect was absent in knock-out mice. Accordingly, in vivo microdialysis studies revealed that the enhancement in dopamine extracellular levels in the nucleus accumbens induced by nicotine was also reduced in preproenkephalin-deficient mice. Finally, the somatic expression of the nicotine withdrawal syndrome precipitated in nicotine-dependent mice by mecamylamine was significantly attenuated in mutant animals. In summary, the present results indicate that endogenous opioid peptides derived from preproenkephalin are involved in the antinociceptive and rewarding properties of nicotine and participate in the expression of physical nicotine dependence.This work was supported by National Institute on Drug Abuse–National Institutes of Health Grant/n1RO1DA016768, the Human Frontier Science Program Organization (RG0077/2000-B), Generalitat de Catalunya (Distinción de la Generalitat and 2002SGR00193), and Fondo de Investigación Sanitario (FIS) Grants 03/0305, G03/005, and C03/06. P.R. was supported by an FIS investigator contract. V.M. is a postdoctoral fellow supported by Fundación Carolina. F.B. is a researcher supported by the Ramón y Cajal Program of Ministerio de Ciencia y TecnologíaSociety for Neuroscience201220122005info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/16662http://dx.doi.org/10.1523/JNEUROSCI.3008-04.2005reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésJournal of Neuroscience. 2005;25(5):1103-12© 2005, Society for Neuroscience. The published version is available at: http://www.jneurosci.org/content/25/5/1103info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/166622026-06-12T07:21:37Z
dc.title.none.fl_str_mv Nicotine-induced antinociception, rewarding effects and physical dependence are decreased in mice lacking the preproenkephalin gene
title Nicotine-induced antinociception, rewarding effects and physical dependence are decreased in mice lacking the preproenkephalin gene
spellingShingle Nicotine-induced antinociception, rewarding effects and physical dependence are decreased in mice lacking the preproenkephalin gene
Berrendero Díaz, Fernando, 1971-
Nicotina -- Addicció
Nicotina -- Efectes fisiològics
Receptors nicotínics
Nicotine
Antinociception
Reward
Dependence
Enkephalin
Knock-out mice
title_short Nicotine-induced antinociception, rewarding effects and physical dependence are decreased in mice lacking the preproenkephalin gene
title_full Nicotine-induced antinociception, rewarding effects and physical dependence are decreased in mice lacking the preproenkephalin gene
title_fullStr Nicotine-induced antinociception, rewarding effects and physical dependence are decreased in mice lacking the preproenkephalin gene
title_full_unstemmed Nicotine-induced antinociception, rewarding effects and physical dependence are decreased in mice lacking the preproenkephalin gene
title_sort Nicotine-induced antinociception, rewarding effects and physical dependence are decreased in mice lacking the preproenkephalin gene
dc.creator.none.fl_str_mv Berrendero Díaz, Fernando, 1971-
Mendizábal, Victoria
Robledo, Patricia, 1958-
Galeote González, Lola
Bilkei Gorzo, Andras
Zimmer, Andreas
Maldonado, Rafael, 1961-
author Berrendero Díaz, Fernando, 1971-
author_facet Berrendero Díaz, Fernando, 1971-
Mendizábal, Victoria
Robledo, Patricia, 1958-
Galeote González, Lola
Bilkei Gorzo, Andras
Zimmer, Andreas
Maldonado, Rafael, 1961-
author_role author
author2 Mendizábal, Victoria
Robledo, Patricia, 1958-
Galeote González, Lola
Bilkei Gorzo, Andras
Zimmer, Andreas
Maldonado, Rafael, 1961-
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Nicotina -- Addicció
Nicotina -- Efectes fisiològics
Receptors nicotínics
Nicotine
Antinociception
Reward
Dependence
Enkephalin
Knock-out mice
topic Nicotina -- Addicció
Nicotina -- Efectes fisiològics
Receptors nicotínics
Nicotine
Antinociception
Reward
Dependence
Enkephalin
Knock-out mice
description It has been shown previously that the endogenous opioid system may be involved in the behavioral effects of nicotine. In the present study, the participation of endogenous enkephalins on nicotine responses has been investigated by using preproenkephalin knock-out mice. Acute nicotine-induced hypolocomotion remained unaffected in these mice. In contrast, antinociception elicited in the tail-immersion and hot-plate tests by acute nicotine administration was reduced in mutant animals. The rewarding properties of nicotine were then investigated using the place-conditioning paradigm. Nicotine induced a conditioned place preference in wild-type animals, but this effect was absent in knock-out mice. Accordingly, in vivo microdialysis studies revealed that the enhancement in dopamine extracellular levels in the nucleus accumbens induced by nicotine was also reduced in preproenkephalin-deficient mice. Finally, the somatic expression of the nicotine withdrawal syndrome precipitated in nicotine-dependent mice by mecamylamine was significantly attenuated in mutant animals. In summary, the present results indicate that endogenous opioid peptides derived from preproenkephalin are involved in the antinociceptive and rewarding properties of nicotine and participate in the expression of physical nicotine dependence.
publishDate 2005
dc.date.none.fl_str_mv 2005
2012
2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/16662
http://dx.doi.org/10.1523/JNEUROSCI.3008-04.2005
url http://hdl.handle.net/10230/16662
http://dx.doi.org/10.1523/JNEUROSCI.3008-04.2005
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Neuroscience. 2005;25(5):1103-12
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Society for Neuroscience
publisher.none.fl_str_mv Society for Neuroscience
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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