Different mechanisms that promote protein monoubiquitination
Protein monoubiquitination is a post-translational modification that consists of the conjugation of a single ubiquitin molecule to a target protein residue. Monoubiquitination regulates protein activity and localization and is involved in DNA repair, histone regulation, and receptor endocytosis. Alt...
| Autores: | , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2015 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:20.500.14342/1143 |
| Acceso en línea: | http://hdl.handle.net/20.500.14342/1143 |
| Access Level: | acceso abierto |
| Palabra clave: | Ubiqüitina Proteïnes Metabolisme cel·lular Coupled monoubiquitination Monoubiquitination Post-translational modification Ubiquitin Monoubicuitinación Monoubicuitinación acoblada Modificación post-traduccional Ubicuitina Monoubicuitinació Monoubicuitinació acoblada Modificació post-traduccional 577 |
| Sumario: | Protein monoubiquitination is a post-translational modification that consists of the conjugation of a single ubiquitin molecule to a target protein residue. Monoubiquitination regulates protein activity and localization and is involved in DNA repair, histone regulation, and receptor endocytosis. Although the mechanisms by which monoubiquitination regulates protein function are still not well understood, there are some insights into the mechanisms that promote this modification. In this work, we discuss some of the principles of the processes that produce monoubiquitination in vivo; i.e., how ubiquitin conjugating enzymes, ubiquitin ligases or other co-factors can produce direct substrates monoubiquitination, and how ubiquitin specific proteases can indirectly convert polyubiquitinated to monoubiquitinated proteins. |
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