Use of polygenic risk scores to assess weight loss after bariatric surgery: a 5-year follow-up study

Background: Bariatric surgery (BS) is currently the most effective long-term treatment of severe obesity. However, the interindividual variability observed in surgical outcomes suggests a moderating effect of several factors, including individual genetic background. This study aimed to investigate t...

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Autores: Peña, E, Mas-Bermejo, P, Lecube, A, Ciudin, A, Arenas, C, Simó, R, Rigla, M, Caixàs, A, Rosa, A
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p5307
Acceso en línea:https://i3pt.portalinvestigacion.com/publicaciones/5307
Access Level:acceso abierto
Palabra clave:Bariatric surgery
Follow-up
Obesity
Polygenic risk scores
Weight loss
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spelling Use of polygenic risk scores to assess weight loss after bariatric surgery: a 5-year follow-up studyPeña, EMas-Bermejo, PLecube, ACiudin, AArenas, CSimó, RRigla, MCaixàs, ARosa, ABariatric surgeryFollow-upObesityPolygenic risk scoresWeight lossBackground: Bariatric surgery (BS) is currently the most effective long-term treatment of severe obesity. However, the interindividual variability observed in surgical outcomes suggests a moderating effect of several factors, including individual genetic background. This study aimed to investigate the contribution of the genetic architecture of body mass index (BMI) to the variability in weight loss outcomes after BS. Methods: A total of 106 patients with severe obesity who underwent Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy were followed up for 5 years. Changes in BMI (BMIchange) and percentage of total weight loss (%TWL) were evaluated during the postoperative period. Polygenic risk scores (PRSs), including 50 genetic variants, were calculated for each participant to determine their genetic risk of high BMI based on a previous genome-wide association study. Generalized estimating equation models were used to study the role of the individual's polygenic score and other factors on BMIchange and %TWL in the long term after surgery. Results: This study found an effect of the polygenic score on %TWL and BMIchange, in which patients with lower scores had better outcomes after surgery than those with higher scores. Furthermore, when analyzing only patients who underwent RYGB, the results were replicated, showing greater weight loss after surgery for patients with lower polygenic scores. Discussion: Our results indicate that genetic background assessed with PRSs, along with other individual factors, such as biological sex, age, and preoperative BMI, has an effect on BS outcomes and could represent a useful tool for estimating surgical outcomes in advance. (c) 2024 The Author(s). Published by Elsevier Inc. on behalf of Society for Surgery of the Alimentary Tract. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-ncnd/4.0/).ELSEVIER SCIENCE INC2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/5307JOURNAL OF GASTROINTESTINAL SURGERYISSN: 1091255XISSNe: 18734626reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p53072026-06-21T15:30:37Z
dc.title.none.fl_str_mv Use of polygenic risk scores to assess weight loss after bariatric surgery: a 5-year follow-up study
title Use of polygenic risk scores to assess weight loss after bariatric surgery: a 5-year follow-up study
spellingShingle Use of polygenic risk scores to assess weight loss after bariatric surgery: a 5-year follow-up study
Peña, E
Bariatric surgery
Follow-up
Obesity
Polygenic risk scores
Weight loss
title_short Use of polygenic risk scores to assess weight loss after bariatric surgery: a 5-year follow-up study
title_full Use of polygenic risk scores to assess weight loss after bariatric surgery: a 5-year follow-up study
title_fullStr Use of polygenic risk scores to assess weight loss after bariatric surgery: a 5-year follow-up study
title_full_unstemmed Use of polygenic risk scores to assess weight loss after bariatric surgery: a 5-year follow-up study
title_sort Use of polygenic risk scores to assess weight loss after bariatric surgery: a 5-year follow-up study
dc.creator.none.fl_str_mv Peña, E
Mas-Bermejo, P
Lecube, A
Ciudin, A
Arenas, C
Simó, R
Rigla, M
Caixàs, A
Rosa, A
author Peña, E
author_facet Peña, E
Mas-Bermejo, P
Lecube, A
Ciudin, A
Arenas, C
Simó, R
Rigla, M
Caixàs, A
Rosa, A
author_role author
author2 Mas-Bermejo, P
Lecube, A
Ciudin, A
Arenas, C
Simó, R
Rigla, M
Caixàs, A
Rosa, A
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Bariatric surgery
Follow-up
Obesity
Polygenic risk scores
Weight loss
topic Bariatric surgery
Follow-up
Obesity
Polygenic risk scores
Weight loss
description Background: Bariatric surgery (BS) is currently the most effective long-term treatment of severe obesity. However, the interindividual variability observed in surgical outcomes suggests a moderating effect of several factors, including individual genetic background. This study aimed to investigate the contribution of the genetic architecture of body mass index (BMI) to the variability in weight loss outcomes after BS. Methods: A total of 106 patients with severe obesity who underwent Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy were followed up for 5 years. Changes in BMI (BMIchange) and percentage of total weight loss (%TWL) were evaluated during the postoperative period. Polygenic risk scores (PRSs), including 50 genetic variants, were calculated for each participant to determine their genetic risk of high BMI based on a previous genome-wide association study. Generalized estimating equation models were used to study the role of the individual's polygenic score and other factors on BMIchange and %TWL in the long term after surgery. Results: This study found an effect of the polygenic score on %TWL and BMIchange, in which patients with lower scores had better outcomes after surgery than those with higher scores. Furthermore, when analyzing only patients who underwent RYGB, the results were replicated, showing greater weight loss after surgery for patients with lower polygenic scores. Discussion: Our results indicate that genetic background assessed with PRSs, along with other individual factors, such as biological sex, age, and preoperative BMI, has an effect on BS outcomes and could represent a useful tool for estimating surgical outcomes in advance. (c) 2024 The Author(s). Published by Elsevier Inc. on behalf of Society for Surgery of the Alimentary Tract. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-ncnd/4.0/).
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://i3pt.portalinvestigacion.com/publicaciones/5307
url https://i3pt.portalinvestigacion.com/publicaciones/5307
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER SCIENCE INC
publisher.none.fl_str_mv ELSEVIER SCIENCE INC
dc.source.none.fl_str_mv JOURNAL OF GASTROINTESTINAL SURGERY
ISSN: 1091255X
ISSNe: 18734626
reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
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repository.mail.fl_str_mv
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