Antecedentes familiares de primer grado como factor de riesgo en el cáncer colorrectal

Objective: To evaluate the association between first-degree family history and colorectal cancer (CRC). Method: We analyzed data from 2857 controls and 1360 CRC cases, collected in the MCC-Spain project. The adjusted odds ratio (OR) and 95% confidence interval (95% CI) of association with the family...

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Detalles Bibliográficos
Autores: Rubín García, María, Martín, Vicente, Vitelli Storelli, Facundo, Moreno Aguado, Víctor, Aragonés, Nuria, Ardanaz, Eva, Alonso Molero, Jéssica, Jiménez Moleón, José Juan, Amiano, Pilar, Fernández Tardón, Guillermo, Molina Barceló, Ana, Alguacil, Juan, Chirlaque, María Dolores, Álvarez Álvarez, Laura, Pérez Gómez, Beatriz, Dierssen Sotos, Trinidad, Olmedo Requena, Rocío, Guevara, Marcela, Fernández Villa, Tania, Pollán, Marina, Benavente, Yolanda
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/188899
Acceso en línea:https://hdl.handle.net/2445/188899
Access Level:acceso abierto
Palabra clave:Càncer colorectal
Factors de risc en les malalties
Malalties hereditàries
Colorectal cancer
Risk factors in diseases
Genetic diseases
Descripción
Sumario:Objective: To evaluate the association between first-degree family history and colorectal cancer (CRC). Method: We analyzed data from 2857 controls and 1360 CRC cases, collected in the MCC-Spain project. The adjusted odds ratio (OR) and 95% confidence interval (95% CI) of association with the family history of CRC was estimated by non-conditional logistic regression. Result: First-degree relatives doubled the risk of CRC (OR: 2.19; 95% CI: 1.80-2.66), increasing in those with two or more (OR: 4.22; 95% CI: 2.29-7.78) and in those whose relatives were diagnosed before 50 years (OR: 3.24; 95% CI: 1.52-6.91). Regarding the association of the family history with the location, no significant differences were observed between colon and rectum, but there were in the relation of these with the age of diagnosis, having more relatives those diagnosed before 50 years (OR: 4.79; 95% CI: 2.65-8.65). Conclusions: First-degree relatives of CRC increase the chances of developing this tumor, they also increase when the relative is diagnosed at an early age. Therefore, it must be a target population on which to carry out prevention measures.

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