Adverse Drug Reactions in Pediatric Oncohematology: A Systematic Review
Adverse drug reactions; Neoplasms; Pediatrics
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:11351/8871 |
| Acceso en línea: | https://hdl.handle.net/11351/8871 |
| Access Level: | acceso abierto |
| Palabra clave: | Hematologia oncològica Càncer - Tractament Medicaments - Efectes secundaris DISEASES::Hemic and Lymphatic Diseases::Hematologic Diseases Other subheadings::Other subheadings::Other subheadings::/drug therapy CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents Other subheadings::Other subheadings::Other subheadings::/adverse effects ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias hematológicas Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antineoplásicos Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos |
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Adverse Drug Reactions in Pediatric Oncohematology: A Systematic ReviewAmaro Hosey, KristopherDanés Carreras, ImmaculadaAgustí, AntòniaHematologia oncològicaCàncer - TractamentMedicaments - Efectes secundarisDISEASES::Hemic and Lymphatic Diseases::Hematologic DiseasesOther subheadings::Other subheadings::Other subheadings::/drug therapyCHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic AgentsOther subheadings::Other subheadings::Other subheadings::/adverse effectsENFERMEDADES::neoplasias::neoplasias por localización::neoplasias hematológicasOtros calificadores::Otros calificadores::Otros calificadores::/farmacoterapiaCOMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antineoplásicosOtros calificadores::Otros calificadores::Otros calificadores::/efectos adversosAdverse drug reactions; Neoplasms; PediatricsReacciones adversas a medicamentos; Neoplasias; PediatríaReaccions adverses als medicaments; Neoplàsies; PediatriaIntroduction: Adverse drug reactions (ADR) are an important cause of morbidity and mortality in pediatric patients. Due to the disease severity and chemotherapy safety profile, oncologic patients are at higher risk of ADR. However, there is little evidence on pharmacovigilance studies evaluating drug safety in this specific population. Methods: In order to assess the incidence and characteristics of ADR in pediatric patients with oncohematogical diseases and the methodology used in the studies, a systematic review was carried out using both free search and a combination of MeSH terms. Data extraction and critical appraisal were performed independently using a predefined form. Results: Fourteen studies were included, of which eight were prospective and half focused in inpatients. Sample size and study duration varied widely. Different methods of ADR identification were detected, used alone or combined. Causality and severity were assessed frequently, whereas preventability was lacking in most studies. ADR incidence varied between 14.4 and 67% in inpatients, and 19.6–68.1% in admissions, mainly in the form of hematological, gastrointestinal and skin toxicity. Between 11 and 16.4% ADR were considered severe, and preventability ranged from 0 to 74.5%. Conclusion: ADR in oncohematology pediatric patients are frequent. A high variability in study design and results has been found. The use of methodological standards and preventability assessment should be reinforced in order to allow results comparison between studies and centers, and to detected areas of improvement.Frontiers MediaInstitut Català de la Salut[Amaro-Hosey K] Clinical Pharmacology Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. Departament de Farmacologia, Terapèutica i Toxicologia, Universitat Autònoma de Barcelona, Bellaterra, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Danés I, Agustí A] Departament de Farmacologia, Terapèutica i Toxicologia, Universitat Autònoma de Barcelona, Bellaterra, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Farmacologia Clínica, Vall d’Hebron Hospital Universitari, Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202320232022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/8871Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésFrontiers in Pharmacology;12https://doi.org/10.3389/fphar.2021.777498Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/88712026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Adverse Drug Reactions in Pediatric Oncohematology: A Systematic Review |
| title |
Adverse Drug Reactions in Pediatric Oncohematology: A Systematic Review |
| spellingShingle |
Adverse Drug Reactions in Pediatric Oncohematology: A Systematic Review Amaro Hosey, Kristopher Hematologia oncològica Càncer - Tractament Medicaments - Efectes secundaris DISEASES::Hemic and Lymphatic Diseases::Hematologic Diseases Other subheadings::Other subheadings::Other subheadings::/drug therapy CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents Other subheadings::Other subheadings::Other subheadings::/adverse effects ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias hematológicas Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antineoplásicos Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos |
| title_short |
Adverse Drug Reactions in Pediatric Oncohematology: A Systematic Review |
| title_full |
Adverse Drug Reactions in Pediatric Oncohematology: A Systematic Review |
| title_fullStr |
Adverse Drug Reactions in Pediatric Oncohematology: A Systematic Review |
| title_full_unstemmed |
Adverse Drug Reactions in Pediatric Oncohematology: A Systematic Review |
| title_sort |
Adverse Drug Reactions in Pediatric Oncohematology: A Systematic Review |
| dc.creator.none.fl_str_mv |
Amaro Hosey, Kristopher Danés Carreras, Immaculada Agustí, Antònia |
| author |
Amaro Hosey, Kristopher |
| author_facet |
Amaro Hosey, Kristopher Danés Carreras, Immaculada Agustí, Antònia |
| author_role |
author |
| author2 |
Danés Carreras, Immaculada Agustí, Antònia |
| author2_role |
author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut [Amaro-Hosey K] Clinical Pharmacology Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. Departament de Farmacologia, Terapèutica i Toxicologia, Universitat Autònoma de Barcelona, Bellaterra, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Danés I, Agustí A] Departament de Farmacologia, Terapèutica i Toxicologia, Universitat Autònoma de Barcelona, Bellaterra, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Farmacologia Clínica, Vall d’Hebron Hospital Universitari, Barcelona, Spain Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Hematologia oncològica Càncer - Tractament Medicaments - Efectes secundaris DISEASES::Hemic and Lymphatic Diseases::Hematologic Diseases Other subheadings::Other subheadings::Other subheadings::/drug therapy CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents Other subheadings::Other subheadings::Other subheadings::/adverse effects ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias hematológicas Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antineoplásicos Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos |
| topic |
Hematologia oncològica Càncer - Tractament Medicaments - Efectes secundaris DISEASES::Hemic and Lymphatic Diseases::Hematologic Diseases Other subheadings::Other subheadings::Other subheadings::/drug therapy CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents Other subheadings::Other subheadings::Other subheadings::/adverse effects ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias hematológicas Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antineoplásicos Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos |
| description |
Adverse drug reactions; Neoplasms; Pediatrics |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2023 2023 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://hdl.handle.net/11351/8871 |
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https://hdl.handle.net/11351/8871 |
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Inglés |
| language_invalid_str_mv |
Inglés |
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Frontiers in Pharmacology;12 https://doi.org/10.3389/fphar.2021.777498 |
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Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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Frontiers Media |
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Frontiers Media |
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Scientia reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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