Adverse Drug Reactions in Pediatric Oncohematology: A Systematic Review

Adverse drug reactions; Neoplasms; Pediatrics

Detalles Bibliográficos
Autores: Amaro Hosey, Kristopher, Danés Carreras, Immaculada, Agustí, Antònia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/8871
Acceso en línea:https://hdl.handle.net/11351/8871
Access Level:acceso abierto
Palabra clave:Hematologia oncològica
Càncer - Tractament
Medicaments - Efectes secundaris
DISEASES::Hemic and Lymphatic Diseases::Hematologic Diseases
Other subheadings::Other subheadings::Other subheadings::/drug therapy
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents
Other subheadings::Other subheadings::Other subheadings::/adverse effects
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias hematológicas
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antineoplásicos
Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos
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spelling Adverse Drug Reactions in Pediatric Oncohematology: A Systematic ReviewAmaro Hosey, KristopherDanés Carreras, ImmaculadaAgustí, AntòniaHematologia oncològicaCàncer - TractamentMedicaments - Efectes secundarisDISEASES::Hemic and Lymphatic Diseases::Hematologic DiseasesOther subheadings::Other subheadings::Other subheadings::/drug therapyCHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic AgentsOther subheadings::Other subheadings::Other subheadings::/adverse effectsENFERMEDADES::neoplasias::neoplasias por localización::neoplasias hematológicasOtros calificadores::Otros calificadores::Otros calificadores::/farmacoterapiaCOMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antineoplásicosOtros calificadores::Otros calificadores::Otros calificadores::/efectos adversosAdverse drug reactions; Neoplasms; PediatricsReacciones adversas a medicamentos; Neoplasias; PediatríaReaccions adverses als medicaments; Neoplàsies; PediatriaIntroduction: Adverse drug reactions (ADR) are an important cause of morbidity and mortality in pediatric patients. Due to the disease severity and chemotherapy safety profile, oncologic patients are at higher risk of ADR. However, there is little evidence on pharmacovigilance studies evaluating drug safety in this specific population. Methods: In order to assess the incidence and characteristics of ADR in pediatric patients with oncohematogical diseases and the methodology used in the studies, a systematic review was carried out using both free search and a combination of MeSH terms. Data extraction and critical appraisal were performed independently using a predefined form. Results: Fourteen studies were included, of which eight were prospective and half focused in inpatients. Sample size and study duration varied widely. Different methods of ADR identification were detected, used alone or combined. Causality and severity were assessed frequently, whereas preventability was lacking in most studies. ADR incidence varied between 14.4 and 67% in inpatients, and 19.6–68.1% in admissions, mainly in the form of hematological, gastrointestinal and skin toxicity. Between 11 and 16.4% ADR were considered severe, and preventability ranged from 0 to 74.5%. Conclusion: ADR in oncohematology pediatric patients are frequent. A high variability in study design and results has been found. The use of methodological standards and preventability assessment should be reinforced in order to allow results comparison between studies and centers, and to detected areas of improvement.Frontiers MediaInstitut Català de la Salut[Amaro-Hosey K] Clinical Pharmacology Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. Departament de Farmacologia, Terapèutica i Toxicologia, Universitat Autònoma de Barcelona, Bellaterra, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Danés I, Agustí A] Departament de Farmacologia, Terapèutica i Toxicologia, Universitat Autònoma de Barcelona, Bellaterra, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Farmacologia Clínica, Vall d’Hebron Hospital Universitari, Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202320232022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/8871Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésFrontiers in Pharmacology;12https://doi.org/10.3389/fphar.2021.777498Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/88712026-05-29T05:05:01Z
dc.title.none.fl_str_mv Adverse Drug Reactions in Pediatric Oncohematology: A Systematic Review
title Adverse Drug Reactions in Pediatric Oncohematology: A Systematic Review
spellingShingle Adverse Drug Reactions in Pediatric Oncohematology: A Systematic Review
Amaro Hosey, Kristopher
Hematologia oncològica
Càncer - Tractament
Medicaments - Efectes secundaris
DISEASES::Hemic and Lymphatic Diseases::Hematologic Diseases
Other subheadings::Other subheadings::Other subheadings::/drug therapy
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents
Other subheadings::Other subheadings::Other subheadings::/adverse effects
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias hematológicas
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antineoplásicos
Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos
title_short Adverse Drug Reactions in Pediatric Oncohematology: A Systematic Review
title_full Adverse Drug Reactions in Pediatric Oncohematology: A Systematic Review
title_fullStr Adverse Drug Reactions in Pediatric Oncohematology: A Systematic Review
title_full_unstemmed Adverse Drug Reactions in Pediatric Oncohematology: A Systematic Review
title_sort Adverse Drug Reactions in Pediatric Oncohematology: A Systematic Review
dc.creator.none.fl_str_mv Amaro Hosey, Kristopher
Danés Carreras, Immaculada
Agustí, Antònia
author Amaro Hosey, Kristopher
author_facet Amaro Hosey, Kristopher
Danés Carreras, Immaculada
Agustí, Antònia
author_role author
author2 Danés Carreras, Immaculada
Agustí, Antònia
author2_role author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Amaro-Hosey K] Clinical Pharmacology Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. Departament de Farmacologia, Terapèutica i Toxicologia, Universitat Autònoma de Barcelona, Bellaterra, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Danés I, Agustí A] Departament de Farmacologia, Terapèutica i Toxicologia, Universitat Autònoma de Barcelona, Bellaterra, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Farmacologia Clínica, Vall d’Hebron Hospital Universitari, Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Hematologia oncològica
Càncer - Tractament
Medicaments - Efectes secundaris
DISEASES::Hemic and Lymphatic Diseases::Hematologic Diseases
Other subheadings::Other subheadings::Other subheadings::/drug therapy
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents
Other subheadings::Other subheadings::Other subheadings::/adverse effects
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias hematológicas
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antineoplásicos
Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos
topic Hematologia oncològica
Càncer - Tractament
Medicaments - Efectes secundaris
DISEASES::Hemic and Lymphatic Diseases::Hematologic Diseases
Other subheadings::Other subheadings::Other subheadings::/drug therapy
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents
Other subheadings::Other subheadings::Other subheadings::/adverse effects
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias hematológicas
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antineoplásicos
Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos
description Adverse drug reactions; Neoplasms; Pediatrics
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/8871
url https://hdl.handle.net/11351/8871
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Frontiers in Pharmacology;12
https://doi.org/10.3389/fphar.2021.777498
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
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