NcRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery

Non-coding RNAs (ncRNAs) are emerging therapeutic tools but there are barriers to their translation to clinical practice. Key issues concern the specificity of the targets, the delivery of the molecules, and their stability, while avoiding "on-target" and "off-target" side effect...

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Autores: Hueso Val, Miguel, Mallén, Adrián, Suñé Pou, Marc, Aran Perramon, Josep M., Suñé i Negre, Josep M. (Josep Maria), Navarro, Estanis
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/181697
Acceso en línea:https://hdl.handle.net/2445/181697
Access Level:acceso abierto
Palabra clave:Nanomedicina
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Nanomedicine
Nucleic acids
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spelling NcRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug DeliveryHueso Val, MiguelMallén, AdriánSuñé Pou, MarcAran Perramon, Josep M.Suñé i Negre, Josep M. (Josep Maria)Navarro, EstanisNanomedicinaÀcids nucleicsNanomedicineNucleic acidsNon-coding RNAs (ncRNAs) are emerging therapeutic tools but there are barriers to their translation to clinical practice. Key issues concern the specificity of the targets, the delivery of the molecules, and their stability, while avoiding "on-target" and "off-target" side effects. In this "ncRNA in therapeutics" issue, we collect several studies of the differential expression of ncRNAs in cardiovascular diseases, bone metabolism-related disorders, neurology, and oncology, and their potential to be used as biomarkers or therapeutic targets. Moreover, we review recent advances in the use of antisense ncRNAs in targeted therapies with a particular emphasis on their basic biological mechanisms, their translational potential, and future trends.MDPI AG2021202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion15 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/181697Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/ijms222111596International Journal of Molecular Sciences, 2021, vol. 22, num. 21, p. 11596https://doi.org/10.3390/ijms222111596cc by (c) Hueso Val, Miguel et al, 2021http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1816972026-05-29T05:05:01Z
dc.title.none.fl_str_mv NcRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery
title NcRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery
spellingShingle NcRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery
Hueso Val, Miguel
Nanomedicina
Àcids nucleics
Nanomedicine
Nucleic acids
title_short NcRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery
title_full NcRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery
title_fullStr NcRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery
title_full_unstemmed NcRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery
title_sort NcRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery
dc.creator.none.fl_str_mv Hueso Val, Miguel
Mallén, Adrián
Suñé Pou, Marc
Aran Perramon, Josep M.
Suñé i Negre, Josep M. (Josep Maria)
Navarro, Estanis
author Hueso Val, Miguel
author_facet Hueso Val, Miguel
Mallén, Adrián
Suñé Pou, Marc
Aran Perramon, Josep M.
Suñé i Negre, Josep M. (Josep Maria)
Navarro, Estanis
author_role author
author2 Mallén, Adrián
Suñé Pou, Marc
Aran Perramon, Josep M.
Suñé i Negre, Josep M. (Josep Maria)
Navarro, Estanis
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Nanomedicina
Àcids nucleics
Nanomedicine
Nucleic acids
topic Nanomedicina
Àcids nucleics
Nanomedicine
Nucleic acids
description Non-coding RNAs (ncRNAs) are emerging therapeutic tools but there are barriers to their translation to clinical practice. Key issues concern the specificity of the targets, the delivery of the molecules, and their stability, while avoiding "on-target" and "off-target" side effects. In this "ncRNA in therapeutics" issue, we collect several studies of the differential expression of ncRNAs in cardiovascular diseases, bone metabolism-related disorders, neurology, and oncology, and their potential to be used as biomarkers or therapeutic targets. Moreover, we review recent advances in the use of antisense ncRNAs in targeted therapies with a particular emphasis on their basic biological mechanisms, their translational potential, and future trends.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/181697
url https://hdl.handle.net/2445/181697
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/ijms222111596
International Journal of Molecular Sciences, 2021, vol. 22, num. 21, p. 11596
https://doi.org/10.3390/ijms222111596
dc.rights.none.fl_str_mv cc by (c) Hueso Val, Miguel et al, 2021
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Hueso Val, Miguel et al, 2021
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 15 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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