Effects of insulin-induced hypoglycemia on somatostatin level and binding in rat cerebral cortex and hippocampus

The effects of severe insulin-induced hypoglycemia on somatostatin level and specific binding in the cerebral cortex and hippocampus were examined using 125I-Tyr11-somatostatin as a ligand. Severe insulin-induced hypoglycemia did not affect the level of somatostatin-like immunoreactivity in the brai...

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Autores: Rodríguez Sánchez, María Nelly, Colás Escudero, María Begoña|||0000-0001-7913-3006, Prieto Villapún, Juan Carlos, Arilla Ferreiro, Eduardo
Tipo de recurso: artículo
Fecha de publicación:1989
País:España
Institución:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:ebuah.uah.es:10017/6947
Acceso en línea:http://hdl.handle.net/10017/6947
https://dx.doi.org/10.1016/0006-8993(89)90141-8
Access Level:acceso abierto
Palabra clave:Insulin-induced hypoglycemia
Somatostatin
Cerebral cortex
Hippocampus
Rat
Bioquímica
Ciencia
Biochemistry
Science
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spelling Effects of insulin-induced hypoglycemia on somatostatin level and binding in rat cerebral cortex and hippocampusRodríguez Sánchez, María NellyColás Escudero, María Begoña|||0000-0001-7913-3006Prieto Villapún, Juan CarlosArilla Ferreiro, EduardoInsulin-induced hypoglycemiaSomatostatinCerebral cortexHippocampusRatBioquímicaCienciaBiochemistryScienceThe effects of severe insulin-induced hypoglycemia on somatostatin level and specific binding in the cerebral cortex and hippocampus were examined using 125I-Tyr11-somatostatin as a ligand. Severe insulin-induced hypoglycemia did not affect the level of somatostatin-like immunoreactivity in the brain areas studied. However, the number (but not the affinity) of specific somatostatin receptors was significantly decreased in membrane preparation from the hippocampus but not in the cerebral cortex at the onset of hypoglycemia coma (5-10 min). Administration of glucose at the onset of hypoglycemic coma brought about extensive recovery of hippocampal somatostatin receptor number. These results suggest that glucose modulates the somatostatin receptor in the rat hippocampus. The physiological significance of these findings remains to be clarified.Comisión Interministerial de Ciencia y TecnologíaInstituto de Salud Carlos IIIElsevier19891989-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/6947https://dx.doi.org/10.1016/0006-8993(89)90141-8reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)InglésengCICYT Not available PB87%2F0753 Estudio de las bases moleculares e inhibición de la proliferación celular inducida por la somatostatinaISCIII Not available 88%2F0903open accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/69472026-06-18T11:13:07Z
dc.title.none.fl_str_mv Effects of insulin-induced hypoglycemia on somatostatin level and binding in rat cerebral cortex and hippocampus
title Effects of insulin-induced hypoglycemia on somatostatin level and binding in rat cerebral cortex and hippocampus
spellingShingle Effects of insulin-induced hypoglycemia on somatostatin level and binding in rat cerebral cortex and hippocampus
Rodríguez Sánchez, María Nelly
Insulin-induced hypoglycemia
Somatostatin
Cerebral cortex
Hippocampus
Rat
Bioquímica
Ciencia
Biochemistry
Science
title_short Effects of insulin-induced hypoglycemia on somatostatin level and binding in rat cerebral cortex and hippocampus
title_full Effects of insulin-induced hypoglycemia on somatostatin level and binding in rat cerebral cortex and hippocampus
title_fullStr Effects of insulin-induced hypoglycemia on somatostatin level and binding in rat cerebral cortex and hippocampus
title_full_unstemmed Effects of insulin-induced hypoglycemia on somatostatin level and binding in rat cerebral cortex and hippocampus
title_sort Effects of insulin-induced hypoglycemia on somatostatin level and binding in rat cerebral cortex and hippocampus
dc.creator.none.fl_str_mv Rodríguez Sánchez, María Nelly
Colás Escudero, María Begoña|||0000-0001-7913-3006
Prieto Villapún, Juan Carlos
Arilla Ferreiro, Eduardo
author Rodríguez Sánchez, María Nelly
author_facet Rodríguez Sánchez, María Nelly
Colás Escudero, María Begoña|||0000-0001-7913-3006
Prieto Villapún, Juan Carlos
Arilla Ferreiro, Eduardo
author_role author
author2 Colás Escudero, María Begoña|||0000-0001-7913-3006
Prieto Villapún, Juan Carlos
Arilla Ferreiro, Eduardo
author2_role author
author
author
dc.subject.none.fl_str_mv Insulin-induced hypoglycemia
Somatostatin
Cerebral cortex
Hippocampus
Rat
Bioquímica
Ciencia
Biochemistry
Science
topic Insulin-induced hypoglycemia
Somatostatin
Cerebral cortex
Hippocampus
Rat
Bioquímica
Ciencia
Biochemistry
Science
description The effects of severe insulin-induced hypoglycemia on somatostatin level and specific binding in the cerebral cortex and hippocampus were examined using 125I-Tyr11-somatostatin as a ligand. Severe insulin-induced hypoglycemia did not affect the level of somatostatin-like immunoreactivity in the brain areas studied. However, the number (but not the affinity) of specific somatostatin receptors was significantly decreased in membrane preparation from the hippocampus but not in the cerebral cortex at the onset of hypoglycemia coma (5-10 min). Administration of glucose at the onset of hypoglycemic coma brought about extensive recovery of hippocampal somatostatin receptor number. These results suggest that glucose modulates the somatostatin receptor in the rat hippocampus. The physiological significance of these findings remains to be clarified.
publishDate 1989
dc.date.none.fl_str_mv 1989
1989-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/6947
https://dx.doi.org/10.1016/0006-8993(89)90141-8
url http://hdl.handle.net/10017/6947
https://dx.doi.org/10.1016/0006-8993(89)90141-8
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv CICYT Not available PB87%2F0753 Estudio de las bases moleculares e inhibición de la proliferación celular inducida por la somatostatina
ISCIII Not available 88%2F0903
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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