Evaluation of the interaction between the pesticides chlorantraniliprole and imidacloprid with the ATP-binding cassette transporter G2 (ABCG2): In vitro and in vivo assays
[EN] Pesticides used in agriculture to control pests can also affect non-target animals, such as livestock and humans, through exposure. Pesticide residues found in animal-derived products like milk serve as evidence of exposure in mammals and may pose health risks due to bioaccumulation. Understand...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universidad de León |
| Repositorio: | BULERIA. Repositorio Institucional de la Universidad de León |
| OAI Identifier: | oai:buleria.unileon.es:10612/24969 |
| Acceso en línea: | https://hdl.handle.net/10612/24969 |
| Access Level: | acceso abierto |
| Palabra clave: | Fisiología ABCG2 Pesticides Chlorantraniliprole Imidacloprid Substrates Milk 2401.13 Fisiología Animal |
| Sumario: | [EN] Pesticides used in agriculture to control pests can also affect non-target animals, such as livestock and humans, through exposure. Pesticide residues found in animal-derived products like milk serve as evidence of exposure in mammals and may pose health risks due to bioaccumulation. Understanding the mechanisms of elimination and toxicity of pesticides is essential to minimize their negative impact. The ATP-binding cassette (ABC) transporter ABCG2 is a membrane protein involved in xenobiotic biodisposition and milk secretion. Our purpose was to evaluate its role in the in vitro transport and secretion into milk of two pesticides: chlorantraniliprole and imidacloprid. Using MDCK–II cells transduced with ABCG2, we found that they are effectively transported by murine, ovine and bovine ABCG2. In vivo studies using wild-type and Abcg2-/- mice showed that milk concentration of chlorantraniliprole was affected by Abcg2, potentially leading to toxicological effects and contributing to unwanted xenobiotic residues in milk. |
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