BIOBADATOP Spanish Atopic Dermatitis Registry: Description and Early Findings.

BACKGROUND: In recent years, remarkable improvements in our understanding of atopic dermatitis (AD) have revolutionized treatment perspectives, but access to reliable data from clinical practice is essential. MATERIALS AND METHOD: The Spanish Atopic Dermatitis Registry, BIOBADATOP, is a prospective,...

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Autores: Munera-Campos M, Chicharro P, Gonzalez Quesada A, Flórez Menéndez Á, de la Cueva Dobao P, Gimenez Arnau AM, Gilaberte Calzada Y, Rodríguez Serna M, Montero-Vilchez T, Silvestre JF, Elosua-González M, Del Alcázar E, Santamaría C, Sánchez-Pérez J, Carretero Hernández G, Batalla A, Jin Suh Oh H, Mauleón Fernández C, Curto Barredo L, Bertolín-Colilla M, Navarro Bielsa A, Ballano Ruiz A, Botella Estrada R, Arias Santiago S, Betlloch I, Roustan Gullón G, Rosell Díaz A, Descalzo MA, García-Doval I, Carrascosa JM
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p9579
Acceso en línea:https://isabial.portalinvestigacion.com/publicaciones9579
Access Level:acceso abierto
Palabra clave:Acontecimientos adversos
Adverse events
Atopic dermatitis
Biologics
Biológicos
Dermatitis atópica
Inhibidores de JAK
JAK inhibitors
Registries
Registro prospectivo
Tratamientos
Treatments
Descripción
Sumario:BACKGROUND: In recent years, remarkable improvements in our understanding of atopic dermatitis (AD) have revolutionized treatment perspectives, but access to reliable data from clinical practice is essential. MATERIALS AND METHOD: The Spanish Atopic Dermatitis Registry, BIOBADATOP, is a prospective, multicenter database that collects information on patients of all ages with AD requiring systemic therapy with conventional or novel drugs. We analyzed the registry to describe patient characteristics, diagnoses, treatments, and adverse events (AEs). RESULTS: We studied data entries for 258 patients who had received 347 systemic treatments for AD. Treatment was discontinued in 29.4% of cases, mostly due to a lack of effectiveness (in 10.7% of cases). A total of 132 AEs were described during follow-up. Eighty-six AEs (65%) were linked to a systemic treatment, most commonly dupilumab (39AEs) and cyclosporine (38AEs). The most common AEs were conjunctivitis (11patients), headache (6), hypertrichosis (5), and nausea (4). There was 1severe AE (acute mastoiditis) associated with cyclosporine. CONCLUSIONS: Initial findings on AEs from the Spanish BIOBADATOP registry are limited by short follow-up times precluding comparisons or calculation of crude and adjusted incidence rates. At the time of our analysis, no severe AEs had been reported for novel systemic therapies. BIOBADATOP will help answer questions on the effectiveness and safety of conventional and novel systemic therapies in AD.

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