Taurine Promotes Axonal Regeneration after a Complete Spinal Cord Injury in Lampreys

Taurine is one of the most abundant free amino acids in the brain. It is well known that taurine protects the brain from further damage after a traumatic event. However, only a few ex vivo studies have looked at the possible role of taurine in the regulation of axon regeneration after injury. Here,...

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Detalles Bibliográficos
Autores: Sobrido Cameán, Daniel, Fernández López, Blanca, Pereiro, Natividad, Lafuente, Anunciación, Rodicio Rodicio, María Celina, Barreiro Iglesias, Antón
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/44242
Acceso en línea:https://hdl.handle.net/10347/44242
Access Level:acceso abierto
Palabra clave:Taurine
Spinal cord injury
Lampreys
Axon regeneration
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spelling Taurine Promotes Axonal Regeneration after a Complete Spinal Cord Injury in LampreysSobrido Cameán, DanielFernández López, BlancaPereiro, NatividadLafuente, AnunciaciónRodicio Rodicio, María CelinaBarreiro Iglesias, AntónTaurineSpinal cord injuryLampreysAxon regenerationTaurine is one of the most abundant free amino acids in the brain. It is well known that taurine protects the brain from further damage after a traumatic event. However, only a few ex vivo studies have looked at the possible role of taurine in the regulation of axon regeneration after injury. Here, we aimed to reveal the possible role for taurine in the modulation of axonal regeneration following a complete spinal cord injury (SCI) using lampreys as an animal model. The brainstem of lampreys contains several individually identifiable descending neurons that differ greatly in their capacity for axonal regeneration after SCI. This offers a convenient model to promote or inhibit axonal regrowth in the same in vivo preparation. First, we carried out high performance liquid chromatography experiments to measure taurine levels in the spinal cord following SCI. Our results revealed a statistically significant increase in taurine levels 4 weeks post-lesion, which suggested that taurine might have a positive effect on axonal regrowth. Based on these results, we decided to apply an acute taurine treatment at the site of injury to study its effect on axon regeneration. Results from these experiments show that an acute taurine treatment enhances axonal regeneration following SCI in lampreys. This offers a novel way to try to promote axon regeneration after nervous system injuries in mammalian models.Mary Ann LiebertUniversidade de Santiago de Compostela. Departamento de Bioloxía Funcional20202020-01-0120202020-01-01journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10347/44242reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/442422026-06-15T12:47:27Z
dc.title.none.fl_str_mv Taurine Promotes Axonal Regeneration after a Complete Spinal Cord Injury in Lampreys
title Taurine Promotes Axonal Regeneration after a Complete Spinal Cord Injury in Lampreys
spellingShingle Taurine Promotes Axonal Regeneration after a Complete Spinal Cord Injury in Lampreys
Sobrido Cameán, Daniel
Taurine
Spinal cord injury
Lampreys
Axon regeneration
title_short Taurine Promotes Axonal Regeneration after a Complete Spinal Cord Injury in Lampreys
title_full Taurine Promotes Axonal Regeneration after a Complete Spinal Cord Injury in Lampreys
title_fullStr Taurine Promotes Axonal Regeneration after a Complete Spinal Cord Injury in Lampreys
title_full_unstemmed Taurine Promotes Axonal Regeneration after a Complete Spinal Cord Injury in Lampreys
title_sort Taurine Promotes Axonal Regeneration after a Complete Spinal Cord Injury in Lampreys
dc.creator.none.fl_str_mv Sobrido Cameán, Daniel
Fernández López, Blanca
Pereiro, Natividad
Lafuente, Anunciación
Rodicio Rodicio, María Celina
Barreiro Iglesias, Antón
author Sobrido Cameán, Daniel
author_facet Sobrido Cameán, Daniel
Fernández López, Blanca
Pereiro, Natividad
Lafuente, Anunciación
Rodicio Rodicio, María Celina
Barreiro Iglesias, Antón
author_role author
author2 Fernández López, Blanca
Pereiro, Natividad
Lafuente, Anunciación
Rodicio Rodicio, María Celina
Barreiro Iglesias, Antón
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de Santiago de Compostela. Departamento de Bioloxía Funcional
dc.subject.none.fl_str_mv Taurine
Spinal cord injury
Lampreys
Axon regeneration
topic Taurine
Spinal cord injury
Lampreys
Axon regeneration
description Taurine is one of the most abundant free amino acids in the brain. It is well known that taurine protects the brain from further damage after a traumatic event. However, only a few ex vivo studies have looked at the possible role of taurine in the regulation of axon regeneration after injury. Here, we aimed to reveal the possible role for taurine in the modulation of axonal regeneration following a complete spinal cord injury (SCI) using lampreys as an animal model. The brainstem of lampreys contains several individually identifiable descending neurons that differ greatly in their capacity for axonal regeneration after SCI. This offers a convenient model to promote or inhibit axonal regrowth in the same in vivo preparation. First, we carried out high performance liquid chromatography experiments to measure taurine levels in the spinal cord following SCI. Our results revealed a statistically significant increase in taurine levels 4 weeks post-lesion, which suggested that taurine might have a positive effect on axonal regrowth. Based on these results, we decided to apply an acute taurine treatment at the site of injury to study its effect on axon regeneration. Results from these experiments show that an acute taurine treatment enhances axonal regeneration following SCI in lampreys. This offers a novel way to try to promote axon regeneration after nervous system injuries in mammalian models.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01
2020
2020-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10347/44242
url https://hdl.handle.net/10347/44242
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Mary Ann Liebert
publisher.none.fl_str_mv Mary Ann Liebert
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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