Twenty-year secular trends in infective endocarditis in a teaching hospital

Background. The purpose of this study was to analyze the secular trends of infective endocarditis in a teaching hospital between January 1996 and December 2015. Methods. We report on a single-center retrospective study of patients with left-side valve infective endocarditis. We performed an analysis...

Descripción completa

Detalles Bibliográficos
Autores: Cuervo Requena, Guillermo, Rombauts, Alexander, Caballero, Queralt, Grau, Immaculada, Pujol Rojo, Miquel, Ardanuy Tisaire, María Carmen, Berbel, Dàmaris, Gudiol González, Carlota, Sánchez Salado, Jose Carlos, Ruiz Mayoral, Alejandro, Sbraga, Fabrizio, Gracia-Sánchez, Laura, Peña, Carmen, Carratalà, Jordi
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/172404
Acceso en línea:https://hdl.handle.net/2445/172404
Access Level:acceso abierto
Palabra clave:Endocarditis
Epidemiologia
Epidemiology
id ES_361de97372eee77cc2124ca9e79af0cd
oai_identifier_str oai:diposit.ub.edu:2445/172404
network_acronym_str ES
network_name_str España
repository_id_str
spelling Twenty-year secular trends in infective endocarditis in a teaching hospitalCuervo Requena, GuillermoRombauts, AlexanderCaballero, QueraltGrau, ImmaculadaPujol Rojo, MiquelArdanuy Tisaire, María CarmenBerbel, DàmarisGudiol González, CarlotaSánchez Salado, Jose CarlosRuiz Mayoral, AlejandroSbraga, FabrizioGracia-Sánchez, LauraPeña, CarmenCarratalà, JordiEndocarditisEpidemiologiaEndocarditisEpidemiologyBackground. The purpose of this study was to analyze the secular trends of infective endocarditis in a teaching hospital between January 1996 and December 2015. Methods. We report on a single-center retrospective study of patients with left-side valve infective endocarditis. We performed an analysis of secular trends in the main epidemiological and etiological aspects, as well as clinical outcomes, in 5 successive 4-year periods (P1 to P5). Results. In total, 595 episodes of infective endocarditis were included, of which 76% were community-acquired and 31.3% involved prosthetic valves. Among the cases, 70% occurred in men, and the mean age (SD) was 64.1 (14.3) years. A significant increase in older patients (age ≥70 years) between P1 (15.332%) and P5 (51.9%; P < .001) was observed. The rate of infective endo- carditis on biological prostheses also increased in the prosthetic group, accounting for 30% in P1 and 67.3% in P5 (P < .001). By contrast, there were significant decreases in vascular and immunological phenomena over the study period, with decreases in the presence of moderate to severe valvular insufficiency (75.9% in P1 to 52.6% in P5; P < .001) and valvular surgery (43% in P1 vs 29.6% in P5; P = .006). Finally, overall mortality was 23.9%, and although it was highest in P1, it subsequently remained stable through P2 to P5 (38% in P1 to 20% in P5; P = .004). Conclusions. There has been a significant increase in infective endocarditis in older patients. The decrease in moderate to severe valve regurgitation at diagnosis could explain the stable mortality despite the increase in the mean age of patients over time.Oxford University Press2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/172404Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1093/ofid/ofy183Open Forum Infectious Diseases, 2018, vol. 55, num. 8https://doi.org/10.1093/ofid/ofy183cc-by-nc-nd (c) Cuervo Requena, Guillermo et al., 2018http://creativecommons.org/licenses/by-nc-nd/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1724042026-05-27T06:46:51Z
dc.title.none.fl_str_mv Twenty-year secular trends in infective endocarditis in a teaching hospital
title Twenty-year secular trends in infective endocarditis in a teaching hospital
spellingShingle Twenty-year secular trends in infective endocarditis in a teaching hospital
Cuervo Requena, Guillermo
Endocarditis
Epidemiologia
Endocarditis
Epidemiology
title_short Twenty-year secular trends in infective endocarditis in a teaching hospital
title_full Twenty-year secular trends in infective endocarditis in a teaching hospital
title_fullStr Twenty-year secular trends in infective endocarditis in a teaching hospital
title_full_unstemmed Twenty-year secular trends in infective endocarditis in a teaching hospital
title_sort Twenty-year secular trends in infective endocarditis in a teaching hospital
dc.creator.none.fl_str_mv Cuervo Requena, Guillermo
Rombauts, Alexander
Caballero, Queralt
Grau, Immaculada
Pujol Rojo, Miquel
Ardanuy Tisaire, María Carmen
Berbel, Dàmaris
Gudiol González, Carlota
Sánchez Salado, Jose Carlos
Ruiz Mayoral, Alejandro
Sbraga, Fabrizio
Gracia-Sánchez, Laura
Peña, Carmen
Carratalà, Jordi
author Cuervo Requena, Guillermo
author_facet Cuervo Requena, Guillermo
Rombauts, Alexander
Caballero, Queralt
Grau, Immaculada
Pujol Rojo, Miquel
Ardanuy Tisaire, María Carmen
Berbel, Dàmaris
Gudiol González, Carlota
Sánchez Salado, Jose Carlos
Ruiz Mayoral, Alejandro
Sbraga, Fabrizio
Gracia-Sánchez, Laura
Peña, Carmen
Carratalà, Jordi
author_role author
author2 Rombauts, Alexander
Caballero, Queralt
Grau, Immaculada
Pujol Rojo, Miquel
Ardanuy Tisaire, María Carmen
Berbel, Dàmaris
Gudiol González, Carlota
Sánchez Salado, Jose Carlos
Ruiz Mayoral, Alejandro
Sbraga, Fabrizio
Gracia-Sánchez, Laura
Peña, Carmen
Carratalà, Jordi
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Endocarditis
Epidemiologia
Endocarditis
Epidemiology
topic Endocarditis
Epidemiologia
Endocarditis
Epidemiology
description Background. The purpose of this study was to analyze the secular trends of infective endocarditis in a teaching hospital between January 1996 and December 2015. Methods. We report on a single-center retrospective study of patients with left-side valve infective endocarditis. We performed an analysis of secular trends in the main epidemiological and etiological aspects, as well as clinical outcomes, in 5 successive 4-year periods (P1 to P5). Results. In total, 595 episodes of infective endocarditis were included, of which 76% were community-acquired and 31.3% involved prosthetic valves. Among the cases, 70% occurred in men, and the mean age (SD) was 64.1 (14.3) years. A significant increase in older patients (age ≥70 years) between P1 (15.332%) and P5 (51.9%; P < .001) was observed. The rate of infective endo- carditis on biological prostheses also increased in the prosthetic group, accounting for 30% in P1 and 67.3% in P5 (P < .001). By contrast, there were significant decreases in vascular and immunological phenomena over the study period, with decreases in the presence of moderate to severe valvular insufficiency (75.9% in P1 to 52.6% in P5; P < .001) and valvular surgery (43% in P1 vs 29.6% in P5; P = .006). Finally, overall mortality was 23.9%, and although it was highest in P1, it subsequently remained stable through P2 to P5 (38% in P1 to 20% in P5; P = .004). Conclusions. There has been a significant increase in infective endocarditis in older patients. The decrease in moderate to severe valve regurgitation at diagnosis could explain the stable mortality despite the increase in the mean age of patients over time.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/172404
url https://hdl.handle.net/2445/172404
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1093/ofid/ofy183
Open Forum Infectious Diseases, 2018, vol. 55, num. 8
https://doi.org/10.1093/ofid/ofy183
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Cuervo Requena, Guillermo et al., 2018
http://creativecommons.org/licenses/by-nc-nd/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Cuervo Requena, Guillermo et al., 2018
http://creativecommons.org/licenses/by-nc-nd/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405937496752128
score 15,300719

Similares en LA Referencia