Redox partner interactions in the ATG8 lipidation system in microalgae

Autophagy is a catabolic pathway that functions as a degradative and recycling process to maintain cellular homeostasis in most eukaryotic cells, including photosynthetic organisms such as microalgae. This process involves the formation of double-membrane vesicles called autophagosomes, which engulf...

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Autores: Mallén-Ponce, Manuel J., Gámez-Arcas, Samuel, Pérez-Pérez, María Esther
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/354684
Acceso en línea:http://hdl.handle.net/10261/354684
https://api.elsevier.com/content/abstract/scopus_id/85151866289
Access Level:acceso abierto
Palabra clave:ATG proteins
ATG8 lipidation system
Autophagy
Microalgae
Redox regulation
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spelling Redox partner interactions in the ATG8 lipidation system in microalgaeMallén-Ponce, Manuel J.Gámez-Arcas, SamuelPérez-Pérez, María EstherATG proteinsATG8 lipidation systemAutophagyMicroalgaeRedox regulationAutophagy is a catabolic pathway that functions as a degradative and recycling process to maintain cellular homeostasis in most eukaryotic cells, including photosynthetic organisms such as microalgae. This process involves the formation of double-membrane vesicles called autophagosomes, which engulf the material to be degraded and recycled in lytic compartments. Autophagy is mediated by a set of highly conserved autophagy-related (ATG) proteins that play a fundamental role in the formation of the autophagosome. The ATG8 ubiquitin-like system catalyzes the conjugation of ATG8 to the lipid phosphatidylethanolamine, an essential reaction in the autophagy process. Several studies identified the ATG8 system and other core ATG proteins in photosynthetic eukaryotes. However, how ATG8 lipidation is driven and regulated in these organisms is not fully understood yet. A detailed analysis of representative genomes from the entire microalgal lineage revealed a high conservation of ATG proteins in these organisms with the remarkable exception of red algae, which likely lost ATG genes before diversification. Here, we examine in silico the mechanisms and dynamic interactions between different components of the ATG8 lipidation system in plants and algae. Moreover, we also discuss the role of redox post-translational modifications in the regulation of ATG proteins and the activation of autophagy in these organisms by reactive oxygen species.Ministerio de Ciencia e Innovación (Grants PID2019-110080 GB-I00 and TED2021-130912B–I00 to MEP-P) and a Margarita Salas postdoctoral contract from the Ministerio de UniversidadesPeer reviewedElsevierMinisterio de Ciencia, Innovación y Universidades (España)Ministerio de Universidades (España)Pérez-Pérez, María Esther [0000-0003-0779-6665]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bchttp://hdl.handle.net/10261/354684https://api.elsevier.com/content/abstract/scopus_id/85151866289reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-110080GB-I00https://doi.org/10.1016/j.freeradbiomed.2023.04.004Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3546842026-05-22T06:33:51Z
dc.title.none.fl_str_mv Redox partner interactions in the ATG8 lipidation system in microalgae
title Redox partner interactions in the ATG8 lipidation system in microalgae
spellingShingle Redox partner interactions in the ATG8 lipidation system in microalgae
Mallén-Ponce, Manuel J.
ATG proteins
ATG8 lipidation system
Autophagy
Microalgae
Redox regulation
title_short Redox partner interactions in the ATG8 lipidation system in microalgae
title_full Redox partner interactions in the ATG8 lipidation system in microalgae
title_fullStr Redox partner interactions in the ATG8 lipidation system in microalgae
title_full_unstemmed Redox partner interactions in the ATG8 lipidation system in microalgae
title_sort Redox partner interactions in the ATG8 lipidation system in microalgae
dc.creator.none.fl_str_mv Mallén-Ponce, Manuel J.
Gámez-Arcas, Samuel
Pérez-Pérez, María Esther
author Mallén-Ponce, Manuel J.
author_facet Mallén-Ponce, Manuel J.
Gámez-Arcas, Samuel
Pérez-Pérez, María Esther
author_role author
author2 Gámez-Arcas, Samuel
Pérez-Pérez, María Esther
author2_role author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Ministerio de Universidades (España)
Pérez-Pérez, María Esther [0000-0003-0779-6665]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv ATG proteins
ATG8 lipidation system
Autophagy
Microalgae
Redox regulation
topic ATG proteins
ATG8 lipidation system
Autophagy
Microalgae
Redox regulation
description Autophagy is a catabolic pathway that functions as a degradative and recycling process to maintain cellular homeostasis in most eukaryotic cells, including photosynthetic organisms such as microalgae. This process involves the formation of double-membrane vesicles called autophagosomes, which engulf the material to be degraded and recycled in lytic compartments. Autophagy is mediated by a set of highly conserved autophagy-related (ATG) proteins that play a fundamental role in the formation of the autophagosome. The ATG8 ubiquitin-like system catalyzes the conjugation of ATG8 to the lipid phosphatidylethanolamine, an essential reaction in the autophagy process. Several studies identified the ATG8 system and other core ATG proteins in photosynthetic eukaryotes. However, how ATG8 lipidation is driven and regulated in these organisms is not fully understood yet. A detailed analysis of representative genomes from the entire microalgal lineage revealed a high conservation of ATG proteins in these organisms with the remarkable exception of red algae, which likely lost ATG genes before diversification. Here, we examine in silico the mechanisms and dynamic interactions between different components of the ATG8 lipidation system in plants and algae. Moreover, we also discuss the role of redox post-translational modifications in the regulation of ATG proteins and the activation of autophagy in these organisms by reactive oxygen species.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/354684
https://api.elsevier.com/content/abstract/scopus_id/85151866289
url http://hdl.handle.net/10261/354684
https://api.elsevier.com/content/abstract/scopus_id/85151866289
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-110080GB-I00
https://doi.org/10.1016/j.freeradbiomed.2023.04.004
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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