VIP/VPAC Axis expression in immune-mediated inflammatory disorders: associated miRNA signatures
17 p.
| Autores: | , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universidad de Alcalá (UAH) |
| Repositorio: | e_Buah Biblioteca Digital Universidad de Alcalá |
| Idioma: | inglés |
| OAI Identifier: | oai:dnet:ebuahbibliot::bd19e0afa4f0ac2fee70052a0950bf6c |
| Acceso en línea: | http://hdl.handle.net/10017/69304 https://dx.doi.org/10.3390/ijms23158578 |
| Access Level: | acceso abierto |
| Palabra clave: | VIP VPAC receptors MicroRNAs Immune-mediated inflammatory disorders Rheumatoid arthritis Spondyloarthritis Graves' disease Psoriasis Medicina Medicine |
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VIP/VPAC Axis expression in immune-mediated inflammatory disorders: associated miRNA signaturesLamana Domínguez, AmaliaCastro Vázquez, DavidFuente Flores, Hortensia de laTriguero Martínez, AnaMartínez Hernández, RebecaRevenga Martínez, MarcelinoVillanueva Romero, RaúlLlamas Velasco, MarChicharro Manso, PabloJuarranz Moratilla, YasminaMarazuela Aspiroz, MónicaSales Sanz, MarcoGarcía de Vicuña Pinedo, María del RosarioTomero Muriel, Eva GloriaGonzález Alvaro, IsidoroMartínez Mora, María del CarmenPérez Gomáriz, Rosa MaríaVIPVPAC receptorsMicroRNAsImmune-mediated inflammatory disordersRheumatoid arthritisSpondyloarthritisGraves' diseasePsoriasisMedicinaMedicine17 p.Few studies have considered immune-mediated inflammatory disorders (IMID) together, which is necessary to adequately understand them given they share common mechanisms. Our goal was to investigate the expression of vasoactive intestinal peptide (VIP) and its receptors VPAC1 and VPAC2 in selected IMID, analyze the effect of biological therapies on them, and identify miRNA signatures associated with their expression. Serum VIP levels and mRNA of VPAC and miRNA expression in peripheral blood mononuclear cells were analyzed from 52 patients with psoriasis, rheumatoid arthritis, Graves' disease, or spondyloarthritis and from 38 healthy subjects. IMID patients showed higher levels of VIP and increased expression of VPAC2 compared to controls (p < 0.0001 and p < 0.0192, respectively). Receiver operating characteristic curve analysis showed that the levels of VIP or VPAC2 expression were adequate discriminators capable of identifying IMID. Treatment of IMID patients with anti-TNFα and anti-IL12/23 significantly affected serum VIP levels. We identified miRNA signatures associated with levels of serum VIP and VPAC2 expression, which correlated with IMID diagnosis of the patients. The results indicate that the expression of VIP/VPAC2 is able of identify IMIDs and open up a line of research based on the association between the VIP/VPAC axis and miRNA signatures in immune-mediated diseases.Ministerio de Economía y CompetitividadFondo Europeo de Desarrollo Regional (FEDER)Comunidad de Madrid20222022-08-02journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/69304https://dx.doi.org/10.3390/ijms2315857835955723reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)InglésengISCIII Not available RD21%2F0002%2F004Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Not available RD16%2F0012%2F0008%2F004 Red de Investigación en Inflamación y Enfermedades Reumáticas (RIER)ISCIII Not available PI17%2F00027 EJE VIPISCIII Not available PI20%2F00078 MECANISMOS REGULADORES DE LA EXPRESION, SEÑALIZACION Y FUNCION DE LOS RECEPTORES VPAC PARA VALIDAR SU APLICACION CLINICA EN ENFERMEDADES INFLAMATORIASISCIII Not available PI19-00584 INTEGROMICAS EN ENFERMEDADES TIROIDEAS AUTOINMUNES: MIRNOMA, TRANSCRIPTOMA Y ANALISIS DE CELULA INDIVIDUAL PARA CARACTERIZAR NUEVAS APROXIMACIONES CLINICAS Y VIAS DE SUSCEPTIBILIDAD EN ETAIISCIII Not available PI21%2F01583 ESTUDIO INTEGRATIVO DE LA INFLAMACION SISTEMICA EN DERMATITIS ATOPICA E HIDRADENITIS SUPURATIVA Y SU ASOCIACIÓN CON LA ENFERMEDAD CARDIOVASCULARComunidad de Madrid http://dx.doi.org/10.13039/100012818 TIRONET2-CM B2017%2FBMD-3724open accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:ebuahbibliot::bd19e0afa4f0ac2fee70052a0950bf6c2026-06-18T11:13:07Z |
| dc.title.none.fl_str_mv |
VIP/VPAC Axis expression in immune-mediated inflammatory disorders: associated miRNA signatures |
| title |
VIP/VPAC Axis expression in immune-mediated inflammatory disorders: associated miRNA signatures |
| spellingShingle |
VIP/VPAC Axis expression in immune-mediated inflammatory disorders: associated miRNA signatures Lamana Domínguez, Amalia VIP VPAC receptors MicroRNAs Immune-mediated inflammatory disorders Rheumatoid arthritis Spondyloarthritis Graves' disease Psoriasis Medicina Medicine |
| title_short |
VIP/VPAC Axis expression in immune-mediated inflammatory disorders: associated miRNA signatures |
| title_full |
VIP/VPAC Axis expression in immune-mediated inflammatory disorders: associated miRNA signatures |
| title_fullStr |
VIP/VPAC Axis expression in immune-mediated inflammatory disorders: associated miRNA signatures |
| title_full_unstemmed |
VIP/VPAC Axis expression in immune-mediated inflammatory disorders: associated miRNA signatures |
| title_sort |
VIP/VPAC Axis expression in immune-mediated inflammatory disorders: associated miRNA signatures |
| dc.creator.none.fl_str_mv |
Lamana Domínguez, Amalia Castro Vázquez, David Fuente Flores, Hortensia de la Triguero Martínez, Ana Martínez Hernández, Rebeca Revenga Martínez, Marcelino Villanueva Romero, Raúl Llamas Velasco, Mar Chicharro Manso, Pablo Juarranz Moratilla, Yasmina Marazuela Aspiroz, Mónica Sales Sanz, Marco García de Vicuña Pinedo, María del Rosario Tomero Muriel, Eva Gloria González Alvaro, Isidoro Martínez Mora, María del Carmen Pérez Gomáriz, Rosa María |
| author |
Lamana Domínguez, Amalia |
| author_facet |
Lamana Domínguez, Amalia Castro Vázquez, David Fuente Flores, Hortensia de la Triguero Martínez, Ana Martínez Hernández, Rebeca Revenga Martínez, Marcelino Villanueva Romero, Raúl Llamas Velasco, Mar Chicharro Manso, Pablo Juarranz Moratilla, Yasmina Marazuela Aspiroz, Mónica Sales Sanz, Marco García de Vicuña Pinedo, María del Rosario Tomero Muriel, Eva Gloria González Alvaro, Isidoro Martínez Mora, María del Carmen Pérez Gomáriz, Rosa María |
| author_role |
author |
| author2 |
Castro Vázquez, David Fuente Flores, Hortensia de la Triguero Martínez, Ana Martínez Hernández, Rebeca Revenga Martínez, Marcelino Villanueva Romero, Raúl Llamas Velasco, Mar Chicharro Manso, Pablo Juarranz Moratilla, Yasmina Marazuela Aspiroz, Mónica Sales Sanz, Marco García de Vicuña Pinedo, María del Rosario Tomero Muriel, Eva Gloria González Alvaro, Isidoro Martínez Mora, María del Carmen Pérez Gomáriz, Rosa María |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
VIP VPAC receptors MicroRNAs Immune-mediated inflammatory disorders Rheumatoid arthritis Spondyloarthritis Graves' disease Psoriasis Medicina Medicine |
| topic |
VIP VPAC receptors MicroRNAs Immune-mediated inflammatory disorders Rheumatoid arthritis Spondyloarthritis Graves' disease Psoriasis Medicina Medicine |
| description |
17 p. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022-08-02 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 NA http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10017/69304 https://dx.doi.org/10.3390/ijms23158578 35955723 |
| url |
http://hdl.handle.net/10017/69304 https://dx.doi.org/10.3390/ijms23158578 |
| identifier_str_mv |
35955723 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
ISCIII Not available RD21%2F0002%2F004 Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Not available RD16%2F0012%2F0008%2F004 Red de Investigación en Inflamación y Enfermedades Reumáticas (RIER) ISCIII Not available PI17%2F00027 EJE VIP ISCIII Not available PI20%2F00078 MECANISMOS REGULADORES DE LA EXPRESION, SEÑALIZACION Y FUNCION DE LOS RECEPTORES VPAC PARA VALIDAR SU APLICACION CLINICA EN ENFERMEDADES INFLAMATORIAS ISCIII Not available PI19-00584 INTEGROMICAS EN ENFERMEDADES TIROIDEAS AUTOINMUNES: MIRNOMA, TRANSCRIPTOMA Y ANALISIS DE CELULA INDIVIDUAL PARA CARACTERIZAR NUEVAS APROXIMACIONES CLINICAS Y VIAS DE SUSCEPTIBILIDAD EN ETAI ISCIII Not available PI21%2F01583 ESTUDIO INTEGRATIVO DE LA INFLAMACION SISTEMICA EN DERMATITIS ATOPICA E HIDRADENITIS SUPURATIVA Y SU ASOCIACIÓN CON LA ENFERMEDAD CARDIOVASCULAR Comunidad de Madrid http://dx.doi.org/10.13039/100012818 TIRONET2-CM B2017%2FBMD-3724 |
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open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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