A physical mechanism of TANGO1-mediated bulky cargo export

Copyright Raote et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

Detalles Bibliográficos
Autores: Raote, Ishier, Chabanon, Morgan, Walani, Nikhil, Arroyo Balaguer, Marino|||0000-0003-1647-940X, Garcia-Parajo, Maria F., Malhotra, Vivek, Campelo Aubarell, Felix
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/340361
Acceso en línea:https://hdl.handle.net/2117/340361
https://dx.doi.org/10.7554/eLife.59426
Access Level:acceso abierto
Palabra clave:Fluid mechanics
Mecànica de fluids
Classificació AMS::76 Fluid mechanics::76Z Biological fluid mechanics
Àrees temàtiques de la UPC::Matemàtiques i estadística::Matemàtica aplicada a les ciències
id ES_35c32a1ac5176cbe9abf64a2e5fb49b2
oai_identifier_str oai:upcommons.upc.edu:2117/340361
network_acronym_str ES
network_name_str España
repository_id_str
spelling A physical mechanism of TANGO1-mediated bulky cargo exportRaote, IshierChabanon, MorganWalani, NikhilArroyo Balaguer, Marino|||0000-0003-1647-940XGarcia-Parajo, Maria F.Malhotra, VivekCampelo Aubarell, FelixFluid mechanicsMecànica de fluidsClassificació AMS::76 Fluid mechanics::76Z Biological fluid mechanicsÀrees temàtiques de la UPC::Matemàtiques i estadística::Matemàtica aplicada a les ciènciesCopyright Raote et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.The endoplasmic reticulum (ER)-resident protein TANGO1 assembles into a ring around ER exit sites (ERES), and links procollagens in the ER lumen to COPII machinery, tethers, and ER-Golgi intermediate compartment (ERGIC) in the cytoplasm (Raote et al., 2018). Here, we present a theoretical approach to investigate the physical mechanisms of TANGO1 ring assembly and how COPII polymerization, membrane tension, and force facilitate the formation of a transport intermediate for procollagen export. Our results indicate that a TANGO1 ring, by acting as a linactant, stabilizes the open neck of a nascent COPII bud. Elongation of such a bud into a transport intermediate commensurate with bulky procollagens is then facilitated by two complementary mechanisms: (i) by relieving membrane tension, possibly by TANGO1-mediated fusion of retrograde ERGIC membranes and (ii) by force application. Altogether, our theoretical approach identifies key biophysical events in TANGO1-driven procollagen export.Peer Reviewed20202020-11-1020212021-02-23journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/340361https://dx.doi.org/10.7554/eLife.59426reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/3403612026-05-27T15:37:01Z
dc.title.none.fl_str_mv A physical mechanism of TANGO1-mediated bulky cargo export
title A physical mechanism of TANGO1-mediated bulky cargo export
spellingShingle A physical mechanism of TANGO1-mediated bulky cargo export
Raote, Ishier
Fluid mechanics
Mecànica de fluids
Classificació AMS::76 Fluid mechanics::76Z Biological fluid mechanics
Àrees temàtiques de la UPC::Matemàtiques i estadística::Matemàtica aplicada a les ciències
title_short A physical mechanism of TANGO1-mediated bulky cargo export
title_full A physical mechanism of TANGO1-mediated bulky cargo export
title_fullStr A physical mechanism of TANGO1-mediated bulky cargo export
title_full_unstemmed A physical mechanism of TANGO1-mediated bulky cargo export
title_sort A physical mechanism of TANGO1-mediated bulky cargo export
dc.creator.none.fl_str_mv Raote, Ishier
Chabanon, Morgan
Walani, Nikhil
Arroyo Balaguer, Marino|||0000-0003-1647-940X
Garcia-Parajo, Maria F.
Malhotra, Vivek
Campelo Aubarell, Felix
author Raote, Ishier
author_facet Raote, Ishier
Chabanon, Morgan
Walani, Nikhil
Arroyo Balaguer, Marino|||0000-0003-1647-940X
Garcia-Parajo, Maria F.
Malhotra, Vivek
Campelo Aubarell, Felix
author_role author
author2 Chabanon, Morgan
Walani, Nikhil
Arroyo Balaguer, Marino|||0000-0003-1647-940X
Garcia-Parajo, Maria F.
Malhotra, Vivek
Campelo Aubarell, Felix
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Fluid mechanics
Mecànica de fluids
Classificació AMS::76 Fluid mechanics::76Z Biological fluid mechanics
Àrees temàtiques de la UPC::Matemàtiques i estadística::Matemàtica aplicada a les ciències
topic Fluid mechanics
Mecànica de fluids
Classificació AMS::76 Fluid mechanics::76Z Biological fluid mechanics
Àrees temàtiques de la UPC::Matemàtiques i estadística::Matemàtica aplicada a les ciències
description Copyright Raote et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-11-10
2021
2021-02-23
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/340361
https://dx.doi.org/10.7554/eLife.59426
url https://hdl.handle.net/2117/340361
https://dx.doi.org/10.7554/eLife.59426
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405909220851712
score 15,198674

Similares en LA Referencia