Spanish Multicenter Megaprosthesis Study (MEGAPROT) on 816 Tumor Prostheses

(1) Background: The use of tumor megaprostheses faces challenges, but the published series are typically small and offer limited solutions. Our aim was to compile a large series; describe patient profiles and surgical techniques; analyze prosthetic survival identifying factors affecting survival; an...

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Detalles Bibliográficos
Autores: Pérez Muñoz, I., González Lizán, F., Sanz Pascual, M.d.C., Machado Granados, Pau, Peiró Ibañez, Ana M.|||0000-0002-2385-3749, Angulo Sánchez, M., de la Calva Ceinos, C., González Rojo, Paula|||0000-0002-8560-1715, Asua Mentxaka, L., Arteagoitia, I., Hernández González, N., Merino Pérez, J., Zarzuela, V.M., Puertas García-Sandoval, P.|||0000-0002-4652-4577, Valero Cifuentes, G., Valcárcel Díaz, A., Godoy Montijano, A., Fernández Serrano, F., González Acha, J., Esnaloa, P., Chaves Dorta, I., Coll Mesa, L., Baz Figueroa, C., Álvarez Garma, Á., Orce, A., Cebrián Parra, J.L., García Maroto, Roberto, Pablos Gonzalez, Oscar|||0000-0003-1951-0767, Maireles Pérez, Miriam, Fontalva Guerrero, María Luisa, Garcés Zarzalejo, C., Estellés Marcos de León, L.R., Gracia, Isidro|||0000-0002-9743-4184
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:320625
Acceso en línea:https://ddd.uab.cat/record/320625
https://dx.doi.org/urn:doi:10.3390/prosthesis7010002
Access Level:acceso abierto
Palabra clave:Megaprostheses
Tumor
Prostheses
Survival
Orthopedics
Fixation
Coating
Neoplasm
Osteosarcoma
Descripción
Sumario:(1) Background: The use of tumor megaprostheses faces challenges, but the published series are typically small and offer limited solutions. Our aim was to compile a large series; describe patient profiles and surgical techniques; analyze prosthetic survival identifying factors affecting survival; and provide a basis for future subanalyses. (2) Methods: This is a retrospective observational multicenter study that included patients with a tumor megaprosthesis in any anatomical location. Demographic, etiologic, and surgical variables were analyzed. Data on complications and survival were also collected. (3) Results: Our series includes a total of 816 prostheses (585 primary, 181 revision, and 50 second revision). The patients' mean age was 44.2 ± 20.8 years. Primary surgeries were performed on the femur (n = 404; 69.1%), tibia (n = 79; 13.5%), humerus (n = 74; 12.6%), pelvis (n = 20; 3.4%), and scapula (n = 4; 0.7%). Survival following primary surgery was 73.3% at 10 years. No statistically significant differences were found with respect to survival from primary surgery between males and females (p = 0.194), between the different etiologies (p = 0.540), or between the lower and the upper limb (p = 0.618). In contrast, statistically significant survival differences were found when the type of fixation was analyzed (p < 0.001). (4) Conclusions: This study analyzed one of the largest series of patients treated with tumor megaprostheses, demonstrating their acceptable survival and validating them as a treatment option for bone tumors.

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