Changes at small intestine induced by food-fish contaminated with ciguatoxins

Ciguateric syndrome is a food poisoning associated with the consumption of some species of fish that have accumulated ciguatoxins (CTXs) in their tissues. The effects of the syndrome occur with nervous imbalances which have been described for quite some time, and mentioned in sailing literature for...

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Autores: Hernández-López, Víctor, Reyes, Ricardo, García-Álvarez, Natalia, Real, Fernando, Díaz-Marrero, Ana Raquel, Fernández, José J.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/363961
Acceso en línea:http://hdl.handle.net/10261/363961
Access Level:acceso abierto
Palabra clave:Ciguatoxins
ciguatera
marine toxins
lymphocytic proliferation
paneth cells
fibrous lesions
small intestine
ciguatoxin
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spelling Changes at small intestine induced by food-fish contaminated with ciguatoxinsHernández-López, VíctorReyes, RicardoGarcía-Álvarez, NataliaReal, FernandoDíaz-Marrero, Ana RaquelFernández, José J.Ciguatoxinsciguateramarine toxinslymphocytic proliferationpaneth cellsfibrous lesionssmall intestineciguatoxinCiguateric syndrome is a food poisoning associated with the consumption of some species of fish that have accumulated ciguatoxins (CTXs) in their tissues. The effects of the syndrome occur with nervous imbalances which have been described for quite some time, and mentioned in sailing literature for centuries. In the last decade, research has been focused on the implementation of analytical methods for toxin identification and the study of action modes of CTXs to design effective treatments. However, an important aspect is to determine the damage that CTXs caused in the organs of affected individuals. In this work, the damages observed in tissues of mice, mainly in the small intestine, were analyzed. The animals were fed with CTX-contaminated fish muscle at concentrations 10-times below the median lethal dose (LD50) for 10 weeks. The analysis of tissues derived from the oral treatment resulted in an increased occurrence of Paneth cells, presence of lymphoid tissue infiltrating the mucosa and fibrous lesions in the mucosal layer of the small intestine. A decreasing weight in animals fed with toxic muscle was observed.This research was funded by projects PID2019–109476RB-C21 (BIOALGRI) (Spanish Ministry of Science), Madrid, Spain; and Government of the Canary Islands (ProID 2020010123), and PROMOTUR Turismo de Canarias (Actuaciones de Cohesión de Destino - Canarias Ecoínsulas II), and specifically the project "Islas Canarias, naturaleza marina singular: Salud y bienestar”.Peer reviewedElsevier BVMinisterio de Ciencia e Innovación (España)Gobierno de CanariasReyes, Ricardo [0000-0002-1765-3257]García-Álvarez, Natalia [0000-0001-5027-3072]Díaz-Marrero, Ana Raquel [0000-0002-8886-7519]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/363961reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-109476RB-C21https://doi.org/10.1016/j.ecoenv.2024.116741Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3639612026-05-22T06:33:51Z
dc.title.none.fl_str_mv Changes at small intestine induced by food-fish contaminated with ciguatoxins
title Changes at small intestine induced by food-fish contaminated with ciguatoxins
spellingShingle Changes at small intestine induced by food-fish contaminated with ciguatoxins
Hernández-López, Víctor
Ciguatoxins
ciguatera
marine toxins
lymphocytic proliferation
paneth cells
fibrous lesions
small intestine
ciguatoxin
title_short Changes at small intestine induced by food-fish contaminated with ciguatoxins
title_full Changes at small intestine induced by food-fish contaminated with ciguatoxins
title_fullStr Changes at small intestine induced by food-fish contaminated with ciguatoxins
title_full_unstemmed Changes at small intestine induced by food-fish contaminated with ciguatoxins
title_sort Changes at small intestine induced by food-fish contaminated with ciguatoxins
dc.creator.none.fl_str_mv Hernández-López, Víctor
Reyes, Ricardo
García-Álvarez, Natalia
Real, Fernando
Díaz-Marrero, Ana Raquel
Fernández, José J.
author Hernández-López, Víctor
author_facet Hernández-López, Víctor
Reyes, Ricardo
García-Álvarez, Natalia
Real, Fernando
Díaz-Marrero, Ana Raquel
Fernández, José J.
author_role author
author2 Reyes, Ricardo
García-Álvarez, Natalia
Real, Fernando
Díaz-Marrero, Ana Raquel
Fernández, José J.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Gobierno de Canarias
Reyes, Ricardo [0000-0002-1765-3257]
García-Álvarez, Natalia [0000-0001-5027-3072]
Díaz-Marrero, Ana Raquel [0000-0002-8886-7519]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Ciguatoxins
ciguatera
marine toxins
lymphocytic proliferation
paneth cells
fibrous lesions
small intestine
ciguatoxin
topic Ciguatoxins
ciguatera
marine toxins
lymphocytic proliferation
paneth cells
fibrous lesions
small intestine
ciguatoxin
description Ciguateric syndrome is a food poisoning associated with the consumption of some species of fish that have accumulated ciguatoxins (CTXs) in their tissues. The effects of the syndrome occur with nervous imbalances which have been described for quite some time, and mentioned in sailing literature for centuries. In the last decade, research has been focused on the implementation of analytical methods for toxin identification and the study of action modes of CTXs to design effective treatments. However, an important aspect is to determine the damage that CTXs caused in the organs of affected individuals. In this work, the damages observed in tissues of mice, mainly in the small intestine, were analyzed. The animals were fed with CTX-contaminated fish muscle at concentrations 10-times below the median lethal dose (LD50) for 10 weeks. The analysis of tissues derived from the oral treatment resulted in an increased occurrence of Paneth cells, presence of lymphoid tissue infiltrating the mucosa and fibrous lesions in the mucosal layer of the small intestine. A decreasing weight in animals fed with toxic muscle was observed.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/363961
url http://hdl.handle.net/10261/363961
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-109476RB-C21
https://doi.org/10.1016/j.ecoenv.2024.116741
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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