Neuroprotective properties of queen bee acid by autophagy induction.
Autophagy is a conserved intracellular catabolic pathway that removes cytoplasmic components to contribute to neuronal homeostasis. Accumulating evidence has increasingly shown that the induction of autophagy improves neuronal health and extends longevity in several animal models. Therefore, there i...
| Autores: | , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Recursos: | INCLIVA |
| Repositorio: | r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA |
| OAI Identifier: | oai:incliva.fundanetsuite.com:p15941 |
| Acesso em linha: | https://incliva.portalinvestigacion.com/publicaciones/15941 |
| Access Level: | acceso abierto |
| Palavra-chave: | Autophagy Longevity Neurodegeneration Parkinson’s disease QBA SIRT1 |
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Neuroprotective properties of queen bee acid by autophagy induction.Martínez-Chacón GParedes-Barquero MYakhine-Diop SMSUribe-Carretero EBargiela ASabater-Arcis MMorales-García JAlarcón-Gil JAlegre-Cortés ECanales-Cortés SRodríguez-Arribas MCamello PJPedro JMBPerez-Castillo AArtero RGonzalez-Polo RAFuentes JMNiso-Santano MAutophagyLongevityNeurodegenerationParkinson’s diseaseQBASIRT1Autophagy is a conserved intracellular catabolic pathway that removes cytoplasmic components to contribute to neuronal homeostasis. Accumulating evidence has increasingly shown that the induction of autophagy improves neuronal health and extends longevity in several animal models. Therefore, there is a great interest in the identification of effective autophagy enhancers with potential nutraceutical or pharmaceutical properties to ameliorate age-related diseases, such as neurodegenerative disorders, and/or promote longevity. Queen bee acid (QBA, 10-hydroxy-2-decenoic acid) is the major fatty acid component of, and is found exclusively in, royal jelly, which has beneficial properties for human health. It is reported that QBA has antitumor, anti-inflammatory, and antibacterial activities and promotes neurogenesis and neuronal health; however, the mechanism by which QBA exerts these effects has not been fully elucidated. The present study investigated the role of the autophagic process in the protective effect of QBA. We found that QBA is a novel autophagy inducer that triggers autophagy in various neuronal cell lines and mouse and fly models. The beclin-1 (BECN1) and mTOR pathways participate in the regulation of QBA-induced autophagy. Moreover, our results showed that QBA stimulates sirtuin 1 (SIRT1), which promotes autophagy by the deacetylation of critical ATG proteins. Finally, QBA-mediated autophagy promotes neuroprotection in Parkinson's disease in vitro and in a mouse model and extends the lifespan of Drosophila melanogaster. This study provides detailed evidences showing that autophagy induction plays a critical role in the beneficial health effects of QBA.SPRINGER2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/15941CELL BIOLOGY AND TOXICOLOGYISSN: 07422091ISSNe: 15736822reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p159412026-06-07T16:35:31Z |
| dc.title.none.fl_str_mv |
Neuroprotective properties of queen bee acid by autophagy induction. |
| title |
Neuroprotective properties of queen bee acid by autophagy induction. |
| spellingShingle |
Neuroprotective properties of queen bee acid by autophagy induction. Martínez-Chacón G Autophagy Longevity Neurodegeneration Parkinson’s disease QBA SIRT1 |
| title_short |
Neuroprotective properties of queen bee acid by autophagy induction. |
| title_full |
Neuroprotective properties of queen bee acid by autophagy induction. |
| title_fullStr |
Neuroprotective properties of queen bee acid by autophagy induction. |
| title_full_unstemmed |
Neuroprotective properties of queen bee acid by autophagy induction. |
| title_sort |
Neuroprotective properties of queen bee acid by autophagy induction. |
| dc.creator.none.fl_str_mv |
Martínez-Chacón G Paredes-Barquero M Yakhine-Diop SMS Uribe-Carretero E Bargiela A Sabater-Arcis M Morales-García J Alarcón-Gil J Alegre-Cortés E Canales-Cortés S Rodríguez-Arribas M Camello PJ Pedro JMB Perez-Castillo A Artero R Gonzalez-Polo RA Fuentes JM Niso-Santano M |
| author |
Martínez-Chacón G |
| author_facet |
Martínez-Chacón G Paredes-Barquero M Yakhine-Diop SMS Uribe-Carretero E Bargiela A Sabater-Arcis M Morales-García J Alarcón-Gil J Alegre-Cortés E Canales-Cortés S Rodríguez-Arribas M Camello PJ Pedro JMB Perez-Castillo A Artero R Gonzalez-Polo RA Fuentes JM Niso-Santano M |
| author_role |
author |
| author2 |
Paredes-Barquero M Yakhine-Diop SMS Uribe-Carretero E Bargiela A Sabater-Arcis M Morales-García J Alarcón-Gil J Alegre-Cortés E Canales-Cortés S Rodríguez-Arribas M Camello PJ Pedro JMB Perez-Castillo A Artero R Gonzalez-Polo RA Fuentes JM Niso-Santano M |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Autophagy Longevity Neurodegeneration Parkinson’s disease QBA SIRT1 |
| topic |
Autophagy Longevity Neurodegeneration Parkinson’s disease QBA SIRT1 |
| description |
Autophagy is a conserved intracellular catabolic pathway that removes cytoplasmic components to contribute to neuronal homeostasis. Accumulating evidence has increasingly shown that the induction of autophagy improves neuronal health and extends longevity in several animal models. Therefore, there is a great interest in the identification of effective autophagy enhancers with potential nutraceutical or pharmaceutical properties to ameliorate age-related diseases, such as neurodegenerative disorders, and/or promote longevity. Queen bee acid (QBA, 10-hydroxy-2-decenoic acid) is the major fatty acid component of, and is found exclusively in, royal jelly, which has beneficial properties for human health. It is reported that QBA has antitumor, anti-inflammatory, and antibacterial activities and promotes neurogenesis and neuronal health; however, the mechanism by which QBA exerts these effects has not been fully elucidated. The present study investigated the role of the autophagic process in the protective effect of QBA. We found that QBA is a novel autophagy inducer that triggers autophagy in various neuronal cell lines and mouse and fly models. The beclin-1 (BECN1) and mTOR pathways participate in the regulation of QBA-induced autophagy. Moreover, our results showed that QBA stimulates sirtuin 1 (SIRT1), which promotes autophagy by the deacetylation of critical ATG proteins. Finally, QBA-mediated autophagy promotes neuroprotection in Parkinson's disease in vitro and in a mouse model and extends the lifespan of Drosophila melanogaster. This study provides detailed evidences showing that autophagy induction plays a critical role in the beneficial health effects of QBA. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://incliva.portalinvestigacion.com/publicaciones/15941 |
| url |
https://incliva.portalinvestigacion.com/publicaciones/15941 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
SPRINGER |
| publisher.none.fl_str_mv |
SPRINGER |
| dc.source.none.fl_str_mv |
CELL BIOLOGY AND TOXICOLOGY ISSN: 07422091 ISSNe: 15736822 reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA instname:INCLIVA |
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INCLIVA |
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r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA |
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r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA |
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|
| repository.mail.fl_str_mv |
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1869405907466584064 |
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15,812429 |