Label-free plasmonic biosensors for point-of-care diagnostics

Introduction: Optical biosensors, particularly those based on nanoplasmonics technology, have emerged in recent decades as a potential solution for disease diagnostics and therapy follow-up at the point-of-care (POC). These biosensor platforms could overcome some of the challenges faced in conventio...

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Autores: Soler Aznar, Maria|||0000-0001-7232-2277, Huertas, César S.|||0000-0002-3100-4034, Lechuga, Laura M|||0000-0001-5187-5358
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:205464
Acceso en línea:https://ddd.uab.cat/record/205464
https://dx.doi.org/urn:doi:10.1080/14737159.2019.1554435
Access Level:acceso abierto
Palabra clave:Nanoplasmonic biosensors
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spelling Label-free plasmonic biosensors for point-of-care diagnosticsa reviewOptical biosensors for point-of-care diagnosticsSoler Aznar, Maria|||0000-0001-7232-2277Huertas, César S.|||0000-0002-3100-4034Lechuga, Laura M|||0000-0001-5187-5358Nanoplasmonic biosensorsIntroduction: Optical biosensors, particularly those based on nanoplasmonics technology, have emerged in recent decades as a potential solution for disease diagnostics and therapy follow-up at the point-of-care (POC). These biosensor platforms could overcome some of the challenges faced in conventional diagnosis techniques offering label-free assays with immediate results and employing small and user-friendly devices. Areas covered: In this review, we will provide a critical overview of the recent advances in the development of nanoplasmonic biosensors for the POC diagnostics. We focus on those systems with demonstrated capabilities for integration in portable platforms, highlighting some of the most relevant diagnostics applications targeting proteins, nucleic acids, and cells as disease biomarkers. Expert commentary: Despite the attractive features of label-free nanoplasmonic sensors in terms of miniaturization and analytical robustness, the route toward an effective clinical implementation involves the integration of fully automated microfluidic systems for sample processing and analysis, and the optimization of surface biofunctionalization procedures. Additionally, the development of multiplexed sensors for high-throughput analysis and including specific neoantigens and novel biomarkers in detection panels will provide the means for delivering a powerful analytical technology for an accurate and improved medical diagnosis. 22018-01-0120182018-01-01Articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/205464https://dx.doi.org/urn:doi:10.1080/14737159.2019.1554435reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 SEV-2013-0295open accesshttp://purl.org/coar/access_right/c_abf2Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.https://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2054642026-06-06T12:50:31Z
dc.title.none.fl_str_mv Label-free plasmonic biosensors for point-of-care diagnostics
a review
Optical biosensors for point-of-care diagnostics
title Label-free plasmonic biosensors for point-of-care diagnostics
spellingShingle Label-free plasmonic biosensors for point-of-care diagnostics
Soler Aznar, Maria|||0000-0001-7232-2277
Nanoplasmonic biosensors
title_short Label-free plasmonic biosensors for point-of-care diagnostics
title_full Label-free plasmonic biosensors for point-of-care diagnostics
title_fullStr Label-free plasmonic biosensors for point-of-care diagnostics
title_full_unstemmed Label-free plasmonic biosensors for point-of-care diagnostics
title_sort Label-free plasmonic biosensors for point-of-care diagnostics
dc.creator.none.fl_str_mv Soler Aznar, Maria|||0000-0001-7232-2277
Huertas, César S.|||0000-0002-3100-4034
Lechuga, Laura M|||0000-0001-5187-5358
author Soler Aznar, Maria|||0000-0001-7232-2277
author_facet Soler Aznar, Maria|||0000-0001-7232-2277
Huertas, César S.|||0000-0002-3100-4034
Lechuga, Laura M|||0000-0001-5187-5358
author_role author
author2 Huertas, César S.|||0000-0002-3100-4034
Lechuga, Laura M|||0000-0001-5187-5358
author2_role author
author
dc.subject.none.fl_str_mv Nanoplasmonic biosensors
topic Nanoplasmonic biosensors
description Introduction: Optical biosensors, particularly those based on nanoplasmonics technology, have emerged in recent decades as a potential solution for disease diagnostics and therapy follow-up at the point-of-care (POC). These biosensor platforms could overcome some of the challenges faced in conventional diagnosis techniques offering label-free assays with immediate results and employing small and user-friendly devices. Areas covered: In this review, we will provide a critical overview of the recent advances in the development of nanoplasmonic biosensors for the POC diagnostics. We focus on those systems with demonstrated capabilities for integration in portable platforms, highlighting some of the most relevant diagnostics applications targeting proteins, nucleic acids, and cells as disease biomarkers. Expert commentary: Despite the attractive features of label-free nanoplasmonic sensors in terms of miniaturization and analytical robustness, the route toward an effective clinical implementation involves the integration of fully automated microfluidic systems for sample processing and analysis, and the optimization of surface biofunctionalization procedures. Additionally, the development of multiplexed sensors for high-throughput analysis and including specific neoantigens and novel biomarkers in detection panels will provide the means for delivering a powerful analytical technology for an accurate and improved medical diagnosis.
publishDate 2018
dc.date.none.fl_str_mv 2
2018-01-01
2018
2018-01-01
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http://purl.org/coar/resource_type/c_6501
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https://dx.doi.org/urn:doi:10.1080/14737159.2019.1554435
url https://ddd.uab.cat/record/205464
https://dx.doi.org/urn:doi:10.1080/14737159.2019.1554435
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 SEV-2013-0295
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
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dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
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eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
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