Procalcitonin and C-reactive protein to rule out early bacterial coinfection in COVID-19 critically ill patients
Although the prevalence of community-acquired respiratory bacterial coinfection upon hospital admission in patients with coronavirus disease 2019 (COVID-19) has been reported to be < 5%, almost three-quarters of patients received antibiotics. We aim to investigate whether procalcitonin (PCT) or C...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2023 |
| País: | España |
| Recursos: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:290196 |
| Acesso em linha: | https://ddd.uab.cat/record/290196 https://dx.doi.org/urn:doi:10.1007/s00134-023-07161-1 |
| Access Level: | acceso abierto |
| Palavra-chave: | Bacterial coinfection COVID-19 Critically ill C-reactive protein Intensive care Procalcitonin |
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ES_355756f0f942e2c4c7413613201badba |
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| oai_identifier_str |
oai:ddd.uab.cat:290196 |
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España |
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| dc.title.none.fl_str_mv |
Procalcitonin and C-reactive protein to rule out early bacterial coinfection in COVID-19 critically ill patients |
| title |
Procalcitonin and C-reactive protein to rule out early bacterial coinfection in COVID-19 critically ill patients |
| spellingShingle |
Procalcitonin and C-reactive protein to rule out early bacterial coinfection in COVID-19 critically ill patients Galli, Flavia Bacterial coinfection COVID-19 Critically ill C-reactive protein Intensive care Procalcitonin |
| title_short |
Procalcitonin and C-reactive protein to rule out early bacterial coinfection in COVID-19 critically ill patients |
| title_full |
Procalcitonin and C-reactive protein to rule out early bacterial coinfection in COVID-19 critically ill patients |
| title_fullStr |
Procalcitonin and C-reactive protein to rule out early bacterial coinfection in COVID-19 critically ill patients |
| title_full_unstemmed |
Procalcitonin and C-reactive protein to rule out early bacterial coinfection in COVID-19 critically ill patients |
| title_sort |
Procalcitonin and C-reactive protein to rule out early bacterial coinfection in COVID-19 critically ill patients |
| dc.creator.none.fl_str_mv |
Galli, Flavia Bindo, Francesco Motos, Ana|||0000-0002-3757-1232 Fernández Barat, Laia|||0000-0001-7528-9636 Barbeta, Enric|||0000-0001-9725-4100 Gabarrús, Albert|||0000-0003-3492-1310 Ceccato, Adrian|||0000-0001-9454-062X Bermejo-Martin, Jesus F.|||0000-0002-7998-6268 Ferrer, Ricard|||0000-0002-4859-4747 Riera del Brio, Jordi|||0000-0002-1738-4448 Peñuelas, Oscar|||0000-0003-1484-3933 Lorente, José Ángel Gonzalo Calvo, David de|||0000-0003-2240-3532 Menéndez, Rosario González, Jéssica Misuraca, Sofia Palomeque, Andrea Amaya-Villar, Rosario Añón, José Manuel Balan Mariño, Ana Barberà, Carme Barberán, José Blandino Ortiz, Aaron|||0000-0002-3184-6418 Bustamante-Munguira, Elena Caballero, Jesús|||0000-0001-9005-9687 Cantón-Bulnes, María Luisa Carbajales Pérez, Cristina Carbonell, Nieves|||0000-0002-9149-0310 Catalán-González, Mercedes de Frutos, Raul Franco, Nieves Galbán, Cristóbal Lopez Lago, Ana Gumucio-Sanguino, Víctor D. de la Torre, Maria Del Carmen Díaz Santos, Emilio|||0000-0003-3637-3821 Estella, Ángel|||0000-0003-0665-557X Gallego Curto, Elena García-Garmendia, José Luis Gómez, José Manuel Huerta, Arturo|||0000-0002-6191-4143 Jorge García, Ruth Noemí Loza-Vázquez, Ana Marin-Corral, Judith|||0000-0003-1320-4427 Martin Delgado, María Cruz Martínez de la Gándara, Amalia Martínez Varela, Ignacio Lopez Messa, Juan M. Albaiceta, Guillermo Nieto, Maite Novo, Mariana Andrea Peñasco, Yhivian Pérez-García, Felipe|||0000-0002-4885-4334 Pozo-Laderas, Juan Carlos Ricart, Pilar|||0000-0003-0067-9132 Sagredo, Victor Sánchez Miralles, Ángel Sancho Chinesta, Susana Roche-Campo, Ferran Socias, Lorenzo Solé-Violan, Jordi Suarez-Sipmann, Fernando|||0000-0002-7412-2970 Tamayo Lomas, Luis Trenado, José Úbeda, Alejandro Valdivia, Luis Jorge Vidal, Pablo Boado Varela, Maria Victoria Rodríguez, Alejandro Antonelli, Massimo|||0000-0003-3007-1670 Blasi, Francesco|||0000-0002-2285-9970 Barbé, Ferran|||0000-0002-2340-8928 Torres, Antoni|||0000-0002-8643-2167 |
| author |
Galli, Flavia |
| author_facet |
Galli, Flavia Bindo, Francesco Motos, Ana|||0000-0002-3757-1232 Fernández Barat, Laia|||0000-0001-7528-9636 Barbeta, Enric|||0000-0001-9725-4100 Gabarrús, Albert|||0000-0003-3492-1310 Ceccato, Adrian|||0000-0001-9454-062X Bermejo-Martin, Jesus F.|||0000-0002-7998-6268 Ferrer, Ricard|||0000-0002-4859-4747 Riera del Brio, Jordi|||0000-0002-1738-4448 Peñuelas, Oscar|||0000-0003-1484-3933 Lorente, José Ángel Gonzalo Calvo, David de|||0000-0003-2240-3532 Menéndez, Rosario González, Jéssica Misuraca, Sofia Palomeque, Andrea Amaya-Villar, Rosario Añón, José Manuel Balan Mariño, Ana Barberà, Carme Barberán, José Blandino Ortiz, Aaron|||0000-0002-3184-6418 Bustamante-Munguira, Elena Caballero, Jesús|||0000-0001-9005-9687 Cantón-Bulnes, María Luisa Carbajales Pérez, Cristina Carbonell, Nieves|||0000-0002-9149-0310 Catalán-González, Mercedes de Frutos, Raul Franco, Nieves Galbán, Cristóbal Lopez Lago, Ana Gumucio-Sanguino, Víctor D. de la Torre, Maria Del Carmen Díaz Santos, Emilio|||0000-0003-3637-3821 Estella, Ángel|||0000-0003-0665-557X Gallego Curto, Elena García-Garmendia, José Luis Gómez, José Manuel Huerta, Arturo|||0000-0002-6191-4143 Jorge García, Ruth Noemí Loza-Vázquez, Ana Marin-Corral, Judith|||0000-0003-1320-4427 Martin Delgado, María Cruz Martínez de la Gándara, Amalia Martínez Varela, Ignacio Lopez Messa, Juan M. Albaiceta, Guillermo Nieto, Maite Novo, Mariana Andrea Peñasco, Yhivian Pérez-García, Felipe|||0000-0002-4885-4334 Pozo-Laderas, Juan Carlos Ricart, Pilar|||0000-0003-0067-9132 Sagredo, Victor Sánchez Miralles, Ángel Sancho Chinesta, Susana Roche-Campo, Ferran Socias, Lorenzo Solé-Violan, Jordi Suarez-Sipmann, Fernando|||0000-0002-7412-2970 Tamayo Lomas, Luis Trenado, José Úbeda, Alejandro Valdivia, Luis Jorge Vidal, Pablo Boado Varela, Maria Victoria Rodríguez, Alejandro Antonelli, Massimo|||0000-0003-3007-1670 Blasi, Francesco|||0000-0002-2285-9970 Barbé, Ferran|||0000-0002-2340-8928 Torres, Antoni|||0000-0002-8643-2167 |
| author_role |
author |
| author2 |
Bindo, Francesco Motos, Ana|||0000-0002-3757-1232 Fernández Barat, Laia|||0000-0001-7528-9636 Barbeta, Enric|||0000-0001-9725-4100 Gabarrús, Albert|||0000-0003-3492-1310 Ceccato, Adrian|||0000-0001-9454-062X Bermejo-Martin, Jesus F.|||0000-0002-7998-6268 Ferrer, Ricard|||0000-0002-4859-4747 Riera del Brio, Jordi|||0000-0002-1738-4448 Peñuelas, Oscar|||0000-0003-1484-3933 Lorente, José Ángel Gonzalo Calvo, David de|||0000-0003-2240-3532 Menéndez, Rosario González, Jéssica Misuraca, Sofia Palomeque, Andrea Amaya-Villar, Rosario Añón, José Manuel Balan Mariño, Ana Barberà, Carme Barberán, José Blandino Ortiz, Aaron|||0000-0002-3184-6418 Bustamante-Munguira, Elena Caballero, Jesús|||0000-0001-9005-9687 Cantón-Bulnes, María Luisa Carbajales Pérez, Cristina Carbonell, Nieves|||0000-0002-9149-0310 Catalán-González, Mercedes de Frutos, Raul Franco, Nieves Galbán, Cristóbal Lopez Lago, Ana Gumucio-Sanguino, Víctor D. de la Torre, Maria Del Carmen Díaz Santos, Emilio|||0000-0003-3637-3821 Estella, Ángel|||0000-0003-0665-557X Gallego Curto, Elena García-Garmendia, José Luis Gómez, José Manuel Huerta, Arturo|||0000-0002-6191-4143 Jorge García, Ruth Noemí Loza-Vázquez, Ana Marin-Corral, Judith|||0000-0003-1320-4427 Martin Delgado, María Cruz Martínez de la Gándara, Amalia Martínez Varela, Ignacio Lopez Messa, Juan M. Albaiceta, Guillermo Nieto, Maite Novo, Mariana Andrea Peñasco, Yhivian Pérez-García, Felipe|||0000-0002-4885-4334 Pozo-Laderas, Juan Carlos Ricart, Pilar|||0000-0003-0067-9132 Sagredo, Victor Sánchez Miralles, Ángel Sancho Chinesta, Susana Roche-Campo, Ferran Socias, Lorenzo Solé-Violan, Jordi Suarez-Sipmann, Fernando|||0000-0002-7412-2970 Tamayo Lomas, Luis Trenado, José Úbeda, Alejandro Valdivia, Luis Jorge Vidal, Pablo Boado Varela, Maria Victoria Rodríguez, Alejandro Antonelli, Massimo|||0000-0003-3007-1670 Blasi, Francesco|||0000-0002-2285-9970 Barbé, Ferran|||0000-0002-2340-8928 Torres, Antoni|||0000-0002-8643-2167 |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Bacterial coinfection COVID-19 Critically ill C-reactive protein Intensive care Procalcitonin |
| topic |
Bacterial coinfection COVID-19 Critically ill C-reactive protein Intensive care Procalcitonin |
| description |
Although the prevalence of community-acquired respiratory bacterial coinfection upon hospital admission in patients with coronavirus disease 2019 (COVID-19) has been reported to be < 5%, almost three-quarters of patients received antibiotics. We aim to investigate whether procalcitonin (PCT) or C-reactive protein (CRP) upon admission could be helpful biomarkers to identify bacterial coinfection among patients with COVID-19 pneumonia. We carried out a multicentre, observational cohort study including consecutive COVID-19 patients admitted to 55 Spanish intensive care units (ICUs). The primary outcome was to explore whether PCT or CRP serum levels upon hospital admission could predict bacterial coinfection among patients with COVID-19 pneumonia. The secondary outcome was the evaluation of their association with mortality. We also conducted subgroups analyses in higher risk profile populations. Between 5 February 2020 and 21 December 2021, 4076 patients were included, 133 (3%) of whom presented bacterial coinfection. PCT and CRP had low area under curve (AUC) scores at the receiver operating characteristic (ROC) curve analysis [0.57 (95% confidence interval (CI) 0.51-0.61) and 0.6 (95% CI, 0.55-0.64), respectively], but high negative predictive values (NPV) [97.5% (95% CI 96.5-98.5) and 98.2% (95% CI 97.5-98.9) for PCT and CRP, respectively]. CRP alone was associated with bacterial coinfection (OR 2, 95% CI 1.25-3.19; p = 0.004). The overall 15, 30 and 90 days mortality had a higher trend in the bacterial coinfection group, but without significant difference. PCT ≥ 0.12 ng/mL was associated with higher 90 days mortality. Our study suggests that measurements of PCT and CRP, alone and at a single time point, are not useful for ruling in or out bacterial coinfection in viral pneumonia by COVID-19. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2 2023-01-01 2023 2023-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/290196 https://dx.doi.org/urn:doi:10.1007/s00134-023-07161-1 |
| url |
https://ddd.uab.cat/record/290196 https://dx.doi.org/urn:doi:10.1007/s00134-023-07161-1 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.source.none.fl_str_mv |
reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
| instname_str |
Universitat Autònoma de Barcelona |
| reponame_str |
Dipòsit Digital de Documents de la UAB |
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Dipòsit Digital de Documents de la UAB |
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|
| repository.mail.fl_str_mv |
|
| _version_ |
1869405875683196928 |
| spelling |
Procalcitonin and C-reactive protein to rule out early bacterial coinfection in COVID-19 critically ill patientsGalli, FlaviaBindo, FrancescoMotos, Ana|||0000-0002-3757-1232Fernández Barat, Laia|||0000-0001-7528-9636Barbeta, Enric|||0000-0001-9725-4100Gabarrús, Albert|||0000-0003-3492-1310Ceccato, Adrian|||0000-0001-9454-062XBermejo-Martin, Jesus F.|||0000-0002-7998-6268Ferrer, Ricard|||0000-0002-4859-4747Riera del Brio, Jordi|||0000-0002-1738-4448Peñuelas, Oscar|||0000-0003-1484-3933Lorente, José ÁngelGonzalo Calvo, David de|||0000-0003-2240-3532Menéndez, RosarioGonzález, JéssicaMisuraca, SofiaPalomeque, AndreaAmaya-Villar, RosarioAñón, José ManuelBalan Mariño, AnaBarberà, CarmeBarberán, JoséBlandino Ortiz, Aaron|||0000-0002-3184-6418Bustamante-Munguira, ElenaCaballero, Jesús|||0000-0001-9005-9687Cantón-Bulnes, María LuisaCarbajales Pérez, CristinaCarbonell, Nieves|||0000-0002-9149-0310Catalán-González, Mercedesde Frutos, RaulFranco, NievesGalbán, CristóbalLopez Lago, AnaGumucio-Sanguino, Víctor D.de la Torre, Maria Del CarmenDíaz Santos, Emilio|||0000-0003-3637-3821Estella, Ángel|||0000-0003-0665-557XGallego Curto, ElenaGarcía-Garmendia, José LuisGómez, José ManuelHuerta, Arturo|||0000-0002-6191-4143Jorge García, Ruth NoemíLoza-Vázquez, AnaMarin-Corral, Judith|||0000-0003-1320-4427Martin Delgado, María CruzMartínez de la Gándara, AmaliaMartínez Varela, IgnacioLopez Messa, JuanM. Albaiceta, GuillermoNieto, MaiteNovo, Mariana AndreaPeñasco, YhivianPérez-García, Felipe|||0000-0002-4885-4334Pozo-Laderas, Juan CarlosRicart, Pilar|||0000-0003-0067-9132Sagredo, VictorSánchez Miralles, ÁngelSancho Chinesta, SusanaRoche-Campo, FerranSocias, LorenzoSolé-Violan, JordiSuarez-Sipmann, Fernando|||0000-0002-7412-2970Tamayo Lomas, LuisTrenado, JoséÚbeda, AlejandroValdivia, Luis JorgeVidal, PabloBoado Varela, Maria VictoriaRodríguez, AlejandroAntonelli, Massimo|||0000-0003-3007-1670Blasi, Francesco|||0000-0002-2285-9970Barbé, Ferran|||0000-0002-2340-8928Torres, Antoni|||0000-0002-8643-2167Bacterial coinfectionCOVID-19Critically illC-reactive proteinIntensive careProcalcitoninAlthough the prevalence of community-acquired respiratory bacterial coinfection upon hospital admission in patients with coronavirus disease 2019 (COVID-19) has been reported to be < 5%, almost three-quarters of patients received antibiotics. We aim to investigate whether procalcitonin (PCT) or C-reactive protein (CRP) upon admission could be helpful biomarkers to identify bacterial coinfection among patients with COVID-19 pneumonia. We carried out a multicentre, observational cohort study including consecutive COVID-19 patients admitted to 55 Spanish intensive care units (ICUs). The primary outcome was to explore whether PCT or CRP serum levels upon hospital admission could predict bacterial coinfection among patients with COVID-19 pneumonia. The secondary outcome was the evaluation of their association with mortality. We also conducted subgroups analyses in higher risk profile populations. Between 5 February 2020 and 21 December 2021, 4076 patients were included, 133 (3%) of whom presented bacterial coinfection. PCT and CRP had low area under curve (AUC) scores at the receiver operating characteristic (ROC) curve analysis [0.57 (95% confidence interval (CI) 0.51-0.61) and 0.6 (95% CI, 0.55-0.64), respectively], but high negative predictive values (NPV) [97.5% (95% CI 96.5-98.5) and 98.2% (95% CI 97.5-98.9) for PCT and CRP, respectively]. CRP alone was associated with bacterial coinfection (OR 2, 95% CI 1.25-3.19; p = 0.004). The overall 15, 30 and 90 days mortality had a higher trend in the bacterial coinfection group, but without significant difference. PCT ≥ 0.12 ng/mL was associated with higher 90 days mortality. Our study suggests that measurements of PCT and CRP, alone and at a single time point, are not useful for ruling in or out bacterial coinfection in viral pneumonia by COVID-19.Universitat Autònoma de Barcelona 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/290196https://dx.doi.org/urn:doi:10.1007/s00134-023-07161-1reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2901962026-06-06T12:50:31Z |
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15,300724 |