Epidemiology of resistance to aminoglycosides and macrolidesin thermotolerant Campylobacter in livestock in Spain
Antimicrobial resistance is a major problem for the treatment of diseases caused by zoonotic bacteria such as thermotolerant Campylobacter (C. coli and C. jejuni). The mechanisms by which antimicrobial resistance spreads over bacterial populations, specially via horizontal gene transfer, can have br...
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| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2026 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/133720 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/133720 |
| Access Level: | acceso abierto |
| Palabra clave: | 636.09:615(043.2) Medicamentos (Veterinaria) Veterinary drugs Medicamentos 3109.08 Farmacología |
| Sumario: | Antimicrobial resistance is a major problem for the treatment of diseases caused by zoonotic bacteria such as thermotolerant Campylobacter (C. coli and C. jejuni). The mechanisms by which antimicrobial resistance spreads over bacterial populations, specially via horizontal gene transfer, can have broad consequences depending on the speed at which resistant phenotypes disseminate through food animal hosts, humans and the environment. Particularly relevant are genetic determinants capable of conferring resistance to three or more antimicrobial classes, making treatments more complicated when multi-drug resistant bacteria are involved. In the case of Campylobacter infections, aminoglycosides and macrolides are the two antimicrobial classes most commonly used to treat clinical cases, when this is necessary. This thesis is focused on the characterization of the distribution and genetic basis of coresistance mechanisms involving aminoglycosides and macrolides in Campylobacter that could explain possible ways of acquisition, maintenance and dissemination of these resistance phenotypes.. |
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