Epidemiological surveillance of Crimean-Congo haemorrhagic fever virus in the Iberian lynx (Lynx pardinus), 2010–2022

Crimean-Congo haemorrhagic fever virus (CCHFV) is a zoonotic pathogen whose main vector and reservoir are Hyalomma ticks. The recent emergence of the severe disease in humans caused by this virus in southwestern Europe has alerted sanitary authorities about its public health significance. This study...

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Autores: Sánchez-Sánchez, Marta, Caballero-Gómez, Javier, Contreras, Marinela, Moraga‑Fernández, Alberto, Muñoz-Hernández, Clara, Fernández-Verón, Isabel, Fischer, Kerstin, Bost, Caroline, Castro-Scholten, Sabrina, Baz-Flores, Sara, Rey, Teresa del, Nájera, Fernando, Montoya-Oliver, Ignacio, Salcedo, Javier, Fernández de Mera, Isabel G., García-Bocanegra, Ignacio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/407804
Acceso en línea:http://hdl.handle.net/10261/407804
Access Level:acceso abierto
Palabra clave:CCHFV
Iberian lynx
Epidemiology
Zoonosis
Ticks
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spelling Epidemiological surveillance of Crimean-Congo haemorrhagic fever virus in the Iberian lynx (Lynx pardinus), 2010–2022Sánchez-Sánchez, MartaCaballero-Gómez, JavierContreras, MarinelaMoraga‑Fernández, AlbertoMuñoz-Hernández, ClaraFernández-Verón, IsabelFischer, KerstinBost, CarolineCastro-Scholten, SabrinaBaz-Flores, SaraRey, Teresa delNájera, FernandoMontoya-Oliver, IgnacioSalcedo, JavierFernández de Mera, Isabel G.García-Bocanegra, IgnacioCCHFVIberian lynxEpidemiologyZoonosisTicksCrimean-Congo haemorrhagic fever virus (CCHFV) is a zoonotic pathogen whose main vector and reservoir are Hyalomma ticks. The recent emergence of the severe disease in humans caused by this virus in southwestern Europe has alerted sanitary authorities about its public health significance. This study was aimed to assess the role of the Iberian lynx (Lynx pardinus) in the epidemiology of CCHFV in the Iberian Peninsula. Of 554 lynxes tested, anti-CCHFV antibodies were detected in 66 animals (11.9 %; 95 % confidence intervals (CI): 9.2–14.6). Age was a risk factor associated with exposure to CCHFV in free-ranging lynxes. Additionally, 63 of the 554 animals were longitudinally surveyed, nine of them seroconverted during the study period. None of the 48 blood samples and 219 feeding ticks (mostly Rhipicephalus pusillus) were positive to CCHFV RNA. The results suggest an endemic, and widespread circulation of CCHFV, particularly in the free-ranging populations, confirming the susceptibility of the Iberian lynx to CCHFV, even though they may only play a limited role in the enzootic cycle of this virus.This research was also partially supported by the CIBER -Consorcio Centro de Investigación Biomédica en Red- (CB 2021/13/00083), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación and Unión Europea –NextGenerationEU. This study was partially supported by the Government of Castilla-La Mancha (JCCM, Spain), through project BPLY/19/180501/000321, and by the 2022-GRIN-34227 grant funded by the UCLM and FEDER. MSS was supported by PTA2022-022349-I financed by MCIN/AEI/10.13039/501100011033 and FSE+ and by JAE-PRE grant (JAEPR23054-Consejo Superior de Investigaciones Científicas). JCG was supported by the CIBER -Consorcio Centro de Investigación Biomédica en Red-(CB21/13/00083), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación and Unión Europea-NextGenerationEU. AMF was supported by Research Plan of University of Castilla-La Mancha, UCLM. IGFM is part of the CSIC's Global Health Plaform (PTI Salud Global).Peer reviewedElsevierInstituto de Salud Carlos IIIEuropean CommissionJunta de Comunidades de Castilla-La ManchaUniversidad de Castilla La ManchaMinisterio de Ciencia e Innovación (España)Agencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)Consejo Superior de Investigaciones Científicas (España)CSIC - Plataforma Temática Interdisciplinar del CSIC Salud Global (PTI Salud Global)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/407804reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PTA2022-022349-IThe underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.1016/j.vetmic.2025.110722https://doi.org/10.1016/j.vetmic.2025.110722Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4078042026-05-22T06:33:51Z
dc.title.none.fl_str_mv Epidemiological surveillance of Crimean-Congo haemorrhagic fever virus in the Iberian lynx (Lynx pardinus), 2010–2022
title Epidemiological surveillance of Crimean-Congo haemorrhagic fever virus in the Iberian lynx (Lynx pardinus), 2010–2022
spellingShingle Epidemiological surveillance of Crimean-Congo haemorrhagic fever virus in the Iberian lynx (Lynx pardinus), 2010–2022
Sánchez-Sánchez, Marta
CCHFV
Iberian lynx
Epidemiology
Zoonosis
Ticks
title_short Epidemiological surveillance of Crimean-Congo haemorrhagic fever virus in the Iberian lynx (Lynx pardinus), 2010–2022
title_full Epidemiological surveillance of Crimean-Congo haemorrhagic fever virus in the Iberian lynx (Lynx pardinus), 2010–2022
title_fullStr Epidemiological surveillance of Crimean-Congo haemorrhagic fever virus in the Iberian lynx (Lynx pardinus), 2010–2022
title_full_unstemmed Epidemiological surveillance of Crimean-Congo haemorrhagic fever virus in the Iberian lynx (Lynx pardinus), 2010–2022
title_sort Epidemiological surveillance of Crimean-Congo haemorrhagic fever virus in the Iberian lynx (Lynx pardinus), 2010–2022
dc.creator.none.fl_str_mv Sánchez-Sánchez, Marta
Caballero-Gómez, Javier
Contreras, Marinela
Moraga‑Fernández, Alberto
Muñoz-Hernández, Clara
Fernández-Verón, Isabel
Fischer, Kerstin
Bost, Caroline
Castro-Scholten, Sabrina
Baz-Flores, Sara
Rey, Teresa del
Nájera, Fernando
Montoya-Oliver, Ignacio
Salcedo, Javier
Fernández de Mera, Isabel G.
García-Bocanegra, Ignacio
author Sánchez-Sánchez, Marta
author_facet Sánchez-Sánchez, Marta
Caballero-Gómez, Javier
Contreras, Marinela
Moraga‑Fernández, Alberto
Muñoz-Hernández, Clara
Fernández-Verón, Isabel
Fischer, Kerstin
Bost, Caroline
Castro-Scholten, Sabrina
Baz-Flores, Sara
Rey, Teresa del
Nájera, Fernando
Montoya-Oliver, Ignacio
Salcedo, Javier
Fernández de Mera, Isabel G.
García-Bocanegra, Ignacio
author_role author
author2 Caballero-Gómez, Javier
Contreras, Marinela
Moraga‑Fernández, Alberto
Muñoz-Hernández, Clara
Fernández-Verón, Isabel
Fischer, Kerstin
Bost, Caroline
Castro-Scholten, Sabrina
Baz-Flores, Sara
Rey, Teresa del
Nájera, Fernando
Montoya-Oliver, Ignacio
Salcedo, Javier
Fernández de Mera, Isabel G.
García-Bocanegra, Ignacio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
European Commission
Junta de Comunidades de Castilla-La Mancha
Universidad de Castilla La Mancha
Ministerio de Ciencia e Innovación (España)
Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Consejo Superior de Investigaciones Científicas (España)
CSIC - Plataforma Temática Interdisciplinar del CSIC Salud Global (PTI Salud Global)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv CCHFV
Iberian lynx
Epidemiology
Zoonosis
Ticks
topic CCHFV
Iberian lynx
Epidemiology
Zoonosis
Ticks
description Crimean-Congo haemorrhagic fever virus (CCHFV) is a zoonotic pathogen whose main vector and reservoir are Hyalomma ticks. The recent emergence of the severe disease in humans caused by this virus in southwestern Europe has alerted sanitary authorities about its public health significance. This study was aimed to assess the role of the Iberian lynx (Lynx pardinus) in the epidemiology of CCHFV in the Iberian Peninsula. Of 554 lynxes tested, anti-CCHFV antibodies were detected in 66 animals (11.9 %; 95 % confidence intervals (CI): 9.2–14.6). Age was a risk factor associated with exposure to CCHFV in free-ranging lynxes. Additionally, 63 of the 554 animals were longitudinally surveyed, nine of them seroconverted during the study period. None of the 48 blood samples and 219 feeding ticks (mostly Rhipicephalus pusillus) were positive to CCHFV RNA. The results suggest an endemic, and widespread circulation of CCHFV, particularly in the free-ranging populations, confirming the susceptibility of the Iberian lynx to CCHFV, even though they may only play a limited role in the enzootic cycle of this virus.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/407804
url http://hdl.handle.net/10261/407804
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PTA2022-022349-I
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.1016/j.vetmic.2025.110722
https://doi.org/10.1016/j.vetmic.2025.110722
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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