Epidemiological and clinical characteristics of Streptococcus tigurinus endocarditis

Background: Streptococcus tigurinus was recently described as a new streptococcal species within the viridans group streptococci (VGS). The objectives of the present work were to analyse the clinical and microbiological characteristics of S. tigurinus isolated from patients with bacteraemias, to det...

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Autores: Ercibengoa, María, Goenaga, Miguel Ángel, Ardanuy, Carmen, Grau, Immaculada, García-de-la-Maria, Cristina, Almela, Manuel, Miró, José María, Navas, Enrique, Fariñas Álvarez, María del Carmen, Ruiz de Alegría, Carlos, Torre, Javier de la, Fernández, Fernando, Marín, Mercedes, Muñoz, Patricia, Orden, Beatriz, Oteo, José Antonio, García-Álvarez, Lara, Alarcón González, Arístides de, Lepe Jiménez, José Antonio, Marimón, Jose María
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/18964
Acceso en línea:http://hdl.handle.net/10902/18964
Access Level:acceso abierto
Palabra clave:Streptococcus Viridans
Infective endocarditis
Multicentre studies
Epidemiologic surveillance
Antibiotic
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spelling Epidemiological and clinical characteristics of Streptococcus tigurinus endocarditisErcibengoa, MaríaGoenaga, Miguel ÁngelArdanuy, CarmenGrau, ImmaculadaGarcía-de-la-Maria, CristinaAlmela, ManuelMiró, José MaríaNavas, EnriqueFariñas Álvarez, María del CarmenRuiz de Alegría, CarlosTorre, Javier de laFernández, FernandoMarín, MercedesMuñoz, PatriciaOrden, BeatrizOteo, José AntonioGarcía-Álvarez, LaraAlarcón González, Arístides deLepe Jiménez, José AntonioMarimón, Jose MaríaStreptococcus ViridansInfective endocarditisMulticentre studiesEpidemiologic surveillanceAntibioticBackground: Streptococcus tigurinus was recently described as a new streptococcal species within the viridans group streptococci (VGS). The objectives of the present work were to analyse the clinical and microbiological characteristics of S. tigurinus isolated from patients with bacteraemias, to determine the prevalence of S. tigurinus among VGS endocarditis in Spain, and to compare the clinical characteristics and outcomes of endocarditis caused by S. tigurinus and other VGS. Methods: Retrospective nationwide study, performed between 2008 and 2016 in 9 Spanish hospitals from 7 different provinces comprising 237 cases of infective endocarditis. Streptococcal isolates were identified by sequencing fragments of their 16S rRNA, sodA and groEL genes. Clinical data of patients with streptococcal endocarditis were prospectively collected according to a pre-established protocol. Results: Patients with endocarditis represented 7/9 (77.8%) and 26/86 (30.2%) of the bacteraemias caused by S. tigurinus and other VGS, respectively (p < 0.001), in two of the hospital participants. Among patients with streptococcal endocarditis, 12 different Streptococcus species were recognized being S. oralis, S. tigurinus and S. mitis the three more common. No relevant statistical differences were observed in the clinical characteristics and outcomes of endocarditis caused by the different VGS species. Conclusions: In this multicenter study performed in Spain, S. tigurinus showed a higher predilection for the endocardial endothelium as compared to other VGS. However, clinical characteristics and outcomes of endocarditis caused by S. tigurinus did not significantly differ from endocarditis caused by other oral streptococci.JMM received a personal 80:20 research grant from the Institut d’InvestigacionsBiomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain during 2017–19. Nofunding entity played any role in the design of the study and data collection,analysis, and interpretation of data and in writing the manuscript.BioMed CentralUniversidad de Cantabria20192019-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttp://hdl.handle.net/10902/18964BMC Infect Dis 19, 291 (2019).reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/189642026-06-02T12:39:31Z
dc.title.none.fl_str_mv Epidemiological and clinical characteristics of Streptococcus tigurinus endocarditis
title Epidemiological and clinical characteristics of Streptococcus tigurinus endocarditis
spellingShingle Epidemiological and clinical characteristics of Streptococcus tigurinus endocarditis
Ercibengoa, María
Streptococcus Viridans
Infective endocarditis
Multicentre studies
Epidemiologic surveillance
Antibiotic
title_short Epidemiological and clinical characteristics of Streptococcus tigurinus endocarditis
title_full Epidemiological and clinical characteristics of Streptococcus tigurinus endocarditis
title_fullStr Epidemiological and clinical characteristics of Streptococcus tigurinus endocarditis
title_full_unstemmed Epidemiological and clinical characteristics of Streptococcus tigurinus endocarditis
title_sort Epidemiological and clinical characteristics of Streptococcus tigurinus endocarditis
dc.creator.none.fl_str_mv Ercibengoa, María
Goenaga, Miguel Ángel
Ardanuy, Carmen
Grau, Immaculada
García-de-la-Maria, Cristina
Almela, Manuel
Miró, José María
Navas, Enrique
Fariñas Álvarez, María del Carmen
Ruiz de Alegría, Carlos
Torre, Javier de la
Fernández, Fernando
Marín, Mercedes
Muñoz, Patricia
Orden, Beatriz
Oteo, José Antonio
García-Álvarez, Lara
Alarcón González, Arístides de
Lepe Jiménez, José Antonio
Marimón, Jose María
author Ercibengoa, María
author_facet Ercibengoa, María
Goenaga, Miguel Ángel
Ardanuy, Carmen
Grau, Immaculada
García-de-la-Maria, Cristina
Almela, Manuel
Miró, José María
Navas, Enrique
Fariñas Álvarez, María del Carmen
Ruiz de Alegría, Carlos
Torre, Javier de la
Fernández, Fernando
Marín, Mercedes
Muñoz, Patricia
Orden, Beatriz
Oteo, José Antonio
García-Álvarez, Lara
Alarcón González, Arístides de
Lepe Jiménez, José Antonio
Marimón, Jose María
author_role author
author2 Goenaga, Miguel Ángel
Ardanuy, Carmen
Grau, Immaculada
García-de-la-Maria, Cristina
Almela, Manuel
Miró, José María
Navas, Enrique
Fariñas Álvarez, María del Carmen
Ruiz de Alegría, Carlos
Torre, Javier de la
Fernández, Fernando
Marín, Mercedes
Muñoz, Patricia
Orden, Beatriz
Oteo, José Antonio
García-Álvarez, Lara
Alarcón González, Arístides de
Lepe Jiménez, José Antonio
Marimón, Jose María
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv Streptococcus Viridans
Infective endocarditis
Multicentre studies
Epidemiologic surveillance
Antibiotic
topic Streptococcus Viridans
Infective endocarditis
Multicentre studies
Epidemiologic surveillance
Antibiotic
description Background: Streptococcus tigurinus was recently described as a new streptococcal species within the viridans group streptococci (VGS). The objectives of the present work were to analyse the clinical and microbiological characteristics of S. tigurinus isolated from patients with bacteraemias, to determine the prevalence of S. tigurinus among VGS endocarditis in Spain, and to compare the clinical characteristics and outcomes of endocarditis caused by S. tigurinus and other VGS. Methods: Retrospective nationwide study, performed between 2008 and 2016 in 9 Spanish hospitals from 7 different provinces comprising 237 cases of infective endocarditis. Streptococcal isolates were identified by sequencing fragments of their 16S rRNA, sodA and groEL genes. Clinical data of patients with streptococcal endocarditis were prospectively collected according to a pre-established protocol. Results: Patients with endocarditis represented 7/9 (77.8%) and 26/86 (30.2%) of the bacteraemias caused by S. tigurinus and other VGS, respectively (p < 0.001), in two of the hospital participants. Among patients with streptococcal endocarditis, 12 different Streptococcus species were recognized being S. oralis, S. tigurinus and S. mitis the three more common. No relevant statistical differences were observed in the clinical characteristics and outcomes of endocarditis caused by the different VGS species. Conclusions: In this multicenter study performed in Spain, S. tigurinus showed a higher predilection for the endocardial endothelium as compared to other VGS. However, clinical characteristics and outcomes of endocarditis caused by S. tigurinus did not significantly differ from endocarditis caused by other oral streptococci.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10902/18964
url http://hdl.handle.net/10902/18964
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv BMC Infect Dis 19, 291 (2019).
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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